<div style="text-align:justify;"> In view of the shallow buried depth of the target layer and it is difficult to obtain high-quality seismic data of HCX gas storage project, based on the acquisition pa...<div style="text-align:justify;"> In view of the shallow buried depth of the target layer and it is difficult to obtain high-quality seismic data of HCX gas storage project, based on the acquisition parameters of the adjacent area, the 3D acquisition technical scheme is designed for focusing on the imaging of the top of HCX high-steep anticline. By optimizing the acquisition parameters and the excitation and receiving conditions, the acquisition of high-resolution and high signal-to-noise ratio seismic data is guaranteed to meet the demand of fracture prediction and reservoir prediction. </div>展开更多
Li and Mn rich(LMR)layered oxides,written as xLi_(2) MnO_(3)·(1-x)LiMO_(2)(M=Mn,Ni,Co,Fe,etc.),have been widely reported in recent years due to their high capacity and high energy density.The stable structure and...Li and Mn rich(LMR)layered oxides,written as xLi_(2) MnO_(3)·(1-x)LiMO_(2)(M=Mn,Ni,Co,Fe,etc.),have been widely reported in recent years due to their high capacity and high energy density.The stable structure and superior performance of LMR oxides make them one of the most promising candidates for the next-generation cathode materials.However,the commercialization of these materials is hindered by several drawbacks,such as low initial Coulombic efficiency,the degradation of voltage and capacity during cycling,and poor rate performance.This review summarizes research progress in solving these concerns of LMR cathodes over the past decade by following three classes of strategies:morphology design,bulk design,and surface modification.We elaborate on the processing procedures,electrochemical performance,mechanisms,and limitations of each approach,and finally put forward the concerns left and the possible solutions for the commercialization of LMR cathodes.展开更多
YTB block in Sichuan basin is a favorable area to exploit oil and gas in shallow tight rock. 3D seismic project of this zone has two characteristics. Firstly, it has high requirements for the tolerance rate of the con...YTB block in Sichuan basin is a favorable area to exploit oil and gas in shallow tight rock. 3D seismic project of this zone has two characteristics. Firstly, it has high requirements for the tolerance rate of the construction process and the acquisition of high signal-to-noise ratio seismic data;Second, there are widely obstacles and noises that lead to difficult acquisition construction organization. In acquisition practice, high signal-to-noise ratio seismic data was obtained by reasonable design of construction scheme, optimization of excitation parameters, improvement of receiving conditions and optimization of obstacle crossing observation system. .展开更多
Sodium-oxygen batteries(Na-O_(2))have attracted extensive attention as promising energy storage systems due to their high energy density and low cost.Redox mediators are often employed to improve Na-O_(2) battery perf...Sodium-oxygen batteries(Na-O_(2))have attracted extensive attention as promising energy storage systems due to their high energy density and low cost.Redox mediators are often employed to improve Na-O_(2) battery performance,however,their effect on the formation mechanism of the oxygen reduction product(NaO_(2))is still unclear.Here,we have investigated the formation mechanism of NaO_(2) during the discharge process in the presence of a redox mediator with the help of atomic/nano-scale in-situ characterization tools used in concert(e.g.atomic force microscope,electrochemical quartz crystal microbalance(EQCM)and laser nano-particle analyzer).As a result,real-time observations on different time scales show that by shuttling electrons to the electrolyte,the redox mediator enables formation of NaO_(2) in the solution-phase instead of within a finite region near the electrode surface.These findings provide new fundamental insights on the understanding of Na-O_(2) batteries and new consequently perspectives on designing high performance metal-O_(2) batteries and other related functions.展开更多
Design and development of novel electrode materials is one of several hot topics in studying Li ion battery. The CALPHAD(CALculation of PHAse Diagrams) approach enables calculation of stable and metastable phase equil...Design and development of novel electrode materials is one of several hot topics in studying Li ion battery. The CALPHAD(CALculation of PHAse Diagrams) approach enables calculation of stable and metastable phase equilibria,as well as thermodynamic properties for various materials,w hich has been applied to accelerate modern materials design in recent years. The traditional trial-and-error method is being replaced by the integration of CALPHAD with first-principles calculations,as well as empirical methods and key experiments. The CALPHAD approach and first-principles calculations have been proved to be a powerful tool in studying electrode materials, not only for calculation of phase equilibria and thermodynamic properties,but also for prediction of cell voltages in Li ion batteries,which allows for the design of future electrode materials with improved stability and efficiency. Examples of the cathode systems(Li-O,Li-Co-O and Li-Ni-O) and anode systems(Li-Sb and Li-Sn),which are studied by applying the CALPHAD approach and first-principles calculations,are presented.展开更多
We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB)....We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB).We acme energy-efficient technologies for sustainable energy and material recovery and applications.The technologies of thermochemical conversion(TC),biochemical conversion(BC),electrochemical conversion(EC),and photochemical conversion(PTC)are summarized for HALUB.Microalgal biomass could contribute to a biofuel HHV of 35.72 MJ Kg^(-1)and total benefit of 749$/ton biomass via TC.Specific surface area of biochar reached 3000 m^(2)g^(-1)via pyrolytic carbonization of waste bean dregs.Lignocellulosic biomass can be effectively converted into bio-stimulants and biofertilizers via BC with a high conversion efficiency of more than 90%.Besides,lignocellulosic biomass can contribute to a current density of 672 mA m^(-2)via EC.Bioresource can be 100%selectively synthesized via electrocatalysis through EC and PTC.Machine learning,techno-economic analysis,and life cycle analysis are essential to various upgrading approaches of HALUB.Sustainable biomaterials,sustainable living materials and technologies for biomedical and multifunctional applications like nano-catalysis,microfluidic and micro/nanomotors beyond are also highlighted.New techniques and systems for the complete conversion and utilization of HALUB for new energy and materials are further discussed.展开更多
Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and...Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and which is conducive to the protection of the ecological environment and sustainable devel-opment of agriculture.Therefore,it is imperative to develop and use CRFs as an alternative to traditional fertilizers.This review aims to present the classification,raw material composition,benefits,release process,release mode,and manufacturing methods of fertilizers coated with organic-inorganic com-posite membranes(OICMs)in order to provide an overall update and summarize CRFs encapsulated by OICMs and provide an insight for future trends in the field of fertilizers.It is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.展开更多
Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment.Herein,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“prec...Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment.Herein,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“precise strike”of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid(HA)and hypoxia-dependent factor carbonic anhydrase IX(CA IX)-inhibitor acetazolamide(AZ).The core of nanobullets is the special zinc(II)phthalocyanine aggregates(ZPA)which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy(PTT),along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy(TDT).The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional(reactive oxygen species(ROS)-mediated)cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis.展开更多
Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are essential causes of death and long-term disability and are difficult to cure,mainly due to the limited neuron rege...Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are essential causes of death and long-term disability and are difficult to cure,mainly due to the limited neuron regeneration and the glial scar formation.Herein,we apply extracellular vesicles(EVs)secreted by M2 microglia to improve the differentiation of neural stem cells(NSCs)at the injured site,and simultaneously modify them with the injured vascular targeting peptide(DA7R)and the stem cell recruiting factor(SDF-1)on their surface via copper-free click chemistry to recruit NSCs,inducing their neuronal differentiation,and serving as the nanocarriers at the injured site(Dual-EV).Results prove that the Dual-EV could target human umbilical vascular endothelial cells(HUVECs),recruit NSCs,and promote the neuronal differentiation of NSCs in vitro.Furthermore,10 miRNAs are found to be upregulated in Dual-M2-EVs compared to Dual-M0-EVs via bioinformatic analysis,and further NSC differentiation experiment by flow cytometry reveals that among these miRNAs,miR30b-3p,miR-222-3p,miR-129-5p,and miR-155-5p may exert effect of inducing NSC to differentiate into neurons.In vivo experiments show that Dual-EV nanocarriers achieve improved accumulation in the ischemic area of stroke model mice,potentiate NSCs recruitment,and increase neurogenesis.This work provides new insights for the treatment of neuronal regeneration after CNS injuries as well as endogenous stem cells,and the click chemistry EV/peptide/chemokine and related nanocarriers for improving human health.展开更多
Evidence suggests that explicit reappraisal has limited regulatory effects on high-intensity emotions,mainly due to the depletion of cognitive resources occupied by the high-intensity emotional stimulus itself.The imp...Evidence suggests that explicit reappraisal has limited regulatory effects on high-intensity emotions,mainly due to the depletion of cognitive resources occupied by the high-intensity emotional stimulus itself.The implicit form of reappraisal has proved to be resource-saving and therefore might be an ideal strategy to achieve the desired regulatory effect in high-intensity situations.In this study,we explored the regulatory effect of explicit and implicit reappraisal when participants encountered low-and high-intensity negative images.The subjective emotional rating indicated that both explicit and implicit reappraisal down-regulated negative experiences,irrespective of intensity.However,the amplitude of the parietal late positive potential(LPP;a neural index of experienced emotional intensity)showed that only implicit reappraisal had significant regulatory effects in the high-intensity context,though both explicit and implicit reappraisal successfully reduced the emotional neural responses elicited by low-intensity negative images.Meanwhile,implicit reappraisal led to a smaller frontal LPP amplitude(an index of cognitive cost)compared to explicit reappraisal,indicating that the implementation of implicit reappraisal consumes limited cognitive control resources.Furthermore,we found a prolonged effect of implicit emotion regulation introduced by training procedures.Taken together,these findings not only reveal that implicit reappraisal is suitable to relieve high-intensity negative experiences as well as neural responses,but also highlight the potential benefit of trained implicit regulation in clinical populations whose frontal control resources are limited.展开更多
