Transcription factor Brachyury,a protein containing 435 amino acids,has been widely investigated and reported in notochord differentiation and nucleus pulposus development.The crucial functions and underlying mechanis...Transcription factor Brachyury,a protein containing 435 amino acids,has been widely investigated and reported in notochord differentiation and nucleus pulposus development.The crucial functions and underlying mechanisms by Brachyury are discussed in this paper,which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration.展开更多
With the rapid development of aerospace,the Internet of Things,wearable devices,and portable instruments,the application scenarios for sensors are expanding and requiring higher performance in terms of conversion effi...With the rapid development of aerospace,the Internet of Things,wearable devices,and portable instruments,the application scenarios for sensors are expanding and requiring higher performance in terms of conversion efficiency,flexibility,and stability.However,most sensors are powered by an external power source,which hinders the construction of flexible sensors due to their rigid nature.展开更多
Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be...Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be inappropriate.Therefore,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 weeks.The effects of dietary iron supplementation with different sources and levels on semen quality in boars were investigated.Results 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(P<0.05),and higher serum superoxide dismutase levels and lower MDA levels in the 115 mg/kg MHA-Fe group(P<0.05).3)Boars in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups had lower serum hepcidin(P<0.01),ferritin(P<0.05),and transferrin receptor(P<0.01)concentrations,and boars in the 115 mg/kg MHA-Fe group had higher seminal plasma Fe concentrations compared with the control group.4)Boars in the 80 mg/kg and 115 mg/kg MHA-Fe groups had lower abnormal sperm rate and in situ oscillating sperm ratio compared to the control group at weeks 12 and/or 16 of the trial.However,the effect of Gly-Fe on improving semen quality in boars was not evident.5)Serum IL-6 level was positively correlated with hepcidin concentration(P<0.05),which in turn was significantly positively correlated with abnormal sperm rate(P<0.05).Furthermore,significant correlations were also found between indicators of iron status and oxidative stress and semen quality parameters.Conclusions Dietary supplementation with 80 mg/kg or 115 mg/kg MHA-Fe did not induce iron deficiency,but rather reduced serum inflammatory levels and hepcidin concentration,alleviated oxidative stress,increased body iron utilization,and improved semen quality in adult boars.展开更多
Accurate plantar pressure mapping systems with low dependence on the external power supply are highly desired for preventative healthcare and medical diagnosis.Herein,we propose a self-powered smart insole system that...Accurate plantar pressure mapping systems with low dependence on the external power supply are highly desired for preventative healthcare and medical diagnosis.Herein,we propose a self-powered smart insole system that can perform both static and dynamic plantar pressure mapping with high accuracy.The smart insole system integrates an insole-shaped sensing unit,a multi-channel data acquisition board,and a data storage module.The smart insole consists of a 44-pixel sensor array based on triboelectric nanogenerators(TENGs)to transduce pressure to the electrical signal.By optimizing the sensor architecture and the system's robustness,the smart insole achieves high sensitivity,good error-tolerance capability,excellent durability,and short response–recovery time.Various gait and mobility patterns,such as standing,introversion/extraversion,throwing,and surpassing obstacles,can be distin-guished by analyzing the acquired electrical signals.This work paves the way for self-powered wearable devices for gait monitoring,which might enable a new modality of medical diagnosis.展开更多
It is increasingly common to find graphs in which edges are of different types, indicating a variety of relation- ships. For such graphs we propose a class of reachability queries and a class of graph patterns, in whi...It is increasingly common to find graphs in which edges are of different types, indicating a variety of relation- ships. For such graphs we propose a class of reachability queries and a class of graph patterns, in which an edge is specified with a regular expression of a certain form, ex- pressing the connectivity of a data graph via edges of var- ious types. In addition, we define graph pattern matching based on a revised notion of graph simulation. On graphs in emerging applications such as social networks, we show that these queries are capable of finding more sensible informa- tion than their traditional counterparts. Better still, their in- creased expressive power does not come with extra complex- ity. Indeed, （1） we investigate their containment and mini- mization problems, and show that these fundamental prob- lems are in quadratic time for reachability queries and are in cubic time for pattern queries. （2） We develop an algorithm for answering reachability queries, in quadratic time as for their traditional counterpart. （3） We provide two cubic-time algorithms for evaluating graph pattern queries, as opposed to the NP-completeness of graph pattern matching via subgraph isomorphism. （4） The effectiveness and efficiency of these al- gorithms are experimentally verified using real-life data and synthetic data.展开更多
