New strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with several dominant mutations in the spike protein have been identified recently,and crucial issues associated with the possible reinfection ...New strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with several dominant mutations in the spike protein have been identified recently,and crucial issues associated with the possible reinfection of recovered patients and the efficiencies of vaccines designed based on epidemic strains in early 2020.展开更多
To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to co...To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2].展开更多
基金supported by the National Special Research Program of China for Important Infectious Diseases(2018ZX10302103 and 2017ZX10202102)the Special 2019-nCoV Program of Natural Science Foundation of China(NSFC)(82041002)+4 种基金the Special 2019-nCoV Project of National Key Research and Development Program of China(2020YFC0841400)the Special 2019-nCoV Project of Research and Development Program of G uangdong(2020B111123001)the Important Key Program of NSFC(81730060)the Joint-innovation Program in Healthcare for Special Scientific Research Projects of Guangzhou(201803040002)to H.ZThis work was also supported by the National Postdoctoral Program for Innovative Talents and the General Program of China Postdoctoral Science Foundation(BX20190398 and 2019M663215)to X.M.
文摘New strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with several dominant mutations in the spike protein have been identified recently,and crucial issues associated with the possible reinfection of recovered patients and the efficiencies of vaccines designed based on epidemic strains in early 2020.
基金This work was supported by the National Special Research Program of China for Important Infectious Diseases(2017ZX10202102 and 2018ZX10302103)the Special 2019-nCoV Project of the National Key Research and Development Program of China(2020YFC0841400)+4 种基金the First Panel of 2021 Emergency Key Program of Guangzhou Laboratory(EKPG21-24)the Special 2019-nCoV Program of the Natural Science Foundation of China(NSFC)(82041002)the Special Research and Development Program of Guangzhou(202008070010)the Important Key Program of NSFC(81730060)the Joint-Innovation Program in Healthcare for Special Scientific Research Projects of Guangzhou(201803040002)to H.Z.
文摘To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2].