As a van der Waals ferromagnet with high Curie temperature,Fe_(5-x)GeTe_(2) has attracted tremendous interests recently.Here,using high-resolution angle-resolved photoemission spectroscopy(ARPES),we systematically inv...As a van der Waals ferromagnet with high Curie temperature,Fe_(5-x)GeTe_(2) has attracted tremendous interests recently.Here,using high-resolution angle-resolved photoemission spectroscopy(ARPES),we systematically investigated the electronic structure of Fe_(5-x)GeTe_(2) crystals and its temperature evolution.Our ARPES measurement reveals two types of band structures from two different terminations with slight kz evolution.Interestingly,across the ferromagnetic transition,we observed the merging of two split bands above the Curie temperature,suggesting the band splitting due to the exchange interaction within the itinerant Stoner model.Our results provide important insights into the electronic and magnetic properties of Fe_(5-x)GeTe_(2) and the understanding of magnetism in a two-dimensional ferromagnetic system.展开更多
After Google reported its realization of quantum supremacy,Solving the classical problems with quantum computing is becoming a valuable research topic.Switching function minimization is an important problem in Electro...After Google reported its realization of quantum supremacy,Solving the classical problems with quantum computing is becoming a valuable research topic.Switching function minimization is an important problem in Electronic Design Automation(EDA)and logic synthesis,most of the solutions are based on heuristic algorithms with a classical computer,it is a good practice to solve this problem with a quantum processer.In this paper,we introduce a new hybrid classic quantum algorithm using Grover’s algorithm and symmetric functions to minimize small Disjoint Sum of Product(DSOP)and Sum of Product(SOP)for Boolean switching functions.Our method is based on graph partitions for arbitrary graphs to regular graphs,which can be solved by a Grover-based quantum searching algorithm we proposed.The Oracle for this quantum algorithm is built from Boolean symmetric functions and implemented with Lattice diagrams.It is shown analytically and verified by simulations on a quantum simulator that our methods can find all solutions to these problems.展开更多
Graphite as a positive electrode material of dual ion batteries(DIBs)has attracted tremendous attentions for its advantages including low lost,high working voltage and high energy density.However,very few literatures ...Graphite as a positive electrode material of dual ion batteries(DIBs)has attracted tremendous attentions for its advantages including low lost,high working voltage and high energy density.However,very few literatures regarding to the real-time observation of anion intercalation behavior and surface evolution of graphite in DIBs have been reported.Herein,we use in situ atomic force microscope(AFM)to directly observe the intercalation/de-intercalation processes of PF6^-in graphite in real time.First,by measuring the change in the distance between graphene layers during intercalation,we found that PF6^-intercalates in one of every three graphite layers and the intercalation speed is measured to be 2μm-min^-1.Second,graphite will wrinke and suffer structural damnages at high voltages,along with severe electrolyte decomposition on the surface.These findings provide useful information for further optimizing the capacity and the stability of graphite anode in DIBs.展开更多
The cellular response to the complex extracellular microenvironment is highly dynamic in time and type of extracellular matrix.Accurately reconstructing this process and analyzing the changes in receptor conformation ...The cellular response to the complex extracellular microenvironment is highly dynamic in time and type of extracellular matrix.Accurately reconstructing this process and analyzing the changes in receptor conformation on the cell membrane surface and intracellular or intercellular signaling has been a major challenge in analytical chemistry and biophysical methodology.In this paper,a time-coded multiconcentration microfluidic chemical waveform generator was developed for the dynamic signaling probing with single-cell array of high temporal resolution,high throughput,and multi-concentration combination stimulation.Based on innovative microchannel structure,sophisticated external control methods and multiplexing technology,the system not only allowed for temporally sequential permutations of the four concentrations of stimuli(time code),but also generated pulsed and continuous waveforms at different frequencies in a highly controllable manner.Furthermore,the single-cell trap array was set up to efficiently capture cells in suspension,dramatically increasing throughput and reducing experiment preparation time.The maximum frequency of the platform was 1 Hz,and one cell could be stimulated at multiple frequencies.To show the ability of the system to investigate rapid biochemical events in high throughput,pulse stimulation and continuous stimulation of different frequencies and different time codes,combined with four concentrations of histamine(HA),were generated for probing G protein-coupled receptor(GPCR)signaling in He La cells.Then,statistical analysis was performed for the mean peak height and mean peak area of the cellular response.We believe that the time-coded multi-concentration microfluidic chemical waveform generator will provide a novel strategy for analytical chemistry,biophysics,cell signaling,and individualized medicine applications.展开更多
This study investigates the mediation effects of online public attention on the relationship between air pollution and precautionary behavior based on a merged real-world data set that includes daily air quality,Inter...This study investigates the mediation effects of online public attention on the relationship between air pollution and precautionary behavior based on a merged real-world data set that includes daily air quality,Internet search and media indices,social media discussions,and product purchases.Using a Bayesian structural equation modeling approach,we show that online public attention to air pollution increases when air pollution increases,and such attention is captured by more media reports,social media discussions,and Internet searches.A comprehensive relationship involving direct and indirect effects between air pollution and precautionary behavior is established.Air pollution has a positive effect on proactive defensive behaviors,reflected in increased purchases of preventive products,and this effect is partially mediated by online media coverage and the public's Internet searches.Air pollution also motivates passive defensive behaviors,reflected in decreased purchases of outdoor sports products,and this effect is partially mediated by social media coverage.These results suggest that governments could improve the quality of policy making by considering the different roles of various forms of online public attention in the public's risk perceptions of and reactions to air pollution.展开更多
