The human microbiota,a diverse community of microorganisms living on or within their hosts,play an irreplaceable role in maintaining human health.Dysbiosis of the microbiota is associated with the pathogenesis of dive...The human microbiota,a diverse community of microorganisms living on or within their hosts,play an irreplaceable role in maintaining human health.Dysbiosis of the microbiota is associated with the pathogenesis of diverse human dis-eases.In recent years,growing evidence has been presented to support the substantial effect of human microbiota on the progression of infectious diseases.In this review,we describe the functional role of human microbiota in infec-tious diseases by highlighting their Janus-faced effects in the regulation of acute and chronic infections as well as their related co-morbidities.Thereafter,we review the latest advances elucidating the mechanisms underlying tri-directional interactions between the microbiota,hosts,and invading pathogens,with a further discussion on external environ-mental factors that shape this interconnected regulatory network.A better understanding of the regulatory functions and mechanisms of human microbiota in infectious diseases will facilitate the development of new diagnostic,preven-tive,and therapeutic approaches for infectious diseases.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2302900 to C.H.L.,2021YFA1300200 to C.H.L.and L.Z.,and 2022YFC2303201 to Q.C.)the National Natural Science Foundation of China(82330069,81825014,and 31830003 to C.H.L.and 82171744 to Q.C.)the State Key Laboratory of Proteomics(SKLP-K202001 to C.H.L.and L.Z.).
文摘The human microbiota,a diverse community of microorganisms living on or within their hosts,play an irreplaceable role in maintaining human health.Dysbiosis of the microbiota is associated with the pathogenesis of diverse human dis-eases.In recent years,growing evidence has been presented to support the substantial effect of human microbiota on the progression of infectious diseases.In this review,we describe the functional role of human microbiota in infec-tious diseases by highlighting their Janus-faced effects in the regulation of acute and chronic infections as well as their related co-morbidities.Thereafter,we review the latest advances elucidating the mechanisms underlying tri-directional interactions between the microbiota,hosts,and invading pathogens,with a further discussion on external environ-mental factors that shape this interconnected regulatory network.A better understanding of the regulatory functions and mechanisms of human microbiota in infectious diseases will facilitate the development of new diagnostic,preven-tive,and therapeutic approaches for infectious diseases.