Supercritical water fuidized bed reactor(SCWFBR)is a novel concept for the gasification of coal and biomass to produce hydrogen.In this work,to enhance the mixing in the axial direction,an inclined distributor is intr...Supercritical water fuidized bed reactor(SCWFBR)is a novel concept for the gasification of coal and biomass to produce hydrogen.In this work,to enhance the mixing in the axial direction,an inclined distributor is introduced to optimize the flow dynamics in SCWFBR with partitioned fluid supply.Through numerical simulations based on the two fluid model(TFM),the effects of the inclined distributor structure and operating parameters on the solid distribution and the residence time are evaluated with the optimal values determined.Numerical results show that,area ratio-2:1,scw velocity ratio-3:1,flow ratio=3.36:1 and inclination angle=20°are the optimal design in this paper.A predictive correlation of the minimum fluidization velocity for the improved SCWFBR is also proposed based on the numerical data.The average error between the correlation and numerical simulation results is approximately 1.4%which strongly demonstrates its capability.Finally,based on the optimal design,the labscale reactoris further scaled up and the studies about twoscale-uprules are carried out.Only the cold flow is simulated in this study without considering chemical reaction which would be involved in future work.展开更多
Polycyclic aromatic hydrocarbons(PAHs)are persistent and widespread in the aquatic environment,causing potential hazards for human health.In this study,a superwetting and robust PES-PAA-ZrO_(2)nanofiltration membrane ...Polycyclic aromatic hydrocarbons(PAHs)are persistent and widespread in the aquatic environment,causing potential hazards for human health.In this study,a superwetting and robust PES-PAA-ZrO_(2)nanofiltration membrane was proposed through surface modification for PAH removal with high efficiency.A ZrO_(2)coating was formed on polyethersulfone(PES)membrane surface through chemical bonding,thus the PES-PAA-ZrO_(2)membrane exhibited super-hydrophilicity,under-water oleophobicity,and excellent stability.In comparison with the original PES membrane,the water contact angle of the modified membrane was significantly decreased from about 50°to less than 10°,and quickly dropped to 0°within 1s.This provided a much lower energy barrier for water permeation due to its super-high water affinity.The wastewater treatment efficiency was increased by about 4 times after modification with more than 90%of PAH rejection rate.The excellent robustness of PES-PAA-ZrO_(2)membrane was verified under various conditions,which gave the membrane practical potential for long-term operation.展开更多
基金This work was supported by the Gusu Health Talent Project of Suzhou(Grant No.GSWS2020056)“333”Talent Project of Jiangsu Province(Grant No.BRA2017057).
文摘Transcription factor Brachyury,a protein containing 435 amino acids,has been widely investigated and reported in notochord differentiation and nucleus pulposus development.The crucial functions and underlying mechanisms by Brachyury are discussed in this paper,which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration.
基金supported by the National Natural Science Foundation of China(51973119 and 52150009)Shenzhen Science and Technology Program,(ZDSYS20220606100406016)Guangdong Provincial Key Laboratory of Durability for Marine Civil Engineering(SZU)(2020B1212060074)。
文摘With the rapid development of aerospace,the Internet of Things,wearable devices,and portable instruments,the application scenarios for sensors are expanding and requiring higher performance in terms of conversion efficiency,flexibility,and stability.However,most sensors are powered by an external power source,which hinders the construction of flexible sensors due to their rigid nature.
基金China Agriculture Research System(CARS-36)Major Project of Technical Innovation in Hubei Province(No.2022BBA0056)+1 种基金Dekon-Huazhong Agricultural University Project Co-operation AgreementSchool-Enterprise Cooperation Project-Micronutrient Nutrition and Mechanism of Breeding Pigs。
文摘Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be inappropriate.Therefore,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 weeks.The effects of dietary iron supplementation with different sources and levels on semen quality in boars were investigated.Results 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(P<0.05),and higher serum superoxide dismutase levels and lower MDA levels in the 115 mg/kg MHA-Fe group(P<0.05).3)Boars in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups had lower serum hepcidin(P<0.01),ferritin(P<0.05),and transferrin receptor(P<0.01)concentrations,and boars in the 115 mg/kg MHA-Fe group had higher seminal plasma Fe concentrations compared with the control group.4)Boars in the 80 mg/kg and 115 mg/kg MHA-Fe groups had lower abnormal sperm rate and in situ oscillating sperm ratio compared to the control group at weeks 12 and/or 16 of the trial.However,the effect of Gly-Fe on improving semen quality in boars was not evident.5)Serum IL-6 level was positively correlated with hepcidin concentration(P<0.05),which in turn was significantly positively correlated with abnormal sperm rate(P<0.05).Furthermore,significant correlations were also found between indicators of iron status and oxidative stress and semen quality parameters.Conclusions Dietary supplementation with 80 mg/kg or 115 mg/kg MHA-Fe did not induce iron deficiency,but rather reduced serum inflammatory levels and hepcidin concentration,alleviated oxidative stress,increased body iron utilization,and improved semen quality in adult boars.