Optical microcavities offer a promising platform for highly efficient light–matter interactions.Recently,the combination of microresonators and 2D materials in the nanoscale has further enriched the optoelectronics o...Optical microcavities offer a promising platform for highly efficient light–matter interactions.Recently,the combination of microresonators and 2D materials in the nanoscale has further enriched the optoelectronics of microcavity geometries,spurring broad advances including lasers,nonlinear converters,modulators,and sensors.Here,we report the concept of compact dual-laser cogeneration in a graphene-microcavity fiber,which offers a way to cancel the optical common mode noises.Driven by a single 980 nm pump,orthogonally polarized laser lines are generated in a pair of degeneracy breaking modes.The two laser lines produce a heterodyne beat note at 118.96 MHz,with frequency noise down to 200 Hz~2∕Hz at 1 MHz offset,demonstrating a linewidth of 930 Hz in vacuum.This compact device enables on-line and label-free NH_(3) gas detection with high resolution,realizing a detection limit on a single pmol/L level,and a capability to quantitatively trace gas–graphene interactions.Such a combination of graphene optoelectronics and microcavity photonics demonstrates a novel physical paradigm for microlaser control and offers a new scheme for in situ chemical sensing.展开更多
Fabrication of biocompatible core-shell microcapsules in a controllable and scalable manner remains an important but challenging task.Here,we develop a one-step microfluidic approach for the highthroughput production ...Fabrication of biocompatible core-shell microcapsules in a controllable and scalable manner remains an important but challenging task.Here,we develop a one-step microfluidic approach for the highthroughput production of biocompatible microcapsules,which utilizes single emulsions as templates and controls the precipitation of biocompatible polymer at the water/oil interface.The facile method enables the loading of various oils in the core and the enhancement of polymer shell strength by polyelectrolyte coating.The resulting microcapsules have the advantages of controllability,scalability,biocompatibility,high encapsulation efficiency and high loading capacity.The core-shell microcapsules are ideal delivery vehicles for programmable active release and various controlled release mechanisms are demonstrated,including burst release by vigorous shaking,pH-triggered release for targeted intestinal release and sustained release of perfume over a long period of time.The utility of our technique paves the way for practical applications of core-shell microcapsules.展开更多
The combination of optical fiber with graphene has greatly expanded the application regimes of fiber optics,from dynamic optical control and ultrafast pulse generation to high precision sensing.However,limited by fabr...The combination of optical fiber with graphene has greatly expanded the application regimes of fiber optics,from dynamic optical control and ultrafast pulse generation to high precision sensing.However,limited by fabrication,previous graphene-fiber samples are typically limited in the micrometer to centimeter scale,which cannot take the inherent advantage of optical fibers—longdistance optical transmission.Here,we demonstrate kilometers long graphene-coated optical fiber(GCF)based on industrial graphene nanosheets and coating technique.The GCF shows unusually high thermal diffusivity of 24.99 mm^(2) s^(-1) in the axial direction,measured by a thermal imager directly.This enables rapid thermooptical response both in optical fiber Bragg grating sensors at one point(18-fold faster than conventional fiber)and in long-distance distributed fiber sensing systems based on backward Rayleigh scattering in optical fiber(15-fold faster than conventional fiber).This work realizes the industrial-level graphene-fiber production and provides a novel platform for two-dimensional material-based optical fiber sensing applications.展开更多
文摘<div style="text-align:justify;"> In view of the shallow buried depth of the target layer and it is difficult to obtain high-quality seismic data of HCX gas storage project, based on the acquisition parameters of the adjacent area, the 3D acquisition technical scheme is designed for focusing on the imaging of the top of HCX high-steep anticline. By optimizing the acquisition parameters and the excitation and receiving conditions, the acquisition of high-resolution and high signal-to-noise ratio seismic data is guaranteed to meet the demand of fracture prediction and reservoir prediction. </div>
基金financially supported by the National Key R&D Program of China(2016YFB0700600)the Soft Science Research Project of Guangdong Province(No.2017B030301013)the Shenzhen Science and Technology Research Grant(ZDSYS201707281026184)。
文摘Li and Mn rich(LMR)layered oxides,written as xLi_(2) MnO_(3)·(1-x)LiMO_(2)(M=Mn,Ni,Co,Fe,etc.),have been widely reported in recent years due to their high capacity and high energy density.The stable structure and superior performance of LMR oxides make them one of the most promising candidates for the next-generation cathode materials.However,the commercialization of these materials is hindered by several drawbacks,such as low initial Coulombic efficiency,the degradation of voltage and capacity during cycling,and poor rate performance.This review summarizes research progress in solving these concerns of LMR cathodes over the past decade by following three classes of strategies:morphology design,bulk design,and surface modification.We elaborate on the processing procedures,electrochemical performance,mechanisms,and limitations of each approach,and finally put forward the concerns left and the possible solutions for the commercialization of LMR cathodes.
