Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease with high morbidity and mortality among individuals with diabetes mellitus.Although functional alterations of renal infiltrating immune c...Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease with high morbidity and mortality among individuals with diabetes mellitus.Although functional alterations of renal infiltrating immune cells have been reported as part of the pathological mechanism of DN,the understanding of the immune response underlying peripheral blood mononuclear cells(PBMCs)in DN remains limited.Here,single-cell RNA sequencing(scRNA-seq)was used toprofile the transcriptomic signatures of PBMCs from DN patients.展开更多
基金supported by the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(China)(No.SZGSP001)Shenzhen Governmental Sustainable Development Fund(Guangdong,China)(No.KCXFZ20201221173612034)+3 种基金the National Natural Science Foundation of China(China)(No.82170842)the Natural ScienceFoundation of Shenzhen City(China)(No.KCXFZ20201221173600001)Guangdong Basic and Applied Basic Research Foundation(China)(No.2021A1515012164)Shenzhen Key Laboratory of Kidney Diseases(No.ZDSYS20150430161-6234)。
文摘Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease with high morbidity and mortality among individuals with diabetes mellitus.Although functional alterations of renal infiltrating immune cells have been reported as part of the pathological mechanism of DN,the understanding of the immune response underlying peripheral blood mononuclear cells(PBMCs)in DN remains limited.Here,single-cell RNA sequencing(scRNA-seq)was used toprofile the transcriptomic signatures of PBMCs from DN patients.
