The ultra-precision field is popular for its micro-nanometer positioning accuracy and large working stroke.Piezoelectric actuators based on the stick-slip operational principle exhibit superior performance characteris...The ultra-precision field is popular for its micro-nanometer positioning accuracy and large working stroke.Piezoelectric actuators based on the stick-slip operational principle exhibit superior performance characteristics,making them stand out with unique advantages in this field.This paper provides a comprehensive review of the developments in stick-slip piezoelectric actuators over recent years.Starting with a detailed explanation of their operating principles,the article proceeds with a brief introduction to the more commonly used driving waveforms and their applications.Subsequently,various design and optimization technologies for existing com-pliant mechanisms are presented.Furthermore,stick-slip piezoelectric actuators are categorized based on different motion forms,including linear,rotary,and multi-degree of freedom types.Each category is thoroughly examined in terms of structural design and performance features.Following this,the discussion shifts toward controller method research and friction modeling analysis,featuring a particular emphasis on the advancements related to displacement back-lash suppression studies.This systematic summary aims to provide a reference for researchers within related fields,thereby facilitating the further development and application of stick-slip piezoelectric actuators.展开更多
Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disea...Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.However,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment.展开更多
Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial role...Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial roles.IL2RG is essential for the development,differentiation,and functioning of T,B,and NK cells,while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination during the maturation of lymphocytes.Animal models carrying mutations in these genes exhibit notable deficiencies in their immune systems.展开更多
基金supported by the National Natural Science Foundation of China [No.52075108,52105177]the Natural Science Foundation of Guangdong Province,China [No.2022A1515011875]the Young innovative talents project of general colleges and universities in Guangdong Province,China [No.2021KQNCX067].
文摘The ultra-precision field is popular for its micro-nanometer positioning accuracy and large working stroke.Piezoelectric actuators based on the stick-slip operational principle exhibit superior performance characteristics,making them stand out with unique advantages in this field.This paper provides a comprehensive review of the developments in stick-slip piezoelectric actuators over recent years.Starting with a detailed explanation of their operating principles,the article proceeds with a brief introduction to the more commonly used driving waveforms and their applications.Subsequently,various design and optimization technologies for existing com-pliant mechanisms are presented.Furthermore,stick-slip piezoelectric actuators are categorized based on different motion forms,including linear,rotary,and multi-degree of freedom types.Each category is thoroughly examined in terms of structural design and performance features.Following this,the discussion shifts toward controller method research and friction modeling analysis,featuring a particular emphasis on the advancements related to displacement back-lash suppression studies.This systematic summary aims to provide a reference for researchers within related fields,thereby facilitating the further development and application of stick-slip piezoelectric actuators.
基金This work was supported by the Guangzhou Key Research Program on Brain Science(202007030008,202007030003)The National Natural Science Foundation of China(32170981,81830032,31872779,81922026,82071421,82171244)+2 种基金National Key Research and Development Program of China(2021YFA0805300,2021YFA0805200)Department of Science and Technology of Guangdong Province(2021ZT09Y007,2020B121201006)Key Field Research and Development Program of Guangdong province(2018B030337001).
文摘Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.However,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment.
基金This work was supported by the National Key Research and Development Program of China(2021YFA0805300,2021YFA0805204)the National Natural Science Foundation of China(82171244,81922026,32170981)Guangzhou Key Research Program on Brain Science(202007030008).
文摘Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial roles.IL2RG is essential for the development,differentiation,and functioning of T,B,and NK cells,while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination during the maturation of lymphocytes.Animal models carrying mutations in these genes exhibit notable deficiencies in their immune systems.