文摘YTB block in Sichuan basin is a favorable area to exploit oil and gas in shallow tight rock. 3D seismic project of this zone has two characteristics. Firstly, it has high requirements for the tolerance rate of the construction process and the acquisition of high signal-to-noise ratio seismic data;Second, there are widely obstacles and noises that lead to difficult acquisition construction organization. In acquisition practice, high signal-to-noise ratio seismic data was obtained by reasonable design of construction scheme, optimization of excitation parameters, improvement of receiving conditions and optimization of obstacle crossing observation system. .
基金financially supported by Soft Science Research Project of Guangdong Province(No.2017B030301013)the Shenzhen Science and Technology Research(Grant No.JCYJ20170818085823773,ZDSYS201707281026184)+1 种基金China Postdoctoral Science Foundation(2019M660317)the National Science Foundation of China(No.U1864213)。
文摘Sodium-oxygen batteries(Na-O_(2))have attracted extensive attention as promising energy storage systems due to their high energy density and low cost.Redox mediators are often employed to improve Na-O_(2) battery performance,however,their effect on the formation mechanism of the oxygen reduction product(NaO_(2))is still unclear.Here,we have investigated the formation mechanism of NaO_(2) during the discharge process in the presence of a redox mediator with the help of atomic/nano-scale in-situ characterization tools used in concert(e.g.atomic force microscope,electrochemical quartz crystal microbalance(EQCM)and laser nano-particle analyzer).As a result,real-time observations on different time scales show that by shuttling electrons to the electrolyte,the redox mediator enables formation of NaO_(2) in the solution-phase instead of within a finite region near the electrode surface.These findings provide new fundamental insights on the understanding of Na-O_(2) batteries and new consequently perspectives on designing high performance metal-O_(2) batteries and other related functions.
基金Sponsored by the National Natural Science Foundation of China(Grant Nos.51531009 and 51671219)Natural Science Foundation of Hunan Province(Grant No.2017JJ3409)the Deutsche Forschungsgemeinschaft(DFG)CH-1688/1-1 and Nachwuchsakademie Program
文摘Design and development of novel electrode materials is one of several hot topics in studying Li ion battery. The CALPHAD(CALculation of PHAse Diagrams) approach enables calculation of stable and metastable phase equilibria,as well as thermodynamic properties for various materials,w hich has been applied to accelerate modern materials design in recent years. The traditional trial-and-error method is being replaced by the integration of CALPHAD with first-principles calculations,as well as empirical methods and key experiments. The CALPHAD approach and first-principles calculations have been proved to be a powerful tool in studying electrode materials, not only for calculation of phase equilibria and thermodynamic properties,but also for prediction of cell voltages in Li ion batteries,which allows for the design of future electrode materials with improved stability and efficiency. Examples of the cathode systems(Li-O,Li-Co-O and Li-Ni-O) and anode systems(Li-Sb and Li-Sn),which are studied by applying the CALPHAD approach and first-principles calculations,are presented.
基金the support from Harvard/MITthe support funded by the National Research Foundation(NRF),Prime Minister’s Office,Singapore,under its Campus for Research Excellence and Technological Enterprise(CREATE)program,Grant Number R-706-001-102-281the funding support from Harbin Institute of Technology,China,Grant Number FRFCU5710053121。
文摘We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB).We acme energy-efficient technologies for sustainable energy and material recovery and applications.The technologies of thermochemical conversion(TC),biochemical conversion(BC),electrochemical conversion(EC),and photochemical conversion(PTC)are summarized for HALUB.Microalgal biomass could contribute to a biofuel HHV of 35.72 MJ Kg^(-1)and total benefit of 749$/ton biomass via TC.Specific surface area of biochar reached 3000 m^(2)g^(-1)via pyrolytic carbonization of waste bean dregs.Lignocellulosic biomass can be effectively converted into bio-stimulants and biofertilizers via BC with a high conversion efficiency of more than 90%.Besides,lignocellulosic biomass can contribute to a current density of 672 mA m^(-2)via EC.Bioresource can be 100%selectively synthesized via electrocatalysis through EC and PTC.Machine learning,techno-economic analysis,and life cycle analysis are essential to various upgrading approaches of HALUB.Sustainable biomaterials,sustainable living materials and technologies for biomedical and multifunctional applications like nano-catalysis,microfluidic and micro/nanomotors beyond are also highlighted.New techniques and systems for the complete conversion and utilization of HALUB for new energy and materials are further discussed.
基金funded by the Key Project of the Science and Technology Department of Jilin Province,China(grant No.20220203079SF)Independent Research Project in 2020 of State Key Laboratory of Supramolecular Structure and Materials(grant No.CXKT202008).
文摘Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and which is conducive to the protection of the ecological environment and sustainable devel-opment of agriculture.Therefore,it is imperative to develop and use CRFs as an alternative to traditional fertilizers.This review aims to present the classification,raw material composition,benefits,release process,release mode,and manufacturing methods of fertilizers coated with organic-inorganic com-posite membranes(OICMs)in order to provide an overall update and summarize CRFs encapsulated by OICMs and provide an insight for future trends in the field of fertilizers.It is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.
