Two-dimensional Ruddlesden-Popper(2DRP)perovskite exhibits excellent stability in perovskite solar cells(PSCs)due to introducing hydrophobic long-chain organic spacers.However,the poor charge transporting property of ...Two-dimensional Ruddlesden-Popper(2DRP)perovskite exhibits excellent stability in perovskite solar cells(PSCs)due to introducing hydrophobic long-chain organic spacers.However,the poor charge transporting property of bulky organic cation spacers limits the performance of 2DRP PSCs.Inspired by the Asite cation alloying strategy in 3D perovskites,2DRP perovskites with a binary spacer can promote charge transporting compared to the unary spacer counterparts.Herein,the superior MA-based 2DRP perovskite films with a binary spacer,including 3-guanidinopropanoic acid(GPA)and 4-fluorophenethylamine(FPEA)are realized.These films(GPA_(0.85)FPEA_(0.15))_(2)MA_(4)Pb_5I_(16)show good morphology,large grain size,decreased trap state density,and preferential orientation of the as-prepared film.Accordingly,the present 2DRP-based PSC with the binary spacer achieves a remarkable efficiency of 18.37%with a V_(OC)of1.15 V,a J_(SC)of 20.13 mA cm^(-2),and an FF of 79.23%.To our knowledge,the PCE value should be the highest for binary spacer MA-based 2DRP(n≤5)PSCs to date.Importantly,owing to the hydrophobic fluorine group of FPEA and the enhanced interlayer interaction by FPEA,the unencapsulated 2DRP PSCs based on binary spacers exhibit much excellent humidity stability and thermal stability than the unary spacer counterparts.展开更多
The recently developed hard-magnetic soft(HMS)materials manufactured by embedding high-coercivity micro-particles into soft matrices have received considerable attention from researchers in diverse fields,e.g.,soft ro...The recently developed hard-magnetic soft(HMS)materials manufactured by embedding high-coercivity micro-particles into soft matrices have received considerable attention from researchers in diverse fields,e.g.,soft robotics,flexible electronics,and biomedicine.Theoretical investigations on large deformations of HMS structures are significant foundations of their applications.This work is devoted to developing a powerful theoretical tool for modeling and computing the complicated nonplanar deformations of flexible beams.A so-called quaternion beam model is proposed to break the singularity limitation of the existing geometrically exact(GE)beam model.The singularity-free governing equations for the three-dimensional(3D)large deformations of an HMS beam are first derived,and then solved with the Galerkin discretization method and the trustregion-dogleg iterative algorithm.The correctness of this new model and the utilized algorithms is verified by comparing the present results with the previous ones.The superiority of a quaternion beam model in calculating the complicated large deformations of a flexible beam is shown through several benchmark examples.It is found that the purpose of the HMS beam deformation is to eliminate the direction deviation between the residual magnetization and the applied magnetic field.The proposed new model and the revealed mechanism are supposed to be useful for guiding the engineering applications of flexible structures.展开更多
In order to meet engineering needs of Chinese underground coal mines,a new dust-collecting fan,a device of dust separated by centrifugal force in driven cyclone passageway(DCCP)was designed.In centrifugal dust removal...In order to meet engineering needs of Chinese underground coal mines,a new dust-collecting fan,a device of dust separated by centrifugal force in driven cyclone passageway(DCCP)was designed.In centrifugal dust removal section(CDRS)of DCCP,a general equation is derived from the principle of force equilibrium.According to CDRS structure parameters and fan running parameters,the general equation is simplified,and the simplest equation is calculated numerically by MATLAB.The calculation results illustrate that increasing quantity of air current is against dust removal,but it is beneficial to dust removal by increasing the radius of driven spiral blade and increasing the particle diameter of coal dust.The conclusions show that the dust-collecting structure parameters coupled with the fan running parameters is a novel optimization approach to dust-collection fan for working and heading faces,which is especially suitable for Chinese underground mines.展开更多
