Herein,we report a novel heterogeneous photocatalyst for radical-mediated oxidative oxysulfonylation of alkynes toβ-keto sulfones under environmentally benign conditions.The oxygen vacancy-rich semiconductor Nb2O5(la...Herein,we report a novel heterogeneous photocatalyst for radical-mediated oxidative oxysulfonylation of alkynes toβ-keto sulfones under environmentally benign conditions.The oxygen vacancy-rich semiconductor Nb2O5(labeled as OVs-N-Nb_(2)O_(5))could efficiently catalyze a wide range of alkynes,especially for those bearing electron-deficient substituents or internal alkynes,to their correspondingβ-keto sulfones in good to high yields with good tolerance of diverse functional groups under visible-light illumination.The late-stage modification of steroidal compounds and synthesis of bioactive molecules were also achieved via this procedure,highlighting its potential for practical applications.Meanwhile,the photocatalyst OVs-N-Nb_(2)O_(5) showed outstanding catalytic stability for successive recycles without appreciable loss in activity and selectivity.The critical role of oxygen vacancies on improving reaction activity and selectivity was clearly disclosed via control experiments and theoretical calculation.展开更多
基金supportof the National Natural Science Foundation of China(Nos.22002178,22078350)the Natural Science Foundation of Shandong Province(ZR2020KB016)+1 种基金Shandong Energy Institute Fund(Grant No.SEll202138)Y.Y.alsothanks the Royal Society(UK)fora Newton Advanced Fellowship(NAF/R2/180695).
文摘Herein,we report a novel heterogeneous photocatalyst for radical-mediated oxidative oxysulfonylation of alkynes toβ-keto sulfones under environmentally benign conditions.The oxygen vacancy-rich semiconductor Nb2O5(labeled as OVs-N-Nb_(2)O_(5))could efficiently catalyze a wide range of alkynes,especially for those bearing electron-deficient substituents or internal alkynes,to their correspondingβ-keto sulfones in good to high yields with good tolerance of diverse functional groups under visible-light illumination.The late-stage modification of steroidal compounds and synthesis of bioactive molecules were also achieved via this procedure,highlighting its potential for practical applications.Meanwhile,the photocatalyst OVs-N-Nb_(2)O_(5) showed outstanding catalytic stability for successive recycles without appreciable loss in activity and selectivity.The critical role of oxygen vacancies on improving reaction activity and selectivity was clearly disclosed via control experiments and theoretical calculation.