基金the National Natural Science Foundation of China(51903203,51703178,81770728)the China Postdoctoral Science Foundation(2019M653661,2019M663742)+3 种基金the Natural Science Foundation of Shaanxi Province(2020JQ-046)Natural Science Foundation of Zhejiang Province(LWY20H180002)the Natural Science Foundation of Guangxi Zhuang Autonomous Region(2017GXNSFBA198028).Y.H.,M.G.,Y.S.Z.,G.H.and X.Z.were not supported by any of these fundsinstead,support by MIT,Harvard,Stanford University and the Brigham Research Institute are acknowledged.
文摘Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment.Herein,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“precise strike”of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid(HA)and hypoxia-dependent factor carbonic anhydrase IX(CA IX)-inhibitor acetazolamide(AZ).The core of nanobullets is the special zinc(II)phthalocyanine aggregates(ZPA)which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy(PTT),along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy(TDT).The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional(reactive oxygen species(ROS)-mediated)cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis.
基金support from Harvard/MITsupport by grants from the National Key R&D Program of China(2019YFA0112000)+5 种基金National Natural Science Foundation of China(Nos.81930051,82003658,81801170)the Interdisciplinary Program of Shanghai Jiao Tong University(ZH2018ZDA04,China)Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20171906,China)China Postdoctoral Science Foundation(2019M661546)National Postdoctoral Program for Innovative Talents(BX20200212,China)Zhejiang Provincial Natural Science Foundation of China(No.LQ21H300009,China)。
文摘Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are essential causes of death and long-term disability and are difficult to cure,mainly due to the limited neuron regeneration and the glial scar formation.Herein,we apply extracellular vesicles(EVs)secreted by M2 microglia to improve the differentiation of neural stem cells(NSCs)at the injured site,and simultaneously modify them with the injured vascular targeting peptide(DA7R)and the stem cell recruiting factor(SDF-1)on their surface via copper-free click chemistry to recruit NSCs,inducing their neuronal differentiation,and serving as the nanocarriers at the injured site(Dual-EV).Results prove that the Dual-EV could target human umbilical vascular endothelial cells(HUVECs),recruit NSCs,and promote the neuronal differentiation of NSCs in vitro.Furthermore,10 miRNAs are found to be upregulated in Dual-M2-EVs compared to Dual-M0-EVs via bioinformatic analysis,and further NSC differentiation experiment by flow cytometry reveals that among these miRNAs,miR30b-3p,miR-222-3p,miR-129-5p,and miR-155-5p may exert effect of inducing NSC to differentiate into neurons.In vivo experiments show that Dual-EV nanocarriers achieve improved accumulation in the ischemic area of stroke model mice,potentiate NSCs recruitment,and increase neurogenesis.This work provides new insights for the treatment of neuronal regeneration after CNS injuries as well as endogenous stem cells,and the click chemistry EV/peptide/chemokine and related nanocarriers for improving human health.
基金supported by the National Natural Science Foundation of China(32271102,31970980,31920103009)the Major Project of the National Social Science Foundation(20&ZD153)+1 种基金the Shenzhen-Hong Kong Institute of Brain Science(2022SHIBS0003)the Guangdong Key Project(2018B030335001).
文摘Evidence suggests that explicit reappraisal has limited regulatory effects on high-intensity emotions,mainly due to the depletion of cognitive resources occupied by the high-intensity emotional stimulus itself.The implicit form of reappraisal has proved to be resource-saving and therefore might be an ideal strategy to achieve the desired regulatory effect in high-intensity situations.In this study,we explored the regulatory effect of explicit and implicit reappraisal when participants encountered low-and high-intensity negative images.The subjective emotional rating indicated that both explicit and implicit reappraisal down-regulated negative experiences,irrespective of intensity.However,the amplitude of the parietal late positive potential(LPP;a neural index of experienced emotional intensity)showed that only implicit reappraisal had significant regulatory effects in the high-intensity context,though both explicit and implicit reappraisal successfully reduced the emotional neural responses elicited by low-intensity negative images.Meanwhile,implicit reappraisal led to a smaller frontal LPP amplitude(an index of cognitive cost)compared to explicit reappraisal,indicating that the implementation of implicit reappraisal consumes limited cognitive control resources.Furthermore,we found a prolonged effect of implicit emotion regulation introduced by training procedures.Taken together,these findings not only reveal that implicit reappraisal is suitable to relieve high-intensity negative experiences as well as neural responses,but also highlight the potential benefit of trained implicit regulation in clinical populations whose frontal control resources are limited.
基金the National Key R&D Program of China(Grant No.2017YFA0305400)。
文摘As a van der Waals ferromagnet with high Curie temperature,Fe_(5-x)GeTe_(2) has attracted tremendous interests recently.Here,using high-resolution angle-resolved photoemission spectroscopy(ARPES),we systematically investigated the electronic structure of Fe_(5-x)GeTe_(2) crystals and its temperature evolution.Our ARPES measurement reveals two types of band structures from two different terminations with slight kz evolution.Interestingly,across the ferromagnetic transition,we observed the merging of two split bands above the Curie temperature,suggesting the band splitting due to the exchange interaction within the itinerant Stoner model.Our results provide important insights into the electronic and magnetic properties of Fe_(5-x)GeTe_(2) and the understanding of magnetism in a two-dimensional ferromagnetic system.
