Mesenchymal stromal cells(MSCs),known for their therapeutic bioactivity,find widespread application as cellular drugs for treating various diseases.MSCs obtained from patients or donors require extensive large-scale e...Mesenchymal stromal cells(MSCs),known for their therapeutic bioactivity,find widespread application as cellular drugs for treating various diseases.MSCs obtained from patients or donors require extensive large-scale expansion for clinical applications.However,the conventional method of cultivating MSCs involves several manual processes and yields inconsistent batch-to-batch quality.Consequently,it has not been scalable as a cell therapy[1].To overcome the limitations of conventional planar cell culture,van Wezel initially proposed a system for culturing cells in suspension using microcarriers and successfully proliferated rabbit embryonic skin cells and human embryonic lung cells[2].Subsequently,microcarrier technology has been employed across various pharmaceutical applications,leading to the development and commercialization of a diverse array of microcarriers with distinct physicochemical properties.展开更多
文摘Mesenchymal stromal cells(MSCs),known for their therapeutic bioactivity,find widespread application as cellular drugs for treating various diseases.MSCs obtained from patients or donors require extensive large-scale expansion for clinical applications.However,the conventional method of cultivating MSCs involves several manual processes and yields inconsistent batch-to-batch quality.Consequently,it has not been scalable as a cell therapy[1].To overcome the limitations of conventional planar cell culture,van Wezel initially proposed a system for culturing cells in suspension using microcarriers and successfully proliferated rabbit embryonic skin cells and human embryonic lung cells[2].Subsequently,microcarrier technology has been employed across various pharmaceutical applications,leading to the development and commercialization of a diverse array of microcarriers with distinct physicochemical properties.