沙库巴曲缬沙坦防治肿瘤治疗相关心功能不全的效果分析

目的:探讨沙库巴曲缬沙坦治疗肿瘤治疗相关心功能不全(cancer therapy-related cardiac dysfunction,CTRCD)的疗效。方法:汇总分析自建库至2023年3月发表于Pubmed、Web of Science、Cochrane Library、Medline、Embase五大数据库的沙库巴曲缬沙坦治疗CTRCD的所有文献,归纳总结用药时机、剂量、药物疗效等;梳理总结其预防CTRCD的临床研究。结果:使用沙库巴曲缬沙坦治疗CTRCD 3~12个月后,肿瘤患者NYHA心功能从Ⅱ~Ⅳ级改善为Ⅰ~Ⅱ级,LVEF上升幅度为3.0%~37.0%,NTproBNP下降幅度为280.0~65498.0 pg/mL。结论:沙库巴曲缬沙坦治疗CTRCD有效,在改善患者LVEF、GLS等指标方面具有较好的临床应用价值,使肿瘤患者抗肿瘤治疗得以继续、生存期得以延长。

To tune europium valence by controlling the composition in diphase silicate phosphors

Commercial phosphors always require fewer impurities and higher crystallinity, but sometimes it is difficult or strict to synthesize a pure phase compound. Indeed, if the practical application is not influenced, it is acceptable to synthesize a kind of phosphors with diphase matrix that have similar structure and photoluminescence properties. In present work, we designed and synthesized a series of（1-x）BaMSiO4·xBa2 MSi2 O7：Eu（M = Zn2＋, Mg2＋） diphase phosphors which contained two phases BaMSiO4（hexagonal, P63） and Ba2 MSi2 O7（monoclinic, C2/c） by a high temperature solid-state reaction in air condition. The structures and luminescence properties related to the phase transform from BaMSiO4 to Ba2 MSi2 O7 were analyzed carefully. The results show that the self-reduction ability of Eu3＋ is not the best in above four compounds, respectively. But it reaches the maximum and gets the green emission under the UV lamp when the matrix is in a proper ratio of two phases, which suggests that the heterostructure between the two crystals（BaMSiO4 and Ba2 MSi2 O7） improves the self-reduction process of the diphase.The possible mechanism of the tunable europium valence and the luminescent properties in（1-x）BaMSiO4·xBa2 MSi2 O7：Eu phosphors were discussed in detail.

Enhanced N_(2)-to-NH_(3)conversion efficiency on Cu3P nanoribbon electrocatalyst

Ambient electroreduction of nitrogen(N_(2))is considered as a green and feasible approach for ammonia(NH_(3))synthesis,which urgently demands for efficient electrocatalyst.Morphology has close relationship with catalytic activity of heterogeneous catalysts.Nanoribbon is attractive nanostructure,which possesses the flexibility of one-dimensional nanomaterials,the large surface area of two-dimensional nanomaterials,and lateral size confinement effects.In this work,Cu_(3)P nanoribbon is proposed as a highly efficient electrocatalyst for N_(2)-to-NH_(3)conversion under benign conditions.When measured in N_(2)-saturated 0.1 M HCl,such Cu_(3)P nanoribbon achieves high performance with an excellent Faradaic efficiency as high as 37.8%and a large yield of 18.9μg·h^(−1)·mgcat.−1 at−0.2 V.It also demonstrates outstanding stability in long-term electrolysis test at least for 45 h.

Bi nanoparticles/carbon nanosheet composite:A high-efficiency electrocatalyst for NO reduction to NH_(3)

Electrochemical reduction of NO offers us an attractive alternative to traditional selective catalytic reduction process for harmful NO removal and simultaneous NH_(3)production,but it requires efficient electrocatalyst to enable the NO reduction reaction with high selectivity.Here,we report on the development of Bi nanoparticles/carbon nanosheet composite(Bi@C)for highly effective NO reduction electrocatalysis toward selective NH_(3)formation.Such Bi@C catalyst attains an impressive NH_(3)yield of 1,592.5μg·h^(−1)·mgcat.^(−1)and a high Faradaic efficiency as high as 93%in 0.1 M Na_(2)SO_(4)electrolyte.Additionally,it can be applied as efficient cathode materials for Zn–NO battery to reduce NO to NH_(3)with high electricity generation.

A decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries:a systematic review and meta-analysis

Background:Whether smoking is related to a decreased risk of meningioma in women is still controversial.We conducted a systematic review and meta-analysis examining the association between smoking and risk of meningiomas in women.Methods:Two authors independently performed a systematic literature review in the PubMed,Cochrane Library,and EMBASE databases.We identified case-control and cohort studies quantifying associations between smoking and risk of meningioma in women.A meta-analysis by pooling studies was performed according to the multivariate-adjusted risk estimates and 95%confidence intervals(CIs)preferentially.We further conducted additional subgroup and sensitivity analyses to explore possible explanations of the results.Results:A total of seven observational studies were included,with a total of 2132 female patients diagnosed with meningiomas.Ever smoking was associated with a significantly reduced risk of meningioma in women,with pooled odds ratio(OR)of 0.83(95%CI 0.70–0.98).Similar findings were noted for current(OR 0.78,95%CI 0.66–0.93)and past(OR 0.82,95%CI 0.71–0.94)smokers.However,considering the areas,the OR of ever smoking was 0.77(95%CI 0.68–0.87)in three American studies,but 0.99(95%CI 0.73–1.35)in four studies conducted in other countries.Conclusions:Based on limited epidemiological evidence,a decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries.

Fine controllable blue emission and its mechanism in Ce^(3+)-doped orthosilicate solid solution phosphors for different plant growths

The designed Ce^3＋-doped alkaline-earth silicate phosphors CamSr2 m-nBanSiO4：Ce^3＋,Li^＋ （CSBS：Ce^3＋） were synthesized by a high temperature solid-state reaction. The crystal field splitting and the centroid shift from the flee ion energy of 5d configuration were approximated from the spectrum for Ca2SiO4, Sr2SiO4 and Ba2SiO4 phosphors. The single-phase purity was checked by means of X-ray diffraction. Here, when the doped concentration of Ca2. is less than 80% （m 〈 1.6）, we report the structural phase transformation from monoclinic system [3-Ca2Si04 to orthorhombic system α′-Ca2SiO4. The phosphors excited by near-ultraviolet （NUV） light at wavelengths ranging from 200 to 400 nm demonstrate a broad asymmetric blue emission band. The emission peak wavelength redshifts firstly from 417 nm of Ca2SiO4 to 438 nm of Sro.3Cal.6SiO4, and then blueshifts to 411 nm of Sr2SiO4, and the end of 401 nm of Ba2SiOa. These results indicate that the tunable blue-emission of the phosphors can he realized through changing the solid solution components, which has a potential use as a blue component for fabricated precision modulation LEDs light sources and auxiliaries of SSC plastics films for different plant growths. We discuss in detail the possible mechanism and energy diagram of the tunable blue luminescence in CamSr2-M-nBaNSiO4：Ce^3＋.Li^＋ phosphors.