文摘After Google reported its realization of quantum supremacy,Solving the classical problems with quantum computing is becoming a valuable research topic.Switching function minimization is an important problem in Electronic Design Automation(EDA)and logic synthesis,most of the solutions are based on heuristic algorithms with a classical computer,it is a good practice to solve this problem with a quantum processer.In this paper,we introduce a new hybrid classic quantum algorithm using Grover’s algorithm and symmetric functions to minimize small Disjoint Sum of Product(DSOP)and Sum of Product(SOP)for Boolean switching functions.Our method is based on graph partitions for arbitrary graphs to regular graphs,which can be solved by a Grover-based quantum searching algorithm we proposed.The Oracle for this quantum algorithm is built from Boolean symmetric functions and implemented with Lattice diagrams.It is shown analytically and verified by simulations on a quantum simulator that our methods can find all solutions to these problems.
基金This research was financially supported by Soft Science Research Project of Guangdong Province(No.2017B030301013)the Shenzhen Science and Technology Research(Nos.CYJ20170818085823773 and ZDSYS201707281026184).
文摘Graphite as a positive electrode material of dual ion batteries(DIBs)has attracted tremendous attentions for its advantages including low lost,high working voltage and high energy density.However,very few literatures regarding to the real-time observation of anion intercalation behavior and surface evolution of graphite in DIBs have been reported.Herein,we use in situ atomic force microscope(AFM)to directly observe the intercalation/de-intercalation processes of PF6^-in graphite in real time.First,by measuring the change in the distance between graphene layers during intercalation,we found that PF6^-intercalates in one of every three graphite layers and the intercalation speed is measured to be 2μm-min^-1.Second,graphite will wrinke and suffer structural damnages at high voltages,along with severe electrolyte decomposition on the surface.These findings provide useful information for further optimizing the capacity and the stability of graphite anode in DIBs.
基金the National Natural Science Foundation of China(Nos.22074047,21775049 and 31700746)the Hubei Provincial Natural Science Foundation of China(No.2020CFB578)the Fundamental Research Funds for Central Universities,HUST(Nos.2020kfy XJJS034 and 2021GCRC056)。
文摘The cellular response to the complex extracellular microenvironment is highly dynamic in time and type of extracellular matrix.Accurately reconstructing this process and analyzing the changes in receptor conformation on the cell membrane surface and intracellular or intercellular signaling has been a major challenge in analytical chemistry and biophysical methodology.In this paper,a time-coded multiconcentration microfluidic chemical waveform generator was developed for the dynamic signaling probing with single-cell array of high temporal resolution,high throughput,and multi-concentration combination stimulation.Based on innovative microchannel structure,sophisticated external control methods and multiplexing technology,the system not only allowed for temporally sequential permutations of the four concentrations of stimuli(time code),but also generated pulsed and continuous waveforms at different frequencies in a highly controllable manner.Furthermore,the single-cell trap array was set up to efficiently capture cells in suspension,dramatically increasing throughput and reducing experiment preparation time.The maximum frequency of the platform was 1 Hz,and one cell could be stimulated at multiple frequencies.To show the ability of the system to investigate rapid biochemical events in high throughput,pulse stimulation and continuous stimulation of different frequencies and different time codes,combined with four concentrations of histamine(HA),were generated for probing G protein-coupled receptor(GPCR)signaling in He La cells.Then,statistical analysis was performed for the mean peak height and mean peak area of the cellular response.We believe that the time-coded multi-concentration microfluidic chemical waveform generator will provide a novel strategy for analytical chemistry,biophysics,cell signaling,and individualized medicine applications.
基金Dr.Xu and Dr.Feng contributed equally to this work.Dr.Xu's work was partially supported by the National Natural Science Foundation of China(71704052 and 72074072)the Natural Science Foundation of Hunan Province,China(2018JJ3263)+5 种基金the Research Foundation of Education Bureau of Hunan Province,China(18B334)Dr.Feng's work was partially supported by the National Natural Science Foundation of China(71802166)the Humanities and Social Science Foundation of the Ministry of Education of China(20YJC630055)Dr.Li's work was partially supported by the LamWoo Research Fund(LWI20005)Faculty Research Grant(DB20A3 and DB21A7)Direct Grant(DR21B3).
文摘This study investigates the mediation effects of online public attention on the relationship between air pollution and precautionary behavior based on a merged real-world data set that includes daily air quality,Internet search and media indices,social media discussions,and product purchases.Using a Bayesian structural equation modeling approach,we show that online public attention to air pollution increases when air pollution increases,and such attention is captured by more media reports,social media discussions,and Internet searches.A comprehensive relationship involving direct and indirect effects between air pollution and precautionary behavior is established.Air pollution has a positive effect on proactive defensive behaviors,reflected in increased purchases of preventive products,and this effect is partially mediated by online media coverage and the public's Internet searches.Air pollution also motivates passive defensive behaviors,reflected in decreased purchases of outdoor sports products,and this effect is partially mediated by social media coverage.These results suggest that governments could improve the quality of policy making by considering the different roles of various forms of online public attention in the public's risk perceptions of and reactions to air pollution.