Neuroendocrine carcinoma of the breast (NECB) accounts for approximately 0.3%-0.5% of all breast cancers [1, 2]. Due to the rarity of NECB, current understanding of this disease in China is limited to case reports and...Neuroendocrine carcinoma of the breast (NECB) accounts for approximately 0.3%-0.5% of all breast cancers [1, 2]. Due to the rarity of NECB, current understanding of this disease in China is limited to case reports and small case series, and large data analysis is still lacking. Therefore, we conducted the most comprehensive literature search to date, aiming to analyze the clinicopathologic characteristics as well as treatment and outcome of NECB in the Chinese population.展开更多
Objective:Previous studies have shown that exercise suppresses tumor growth.However,the effects of exercise with different intensities and exercise detraining after tumor-bearing on tumor progression remain unclear.Th...Objective:Previous studies have shown that exercise suppresses tumor growth.However,the effects of exercise with different intensities and exercise detraining after tumor-bearing on tumor progression remain unclear.The purpose of this study was to investigate the effects of continuous and disrupted free and exhausted swimming training after tumor-bearing on tumor progression in melanoma B16-F10-bearing C57BL/6 mice.Methods:C57BL/6 mice were subjected to free or exhausted swimming exercise training for 4 weeks prior to the injection of melanoma B16-F10 cells.Subsequently,the B16-F10-bearing mice were maintained with training consisting of free or exhausted swimming or without exercise for 2 weeks during the tumor challenge.Results:The tumor weight was increased by 42%and 109%in mice with 4-week exhausted swimming prior to B16-F10 tumor cells inoculation followed by 2-week training cessation compared with the tumor-bearing control(P<.05)and continuous training groups(P<.01).Tumor weights in groups with exercise detraining after tumor cell inoculation tended to be increased,while the proliferation of splenic T lymphocytes tended to be decreased compared with the group that maintained exercise intensity.After 6-weeks continuous free or exhausted swimming training,the tumor weight of mice was decreased and the proliferation of splenic T lymphocytes was increased compared with the tumor-bearing control group.The frequency of natural killer cells in tumors was increased in all exercise training groups of mice.Conclusions:These results suggest that maintaining exercise intensity after tumor-bearing slows tumor growth in mice,possibly because of the enhanced proliferative activity of splenic lymphocytes rather than natural killer cell infiltration.However,detraining after tumor-bearing might accelerate tumor progression because of the reduced proliferation of splenic T lymphocytes.展开更多
There is no doubt that COVID-19 outbreak is currently the biggest public health threat,which has caused catastrophic con sequences in many countries and regions.As host immunity is key to fighting against virus infect...There is no doubt that COVID-19 outbreak is currently the biggest public health threat,which has caused catastrophic con sequences in many countries and regions.As host immunity is key to fighting against virus infection,it is important to characterize the immunologic changes in the COVID-19 patients,and to explore potential therapeutic candidates.The most efficient ways to end this pandemic are to vaccinate the susceptible population,and to use specific drugs,such as monoclonal antibodies against the viral spike protein(S protein),to treat the affected individuals.Several promising neutralizing antibodies have recently been reported(Cao et al.,2020;Lv et al.,2020).展开更多
Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S...Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S can be recognized by B cell receptor(BCR)or anti-S therapeutic monoclonal antibodies(m Abs)that is the trigger step for B cell activation after S m RNA vaccination or infected cell clearance by S m Abs.Now,a drug strategy to promote S host surface exposure is absent.Here,we first combined structural and biochemical analysis to characterize S COPI sorting signals.A potent S COPI sorting inhibitor was then invented,evidently capable of promoting S surface exposure and facilitating infected cell clearance by S antibody-dependent cellular cytotoxicity(ADCC).Importantly,with the inhibitor as a probe,we revealed Omicron BA.1 S is less cell surface exposed than prototypes because of a constellation of S folding mutations,possibly corresponding to its ER chaperone association.Our findings not only suggest COPI is a druggable target against COVID-19,but also highlight SARS-Co V-2 evolution mechanism driven by S folding and trafficking mutations.展开更多
COVID-19 and its impact on society have raised concerns about scaling up mechanical ventilation(MV)systems and the energy consequences.This paper attempted to combine MV and portable air cleaners(PACs)to achieve accep...COVID-19 and its impact on society have raised concerns about scaling up mechanical ventilation(MV)systems and the energy consequences.This paper attempted to combine MV and portable air cleaners(PACs)to achieve acceptable indoor air quality(IAQ)and energy reduction in two scenarios:regular operation and mitigating the spread of respiratory infectious diseases(RIDs).We proposed a multi-objective optimization method that combined the NSGA-II and TOPSIS techniques to determine the total equivalent ventilation rate of the MV-PAC system in both scenarios.The concentrations of PM_(2.5) and CO_(2) were primary indicators for IAQ.The modified Wells-Riley equation was adopted to predict RID transmissions.An open office with an MV-PAC system was used to demonstrate the method’s applicability.Meanwhile,a field study was conducted to validate the method and evaluate occupants’perceptions of the MV-PAC system.Results showed that optimal solutions of the combined system can be obtained based on various IAQ requirements,seasons,outdoor conditions,etc.For regular operation,PACs were generally prioritized to maintain IAQ while reducing energy consumption even when outdoor PM_(2.5) concentration was high.MV can remain constant or be reduced at low occupancies.In RID scenarios,it is possible to mitigate transmissions when the quanta were<48 h^(−1).No significant difference was found in the subjective perception of the MV and PACs.Moreover,the effects of infiltration on the optimal solution can be substantial.Nonetheless,our results suggested that an MV-PAC system can replace the MV system for offices for daily use and RID mitigation.展开更多
基金financially supported by the Natural Science Foundation of China(Grant Nos.52372226,52173263,62004167)the Natural Science Basic Research Plan in Shaanxi Province of China(Grant Nos.2022JM-315,2023-JC-QN-0643)+4 种基金the National Key R&D Program of China(Grant No.2022YFB3603703)the Qinchuangyuan High-level Talent Project of Shaanxi(Grant No.QCYRCXM-2022-219)the Ningbo Natural Science Foundation(Grant No.2022J061)the Key Research and Development Program of Shaanxi(Grant No.2023GXLH-091)the Shccig-Qinling Program and the Fundamental Research Funds for the Central Universities。
文摘Two-dimensional Ruddlesden-Popper(2DRP)perovskite exhibits excellent stability in perovskite solar cells(PSCs)due to introducing hydrophobic long-chain organic spacers.However,the poor charge transporting property of bulky organic cation spacers limits the performance of 2DRP PSCs.Inspired by the Asite cation alloying strategy in 3D perovskites,2DRP perovskites with a binary spacer can promote charge transporting compared to the unary spacer counterparts.Herein,the superior MA-based 2DRP perovskite films with a binary spacer,including 3-guanidinopropanoic acid(GPA)and 4-fluorophenethylamine(FPEA)are realized.These films(GPA_(0.85)FPEA_(0.15))_(2)MA_(4)Pb_5I_(16)show good morphology,large grain size,decreased trap state density,and preferential orientation of the as-prepared film.Accordingly,the present 2DRP-based PSC with the binary spacer achieves a remarkable efficiency of 18.37%with a V_(OC)of1.15 V,a J_(SC)of 20.13 mA cm^(-2),and an FF of 79.23%.To our knowledge,the PCE value should be the highest for binary spacer MA-based 2DRP(n≤5)PSCs to date.Importantly,owing to the hydrophobic fluorine group of FPEA and the enhanced interlayer interaction by FPEA,the unencapsulated 2DRP PSCs based on binary spacers exhibit much excellent humidity stability and thermal stability than the unary spacer counterparts.
