Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se- quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus （129 diab...Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se- quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus （129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy pa- tients） and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.展开更多
Increasing global population and decreasing arable land pose tremendous pressures to agricultural production.The application of conventional chemical fertilizers improves agricultural production,but causes serious env...Increasing global population and decreasing arable land pose tremendous pressures to agricultural production.The application of conventional chemical fertilizers improves agricultural production,but causes serious environmental problems and significant economic burdens.Biochar gains increasing interest as a soil amendment.Recently,more and more attentions have been paid to biochar-based slowrelease of fertilizers(SRFs)due to the unique properties of biochar.This review summarizes recent advances in the development,synthesis,application,and tentative mechanism of biochar-based SRFs.The development mainly undergoes three stages:(i)soil amendment using biochar,(ii)interactions between nutrients and biochar,and(iii)biochar-based SRFs.Various methods are proposed to improve the fertilizer efficiency of biochar,majorly including in-situ pyrolysis,co-pyrolysis,impregnation,encapsulation,and granulation.Considering the distinct features of different methods,the integrated methods are promising for fabricating effective biochar-based SRFs.The in-depth understanding of the mechanism of nutrient loading and slow release is discussed based on current knowledge.Additionally,the perspectives and challenges of the potential application of biochar-based SRFs are described.Knowledge surveyed from this review indicates that applying biochar-based SRFs is a viable way of promoting sustainable agriculture.展开更多
基金financially sponsored by the Natural Science Foundation of Beijing,No.7102161
文摘Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se- quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus （129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy pa- tients） and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.
基金the National Key Research and Development Project(2020YFC1908802),Chinathe National Natural Science Foundation of China(U1704252 and 51804276),Chinathe Young Elite Scientist Sponsorship Program by CAST(2019QNRC001),China.
文摘Increasing global population and decreasing arable land pose tremendous pressures to agricultural production.The application of conventional chemical fertilizers improves agricultural production,but causes serious environmental problems and significant economic burdens.Biochar gains increasing interest as a soil amendment.Recently,more and more attentions have been paid to biochar-based slowrelease of fertilizers(SRFs)due to the unique properties of biochar.This review summarizes recent advances in the development,synthesis,application,and tentative mechanism of biochar-based SRFs.The development mainly undergoes three stages:(i)soil amendment using biochar,(ii)interactions between nutrients and biochar,and(iii)biochar-based SRFs.Various methods are proposed to improve the fertilizer efficiency of biochar,majorly including in-situ pyrolysis,co-pyrolysis,impregnation,encapsulation,and granulation.Considering the distinct features of different methods,the integrated methods are promising for fabricating effective biochar-based SRFs.The in-depth understanding of the mechanism of nutrient loading and slow release is discussed based on current knowledge.Additionally,the perspectives and challenges of the potential application of biochar-based SRFs are described.Knowledge surveyed from this review indicates that applying biochar-based SRFs is a viable way of promoting sustainable agriculture.
