The new view denies the existence of fundamental particles in matter, and instead states that any particle and matter is a dynamic superposition of three natural elements, motion, force, and emptiness. This paper prop...The new view denies the existence of fundamental particles in matter, and instead states that any particle and matter is a dynamic superposition of three natural elements, motion, force, and emptiness. This paper proposes a new theory of the structure of matter and the unification of the four forces. A correct understanding of the logic of material structure will enable atomic energy and nuclear physics to generate new manufacturing ideas. The dissertation expounds the natural distribution of dynamics and forces in space and the new deterministic theory of dynamic relationship. This theory solves problems such as the unity of the four forces and the dynamic laws of the material structure. In practical applications, it can provide new theoretical guidance for industrial manufacturing such as nuclear energy, fusion engineering, new energy, new materials, battery energy storage, new-generation reactors, etc., and then adopt effective means in line with the laws of natural power to make the substances needed by human beings. The supply of resources and energy is perfectly satisfied. Applying this theoretical model of material structure to all aspects of the manufacturing industry will surely open up a new era of material civilization for human beings.展开更多
Background:Abnormal expression of long non-coding RNAs(lncRNAs)has been found in almost all tumors in humans,providing numerous potential diagnostic and prognostic biomarkers,and therapeutic targets.Materials and meth...Background:Abnormal expression of long non-coding RNAs(lncRNAs)has been found in almost all tumors in humans,providing numerous potential diagnostic and prognostic biomarkers,and therapeutic targets.Materials and methods:The Cancer Genome Atlas(TCGA)database was used to screen potential LncRNAs,and 30 paired hepatocellular carcinoma(HCC)tissues were used to investigate RP11-307C12.11 expression levels by qRT-PCR and another 105 HCC tissues by in situ hybridizsation(ISH).RP11-307C12.11 overexpression and knockdown experiments were performed to investigate the effects of RP11-307C12.11 on HCC growth through in vitro and in vivo assays(MTT assay,colony formation assay,EdU assay,and xenograft model).The molecular mechanism underlying these effects was confirmed by MS2-RIP-assay,RIP assay,luciferase assay,and rescue experiments.Results:RP11-307C12.11 expression level was significantly higher in tumor tissues than in the adjacent normal tissues.Elevated RP11-307C12.11 expression level was associated with poor prognosis of HCC patients,and it may be represented as an independent prognostic biomarker in patients with HCC.Functionally,RP11-307C12.11 overexpression promoted HCC growth both in vitro and in vivo;however,its knockdown reversed these effects.Mechanistically,we found that RP11-307C12.11 expressed predominantly in the cytoplasm and sponged microRNA(miR)-138 to regulate its common target CCND1 and PDK1.Conclusions:Thus,we found that RP11-307C12.11 acts as an oncogene in HCC by binding to miR-138,which might provide a novel target for HCC therapy.展开更多
基金This work was supported by the Ministry of Science and Technology of China[grant number 2017YFA0604002]the National Natural Science Foundation of China[grant numbers 41925023,41575073,41621005,and 91744208]the Collaborative Innovation Center of Climate Change,Jiangsu Province.
文摘The new view denies the existence of fundamental particles in matter, and instead states that any particle and matter is a dynamic superposition of three natural elements, motion, force, and emptiness. This paper proposes a new theory of the structure of matter and the unification of the four forces. A correct understanding of the logic of material structure will enable atomic energy and nuclear physics to generate new manufacturing ideas. The dissertation expounds the natural distribution of dynamics and forces in space and the new deterministic theory of dynamic relationship. This theory solves problems such as the unity of the four forces and the dynamic laws of the material structure. In practical applications, it can provide new theoretical guidance for industrial manufacturing such as nuclear energy, fusion engineering, new energy, new materials, battery energy storage, new-generation reactors, etc., and then adopt effective means in line with the laws of natural power to make the substances needed by human beings. The supply of resources and energy is perfectly satisfied. Applying this theoretical model of material structure to all aspects of the manufacturing industry will surely open up a new era of material civilization for human beings.
基金supported by:the National Natural Science Foundation of China(81702393,81770648,81670601,81570593)Key Scientific and Technological Projects of Guangdong Province(2015B020226004,2017A020215178)+4 种基金Guangdong Natural Science Foundation(2017A030310373,2015A030312013)Science and Technology Planning Project of Guangdong Province(2017B030314027,2017B020209004,2015B020226004)Science and Technology Planning Project of Guangzhou(2014Y2e00544)Guangzhou Science and Technology Huimin Special Project(2014Y2e00200)Sun Yat-sen University Young Teacher Training Project(17ykpy47).
文摘Background:Abnormal expression of long non-coding RNAs(lncRNAs)has been found in almost all tumors in humans,providing numerous potential diagnostic and prognostic biomarkers,and therapeutic targets.Materials and methods:The Cancer Genome Atlas(TCGA)database was used to screen potential LncRNAs,and 30 paired hepatocellular carcinoma(HCC)tissues were used to investigate RP11-307C12.11 expression levels by qRT-PCR and another 105 HCC tissues by in situ hybridizsation(ISH).RP11-307C12.11 overexpression and knockdown experiments were performed to investigate the effects of RP11-307C12.11 on HCC growth through in vitro and in vivo assays(MTT assay,colony formation assay,EdU assay,and xenograft model).The molecular mechanism underlying these effects was confirmed by MS2-RIP-assay,RIP assay,luciferase assay,and rescue experiments.Results:RP11-307C12.11 expression level was significantly higher in tumor tissues than in the adjacent normal tissues.Elevated RP11-307C12.11 expression level was associated with poor prognosis of HCC patients,and it may be represented as an independent prognostic biomarker in patients with HCC.Functionally,RP11-307C12.11 overexpression promoted HCC growth both in vitro and in vivo;however,its knockdown reversed these effects.Mechanistically,we found that RP11-307C12.11 expressed predominantly in the cytoplasm and sponged microRNA(miR)-138 to regulate its common target CCND1 and PDK1.Conclusions:Thus,we found that RP11-307C12.11 acts as an oncogene in HCC by binding to miR-138,which might provide a novel target for HCC therapy.