基金Project supported by the National Key Research and Development Program of China(No.2018YFA0703200)the National Natural Science Foundation of China(Nos.52205594 and51820105008)+1 种基金the China National Postdoctoral Program for Innovative Talents(No.BX20220118)the China Postdoctoral Science Foundation(No.2021M701306)。
文摘The recently developed hard-magnetic soft(HMS)materials manufactured by embedding high-coercivity micro-particles into soft matrices have received considerable attention from researchers in diverse fields,e.g.,soft robotics,flexible electronics,and biomedicine.Theoretical investigations on large deformations of HMS structures are significant foundations of their applications.This work is devoted to developing a powerful theoretical tool for modeling and computing the complicated nonplanar deformations of flexible beams.A so-called quaternion beam model is proposed to break the singularity limitation of the existing geometrically exact(GE)beam model.The singularity-free governing equations for the three-dimensional(3D)large deformations of an HMS beam are first derived,and then solved with the Galerkin discretization method and the trustregion-dogleg iterative algorithm.The correctness of this new model and the utilized algorithms is verified by comparing the present results with the previous ones.The superiority of a quaternion beam model in calculating the complicated large deformations of a flexible beam is shown through several benchmark examples.It is found that the purpose of the HMS beam deformation is to eliminate the direction deviation between the residual magnetization and the applied magnetic field.The proposed new model and the revealed mechanism are supposed to be useful for guiding the engineering applications of flexible structures.
基金supported by the National Natural Science Foundation of China and Shenhua Group Corpo-ration Limited(U1361118)the Hunan Provincial Natural Science Foundation of China(13JJ8016)+2 种基金the State Key Laboratory for GeoMechanics and Deep Underground Engineering(SKLG-DUEK1018)the Open Research Fund Program of Hunan Province Key Laboratory of Safe Mining Techniques of Coal Mines(Hunan University of Science and Technology)(201105)the Project of Outstanding(Postgraduate)Dissertation Growth Foundation of HNUST(SNY005).
文摘In order to meet engineering needs of Chinese underground coal mines,a new dust-collecting fan,a device of dust separated by centrifugal force in driven cyclone passageway(DCCP)was designed.In centrifugal dust removal section(CDRS)of DCCP,a general equation is derived from the principle of force equilibrium.According to CDRS structure parameters and fan running parameters,the general equation is simplified,and the simplest equation is calculated numerically by MATLAB.The calculation results illustrate that increasing quantity of air current is against dust removal,but it is beneficial to dust removal by increasing the radius of driven spiral blade and increasing the particle diameter of coal dust.The conclusions show that the dust-collecting structure parameters coupled with the fan running parameters is a novel optimization approach to dust-collection fan for working and heading faces,which is especially suitable for Chinese underground mines.
文摘Neuroendocrine carcinoma of the breast (NECB) accounts for approximately 0.3%-0.5% of all breast cancers [1, 2]. Due to the rarity of NECB, current understanding of this disease in China is limited to case reports and small case series, and large data analysis is still lacking. Therefore, we conducted the most comprehensive literature search to date, aiming to analyze the clinicopathologic characteristics as well as treatment and outcome of NECB in the Chinese population.
基金The authors are grateful to Dr.Qing Wang(University of Kentucky,USA)for her critical reading of the manuscript.
文摘Objective:Previous studies have shown that exercise suppresses tumor growth.However,the effects of exercise with different intensities and exercise detraining after tumor-bearing on tumor progression remain unclear.The purpose of this study was to investigate the effects of continuous and disrupted free and exhausted swimming training after tumor-bearing on tumor progression in melanoma B16-F10-bearing C57BL/6 mice.Methods:C57BL/6 mice were subjected to free or exhausted swimming exercise training for 4 weeks prior to the injection of melanoma B16-F10 cells.Subsequently,the B16-F10-bearing mice were maintained with training consisting of free or exhausted swimming or without exercise for 2 weeks during the tumor challenge.Results:The tumor weight was increased by 42%and 109%in mice with 4-week exhausted swimming prior to B16-F10 tumor cells inoculation followed by 2-week training cessation compared with the tumor-bearing control(P<.05)and continuous training groups(P<.01).Tumor weights in groups with exercise detraining after tumor cell inoculation tended to be increased,while the proliferation of splenic T lymphocytes tended to be decreased compared with the group that maintained exercise intensity.After 6-weeks continuous free or exhausted swimming training,the tumor weight of mice was decreased and the proliferation of splenic T lymphocytes was increased compared with the tumor-bearing control group.The frequency of natural killer cells in tumors was increased in all exercise training groups of mice.Conclusions:These results suggest that maintaining exercise intensity after tumor-bearing slows tumor growth in mice,possibly because of the enhanced proliferative activity of splenic lymphocytes rather than natural killer cell infiltration.However,detraining after tumor-bearing might accelerate tumor progression because of the reduced proliferation of splenic T lymphocytes.