基金National Key Research and Development Program of China(2021YFB2800602)National Natural Science Foundation of China(61975025,U2130106)State Key Laboratory Open Program(2022GZKF002)。
文摘Optical microcavities offer a promising platform for highly efficient light–matter interactions.Recently,the combination of microresonators and 2D materials in the nanoscale has further enriched the optoelectronics of microcavity geometries,spurring broad advances including lasers,nonlinear converters,modulators,and sensors.Here,we report the concept of compact dual-laser cogeneration in a graphene-microcavity fiber,which offers a way to cancel the optical common mode noises.Driven by a single 980 nm pump,orthogonally polarized laser lines are generated in a pair of degeneracy breaking modes.The two laser lines produce a heterodyne beat note at 118.96 MHz,with frequency noise down to 200 Hz~2∕Hz at 1 MHz offset,demonstrating a linewidth of 930 Hz in vacuum.This compact device enables on-line and label-free NH_(3) gas detection with high resolution,realizing a detection limit on a single pmol/L level,and a capability to quantitatively trace gas–graphene interactions.Such a combination of graphene optoelectronics and microcavity photonics demonstrates a novel physical paradigm for microlaser control and offers a new scheme for in situ chemical sensing.
基金supported by the National Key R&D Program of China(2017YFA0305400 and 2019YFA0704900)Chinese Academy of Sciences-Shanghai Science Research Center(CAS-SSRC-YH2015-01)+9 种基金Double First-Class Initiative Fund of Shanghai Tech Universitythe support from the Engineering and Physical Sciences Research Council Platform Grant(EP/M020517/1)the Major Research Plan of the National Natural Science Foundation of China(NSFC,92065201)Shanghai Municipal Science and Technology Major Project(2018SHZDZX02)the support from the NSFC(52088101 and 11974394)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(XDB33000000)the support from Shanghai Committee of Science and Technology(22ZR1441800)Shanghai-XFEL Beamline Project(SBP)(31011505505885920161A2101001)the support from the NSFC(12004248)and the support from the NSFC(12104304)Shanghai Sailing Program(20YF1430500)。
基金supported by the National Natural Science Foundation of China (Nos.21878258 and 11704331)"theFundamental Research Funds for the Central Universities" (No. 2018QNA4046)+2 种基金the Youth Funds of the State Key Laboratory of Fluid Power and Mechatronic Systems (Zhejiang University)supported by the National Science Foundation (No. DMR-1310266)the Harvard Materials Research Science and Engineering Center (No.DMR-1420570)
文摘Fabrication of biocompatible core-shell microcapsules in a controllable and scalable manner remains an important but challenging task.Here,we develop a one-step microfluidic approach for the highthroughput production of biocompatible microcapsules,which utilizes single emulsions as templates and controls the precipitation of biocompatible polymer at the water/oil interface.The facile method enables the loading of various oils in the core and the enhancement of polymer shell strength by polyelectrolyte coating.The resulting microcapsules have the advantages of controllability,scalability,biocompatibility,high encapsulation efficiency and high loading capacity.The core-shell microcapsules are ideal delivery vehicles for programmable active release and various controlled release mechanisms are demonstrated,including burst release by vigorous shaking,pH-triggered release for targeted intestinal release and sustained release of perfume over a long period of time.The utility of our technique paves the way for practical applications of core-shell microcapsules.
基金supported by the National Key Research and Development Program of China (2017YFA0305400, 2017YFA0304600, 2018YFA0307100, and 2018YFA0305603)the National Natural Science Foundation of China (11774190, 11674229, 11634009, 11774427, 51788104, and 11874035)+1 种基金EPSRC Platform Grant (EP/M020517/1)the support from the Shanghai Pujiang Program (17PJ1406200)。
基金support from the National Science Foundation of China(61705032 and 61975025)the 111 project(B14039)the UESTC-ZTT joint laboratory project(H04W180463).
文摘The combination of optical fiber with graphene has greatly expanded the application regimes of fiber optics,from dynamic optical control and ultrafast pulse generation to high precision sensing.However,limited by fabrication,previous graphene-fiber samples are typically limited in the micrometer to centimeter scale,which cannot take the inherent advantage of optical fibers—longdistance optical transmission.Here,we demonstrate kilometers long graphene-coated optical fiber(GCF)based on industrial graphene nanosheets and coating technique.The GCF shows unusually high thermal diffusivity of 24.99 mm^(2) s^(-1) in the axial direction,measured by a thermal imager directly.This enables rapid thermooptical response both in optical fiber Bragg grating sensors at one point(18-fold faster than conventional fiber)and in long-distance distributed fiber sensing systems based on backward Rayleigh scattering in optical fiber(15-fold faster than conventional fiber).This work realizes the industrial-level graphene-fiber production and provides a novel platform for two-dimensional material-based optical fiber sensing applications.