Dear Editor,Microvascular damage is a pivotal pathological factor in lower limb ischemia/reperfusion(I/R)injury.1 Excessive reactive oxygen species(ROS)formation and disrupted autophagic flux have been recognized as t...Dear Editor,Microvascular damage is a pivotal pathological factor in lower limb ischemia/reperfusion(I/R)injury.1 Excessive reactive oxygen species(ROS)formation and disrupted autophagic flux have been recognized as the critical mechanism of cellular death,2,3 especially in I/R injury.Recent investigation has displayed that fibroblast growth factor 21(FGF21)exerts a protective effect against I/R injury via transcription factor EB(TFEB)-mediated autophagy and regulation of anti-oxidative response.4 However,the promising role of FGF21 in acute lower limb I/R injury remains elusive.展开更多
基金National Natural Science Foundation of China(81972150,82172428 To J.X.)Key scientific and technological innovation projects of Wenzhou(ZY20200023 To J.X.)+1 种基金Wenzhou Inovation Team(Growth factor drug development,No.201801)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-028).
文摘Dear Editor,Microvascular damage is a pivotal pathological factor in lower limb ischemia/reperfusion(I/R)injury.1 Excessive reactive oxygen species(ROS)formation and disrupted autophagic flux have been recognized as the critical mechanism of cellular death,2,3 especially in I/R injury.Recent investigation has displayed that fibroblast growth factor 21(FGF21)exerts a protective effect against I/R injury via transcription factor EB(TFEB)-mediated autophagy and regulation of anti-oxidative response.4 However,the promising role of FGF21 in acute lower limb I/R injury remains elusive.