基金This work was funded by the National Natural Science Foundation of China(Nos.61822108,62041102 and 62032007 to Q.J.)the Emergency Research Project for COVID-19 of Harbin Institute of Technology(No.2020-001 to Q.J.)the Scientific Research Project Approved by Heilongjiang Provincial Health Committee(No.2019-253 to J.L.).
文摘There is no doubt that COVID-19 outbreak is currently the biggest public health threat,which has caused catastrophic con sequences in many countries and regions.As host immunity is key to fighting against virus infection,it is important to characterize the immunologic changes in the COVID-19 patients,and to explore potential therapeutic candidates.The most efficient ways to end this pandemic are to vaccinate the susceptible population,and to use specific drugs,such as monoclonal antibodies against the viral spike protein(S protein),to treat the affected individuals.Several promising neutralizing antibodies have recently been reported(Cao et al.,2020;Lv et al.,2020).
基金supported by Startup fund program at Beijing University of Chinese Medicine(BUCM)(90011451310011,China)to Wenfu Mathe emergency fund against COVID-19 program at BUCM(1000061223476,China)to Wenfu Mathe innovation team and talents cultivation program of national administration of traditional Chinese medicine(ZYYCXTD-C202006,China)to Wenfu Ma。
文摘Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S can be recognized by B cell receptor(BCR)or anti-S therapeutic monoclonal antibodies(m Abs)that is the trigger step for B cell activation after S m RNA vaccination or infected cell clearance by S m Abs.Now,a drug strategy to promote S host surface exposure is absent.Here,we first combined structural and biochemical analysis to characterize S COPI sorting signals.A potent S COPI sorting inhibitor was then invented,evidently capable of promoting S surface exposure and facilitating infected cell clearance by S antibody-dependent cellular cytotoxicity(ADCC).Importantly,with the inhibitor as a probe,we revealed Omicron BA.1 S is less cell surface exposed than prototypes because of a constellation of S folding mutations,possibly corresponding to its ER chaperone association.Our findings not only suggest COPI is a druggable target against COVID-19,but also highlight SARS-Co V-2 evolution mechanism driven by S folding and trafficking mutations.
基金supported this project during the 13th Five-year Plan Period(No.2017YFC0702700).
文摘COVID-19 and its impact on society have raised concerns about scaling up mechanical ventilation(MV)systems and the energy consequences.This paper attempted to combine MV and portable air cleaners(PACs)to achieve acceptable indoor air quality(IAQ)and energy reduction in two scenarios:regular operation and mitigating the spread of respiratory infectious diseases(RIDs).We proposed a multi-objective optimization method that combined the NSGA-II and TOPSIS techniques to determine the total equivalent ventilation rate of the MV-PAC system in both scenarios.The concentrations of PM_(2.5) and CO_(2) were primary indicators for IAQ.The modified Wells-Riley equation was adopted to predict RID transmissions.An open office with an MV-PAC system was used to demonstrate the method’s applicability.Meanwhile,a field study was conducted to validate the method and evaluate occupants’perceptions of the MV-PAC system.Results showed that optimal solutions of the combined system can be obtained based on various IAQ requirements,seasons,outdoor conditions,etc.For regular operation,PACs were generally prioritized to maintain IAQ while reducing energy consumption even when outdoor PM_(2.5) concentration was high.MV can remain constant or be reduced at low occupancies.In RID scenarios,it is possible to mitigate transmissions when the quanta were<48 h^(−1).No significant difference was found in the subjective perception of the MV and PACs.Moreover,the effects of infiltration on the optimal solution can be substantial.Nonetheless,our results suggested that an MV-PAC system can replace the MV system for offices for daily use and RID mitigation.