Most studies support the viewpoint that the vomeronasal organ has a profound effect on conspecific odor recognition,scent marking and mating behavior in the golden hamster(Mesocricetus auratus).However,the role ...Most studies support the viewpoint that the vomeronasal organ has a profound effect on conspecific odor recognition,scent marking and mating behavior in the golden hamster(Mesocricetus auratus).However,the role of the vomeronasal organ in social odor recognition,social interaction and fitness is not well understood.Therefore,we conducted a series of behavioral and physiological tests to examine the referred points in golden hamster.We found that male hamsters with vomeronasal organ lesion showed no preference between a predator odor(the anal gland secretion of the Siberian weasels(Mustela sibirica)and putative female pheromone components(myristic acid and palmitic acid),but were still able to discriminate between these 2 kinds of odors.In behavioral tests of anxiety,we found that vomeronasal organ removal causes female hamsters to spend much less time in center grids and to cross fewer center grids and males to make fewer crossings between light and dark boxes than sham-operated controls.This indicates that a chronic vomeronasal organ lesion induced anxious responses in females.In aggressive behavioral tests,we found that a chronic vomeronasal organ lesion decreased agonistic behavior in female hamsters but not in males.The pup growth and litter size show no differences between the 2 groups.All together,our data suggested that vomeronasal organ ablation disrupted the olfactory recognition of social chemosignals in males,and induced anxiety-like and aggressive behavior changes in females.However,a vomeronasal organ lesion did not affect the reproductive capacity and fitness of hamsters.Our studies may have important implications concerning the role of the vomeronasal organ in golden hamsters and also in rodents.展开更多
Congenital heart disease(CHD)is the commonest birth defect,affecting approximately 9.4/1000 live births.^(1)Atrial Septal Defect(ASD)is one of the commonest CHD clinical phenotypes,which frequently requires treatment ...Congenital heart disease(CHD)is the commonest birth defect,affecting approximately 9.4/1000 live births.^(1)Atrial Septal Defect(ASD)is one of the commonest CHD clinical phenotypes,which frequently requires treatment either in childhood or adulthood,and can lead to severe complications such as right heart failure and cardiac arrhythmia.Previous genome-wide association studies(GWAS)have identified a region of chromosome 4p16(Ch4p16)associated with the risk of ASD.展开更多
基金This work was supported mainly by the grants from National Basic Research Program of China(973 Program,No.2010CB833900)Chinese Academy of Sciences(KSCX2-EW-N-5)China National Science Foundation(No.31272322 to J.Zhang and No.31172097 to D.Liu).
文摘Most studies support the viewpoint that the vomeronasal organ has a profound effect on conspecific odor recognition,scent marking and mating behavior in the golden hamster(Mesocricetus auratus).However,the role of the vomeronasal organ in social odor recognition,social interaction and fitness is not well understood.Therefore,we conducted a series of behavioral and physiological tests to examine the referred points in golden hamster.We found that male hamsters with vomeronasal organ lesion showed no preference between a predator odor(the anal gland secretion of the Siberian weasels(Mustela sibirica)and putative female pheromone components(myristic acid and palmitic acid),but were still able to discriminate between these 2 kinds of odors.In behavioral tests of anxiety,we found that vomeronasal organ removal causes female hamsters to spend much less time in center grids and to cross fewer center grids and males to make fewer crossings between light and dark boxes than sham-operated controls.This indicates that a chronic vomeronasal organ lesion induced anxious responses in females.In aggressive behavioral tests,we found that a chronic vomeronasal organ lesion decreased agonistic behavior in female hamsters but not in males.The pup growth and litter size show no differences between the 2 groups.All together,our data suggested that vomeronasal organ ablation disrupted the olfactory recognition of social chemosignals in males,and induced anxiety-like and aggressive behavior changes in females.However,a vomeronasal organ lesion did not affect the reproductive capacity and fitness of hamsters.Our studies may have important implications concerning the role of the vomeronasal organ in golden hamsters and also in rodents.
基金supported by The University of Manchester-Peking University Health Science Centre Alliance,the China Scholarships Council,and British Heart Foundation Programme Grant RG/15/12/31616.
文摘Congenital heart disease(CHD)is the commonest birth defect,affecting approximately 9.4/1000 live births.^(1)Atrial Septal Defect(ASD)is one of the commonest CHD clinical phenotypes,which frequently requires treatment either in childhood or adulthood,and can lead to severe complications such as right heart failure and cardiac arrhythmia.Previous genome-wide association studies(GWAS)have identified a region of chromosome 4p16(Ch4p16)associated with the risk of ASD.
