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吡罗克酮乙醇胺盐的蛋白酶抑制作用及与硫酸锌复配的防脱发功效研究 被引量:1
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作者 Ranjit Kaur Bhogal 陈旭斌 +4 位作者 David Messenger 宫哲慧 孙佳凝 皮瑛瑛 顾佳音 《日用化学工业(中英文)》 CAS 北大核心 2023年第4期390-397,共8页
蛋白水解机制导致棒状末端发根和毛囊之间的细胞粘附分解是头发脱落的最终步骤。在休止期晚期和脱落期,蛋白酶活性的增加导致大量脱发。利用EnzChek^(TM)蛋白酶试剂盒,基于荧光方法检测了吡罗克酮乙醇胺盐在体外对蛋白酶的抑制作用;并... 蛋白水解机制导致棒状末端发根和毛囊之间的细胞粘附分解是头发脱落的最终步骤。在休止期晚期和脱落期,蛋白酶活性的增加导致大量脱发。利用EnzChek^(TM)蛋白酶试剂盒,基于荧光方法检测了吡罗克酮乙醇胺盐在体外对蛋白酶的抑制作用;并对含吡罗克酮乙醇胺盐和硫酸锌的洗发水进行了两组含受脱发困扰的男性和女性参与者的临床防脱发功效测试。结果表明,吡罗克酮乙醇胺盐可以有效抑制蛋白酶的活性,0.5%吡罗克酮乙醇胺盐在体外可使胰蛋白酶的活性减少最高达53%。硫酸锌可以增强低浓度吡罗克酮乙醇胺盐对胰蛋白酶活性的抑制作用。两组临床测试显示,使用含0.5%吡罗克酮乙醇胺盐和0.018%硫酸锌的洗发水4周,8周和12周后,头发密度较使用前均有显著性增加,12周后分别增加2.7根/cm^(2)和7.5根/cm^(2);较空白对照组,在8周和12周后均有显著性提高。由此提示了吡罗克酮乙醇胺盐对于棒状毛发的保留作用和含吡罗克酮乙醇胺盐和硫酸锌洗发水的防脱发功效。 展开更多
关键词 脱发 脱落期 毛发密度 蛋白酶 吡罗克酮乙醇胺盐 硫酸锌
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A hybrid differential evolution algorithm for a stochastic location-inventory-delivery problem with joint replenishment
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作者 Sirui Wang Lin Wang yingying pi 《Data Science and Management》 2022年第3期124-136,共13页
A practical stochastic location-inventory-delivery problem with multi-item joint replenishment is studied.Unlike the conventional location-inventory model with a continuous-review(r,Q)inventory policy,the periodic-rev... A practical stochastic location-inventory-delivery problem with multi-item joint replenishment is studied.Unlike the conventional location-inventory model with a continuous-review(r,Q)inventory policy,the periodic-review inventory policy is adopted with multi-item joint replenishment under stochastic demand,and the coordinated delivery cost is considered.The proposed model considers the integrated optimization of strategic,tactical,and operational decisions by simultaneously determining(a)the number and location of distribution centers(DCs)to be opened,(b)the assignment of retailers to DCs,(c)the frequency and cycle interval of replenishment and delivery,and(d)the safety stock level for each item.An intelligent algorithm based on particle swarm optimization(PSO)and adaptive differential evolution(ADE)is proposed to address this complex problem.Numerical experiments verified the effectiveness of the proposed two-stage PSO-ADE algorithm.A sensitivity analysis is presented to reveal interesting insights that can guide managers in making reasonable decisions. 展开更多
关键词 Location-inventory problem Joint replenishment Stochastic demand Particle swarm optimization Differential evolution
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