基金Startup Funding from Local Government,Grant/Award Number:827/000544National Natural Science Foundation of China,Grant/Award Number:51973119+4 种基金Program of the China Postdoctoral Science Foundation,Grant/Award Number:2022M712160Program of the National Natural Science Foundation of China,Grant/Award Number:52150009Open Project of Key Lab of Special Functional Materials of Ministry of Education,Henan University,Grant/Award Number:KFKT-2022-10High-Level University Construction Fund,Grant/Award Number:860-000002081205Natural Science Foundation of Guangdong Province,Grant/Award Number:2019A1515011566。
文摘Accurate plantar pressure mapping systems with low dependence on the external power supply are highly desired for preventative healthcare and medical diagnosis.Herein,we propose a self-powered smart insole system that can perform both static and dynamic plantar pressure mapping with high accuracy.The smart insole system integrates an insole-shaped sensing unit,a multi-channel data acquisition board,and a data storage module.The smart insole consists of a 44-pixel sensor array based on triboelectric nanogenerators(TENGs)to transduce pressure to the electrical signal.By optimizing the sensor architecture and the system's robustness,the smart insole achieves high sensitivity,good error-tolerance capability,excellent durability,and short response–recovery time.Various gait and mobility patterns,such as standing,introversion/extraversion,throwing,and surpassing obstacles,can be distin-guished by analyzing the acquired electrical signals.This work paves the way for self-powered wearable devices for gait monitoring,which might enable a new modality of medical diagnosis.
文摘It is increasingly common to find graphs in which edges are of different types, indicating a variety of relation- ships. For such graphs we propose a class of reachability queries and a class of graph patterns, in which an edge is specified with a regular expression of a certain form, ex- pressing the connectivity of a data graph via edges of var- ious types. In addition, we define graph pattern matching based on a revised notion of graph simulation. On graphs in emerging applications such as social networks, we show that these queries are capable of finding more sensible informa- tion than their traditional counterparts. Better still, their in- creased expressive power does not come with extra complex- ity. Indeed, （1） we investigate their containment and mini- mization problems, and show that these fundamental prob- lems are in quadratic time for reachability queries and are in cubic time for pattern queries. （2） We develop an algorithm for answering reachability queries, in quadratic time as for their traditional counterpart. （3） We provide two cubic-time algorithms for evaluating graph pattern queries, as opposed to the NP-completeness of graph pattern matching via subgraph isomorphism. （4） The effectiveness and efficiency of these al- gorithms are experimentally verified using real-life data and synthetic data.
基金the National Natural Science Foundation of China(grant No.12072071)the Natural Science Foundation of Liaoning Province(grant No.2019-MS-125)for the financial support on this research.
文摘Supercritical water fuidized bed reactor(SCWFBR)is a novel concept for the gasification of coal and biomass to produce hydrogen.In this work,to enhance the mixing in the axial direction,an inclined distributor is introduced to optimize the flow dynamics in SCWFBR with partitioned fluid supply.Through numerical simulations based on the two fluid model(TFM),the effects of the inclined distributor structure and operating parameters on the solid distribution and the residence time are evaluated with the optimal values determined.Numerical results show that,area ratio-2:1,scw velocity ratio-3:1,flow ratio=3.36:1 and inclination angle=20°are the optimal design in this paper.A predictive correlation of the minimum fluidization velocity for the improved SCWFBR is also proposed based on the numerical data.The average error between the correlation and numerical simulation results is approximately 1.4%which strongly demonstrates its capability.Finally,based on the optimal design,the labscale reactoris further scaled up and the studies about twoscale-uprules are carried out.Only the cold flow is simulated in this study without considering chemical reaction which would be involved in future work.
基金supported by the National Key Research and Development Plan(2016YFA0601502)the Canada Research Chairs(CRC)Program+3 种基金the Canada Foundation for Innovation(CFI)the Natural Science and Engineering Research Council(NSERC)of CanadaWestern Canada Clean Energy Initiative(No.000015269)Petroleum Technology Research Centre
文摘Polycyclic aromatic hydrocarbons(PAHs)are persistent and widespread in the aquatic environment,causing potential hazards for human health.In this study,a superwetting and robust PES-PAA-ZrO_(2)nanofiltration membrane was proposed through surface modification for PAH removal with high efficiency.A ZrO_(2)coating was formed on polyethersulfone(PES)membrane surface through chemical bonding,thus the PES-PAA-ZrO_(2)membrane exhibited super-hydrophilicity,under-water oleophobicity,and excellent stability.In comparison with the original PES membrane,the water contact angle of the modified membrane was significantly decreased from about 50°to less than 10°,and quickly dropped to 0°within 1s.This provided a much lower energy barrier for water permeation due to its super-high water affinity.The wastewater treatment efficiency was increased by about 4 times after modification with more than 90%of PAH rejection rate.The excellent robustness of PES-PAA-ZrO_(2)membrane was verified under various conditions,which gave the membrane practical potential for long-term operation.
