Prospects for Jovian seismology with the Lenghu planetary telescope

Jupiter is one of the top priorities for deep space exploration in China and other countries.The structure of Jupiter’s interior,in particular,is a crucial but still unclear scientific topic.This paper discusses current scientific understanding of Jupiter’s interior by summarizing the history of past and current exploration and data analysis.We review recent space-based and ground-based observation methods and analyze their feasibility.To gain new insight into the internal structure of Jupiter,we propose to study Jupiter’s innards by planetary seismology.Ground-based observation,namely the Jupiter Seismologic Interferometer Polarization Imager(SIPI)in Lenghu,will be developed to obtain the Doppler velocity distribution on the surface of Jupiter and identify oscillation signals.Lenghu has observation conditions that are not only exceptional in China but even in the world,capable of providing novel insight into the interior of Jupiter.This will also be the first study in China of the interior of Jupiter using asteroseismology,which has significant implications for China’s plans to explore Jupiter via spacecraft-mounted instruments.

Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment

Helicobacter pylori(H.pylori),creating a global infection rate over 50%,presents great challenges in clinical therapies due to its complex pathological microenvironment in vivo.To improve the eradication efficacy,herein we fabricated a pharmaceutical vesicle RHL/Cl-Ch-cal where cholesterol-PEG,calcitriol and first-line antibiotic clarithromycin were co-loaded in the rhamnolipid-composed outer lipid layer.RHL/Cl-Ch-cal could quickly penetrate through gastric mucus layer to reach H.pylori infection sites,and then effectively destroyed the architecture of H.pylori biofilms,killed dispersed H.pylori and inhibited the re-adhesion of residual bacteria(called biofilms eradication tetralogy).Moreover,RHL/Cl-Ch-cal activated the host immune response to H.pylori by replenishing cholesterol to repair lipid raft on the cell membrane of host epithelial cells.Finally,RHL/Cl-Ch-cal killed the intracellular H.pylori through recovering the lysosomal acidification and assisting degradation.In experiments,RHL/Cl-Ch-cal demonstrated prominent anti-H.pylori efficacy in the classical H.pylori-infected mice model.Therefore,the study provides a“comprehensive attack”strategy for anti-H.pylori therapies including biofilms eradication tetralogy,immune activation and intracellular bacteria killing.