Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of...Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L 4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were al eviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration fol owing sciatic nerve injury.展开更多
BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune comp...BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. Our experimental findings indicate that Brazil can regulate immune responses after nerve injury and promote sciatic nerve repair.展开更多
Background: Evidence on the relations of the American Heart Association’s ideal cardiovascular health (ICH) with mortality in Asians is sparse, and the interaction between behavioral and medical metrics remained uncl...Background: Evidence on the relations of the American Heart Association’s ideal cardiovascular health (ICH) with mortality in Asians is sparse, and the interaction between behavioral and medical metrics remained unclear. We aimed to fill the gaps. Methods: A total of 198,164 participants without cancer and cardiovascular disease (CVD) were included from the China Kadoorie Biobank study (2004-2018), Dongfeng-Tongji cohort (2008-2018), and Kailuan study (2006-2019). Four behaviors (i.e., smoking, physical activity, diet, body mass index) and three medical factors (i.e., blood pressure, blood glucose, and blood lipid) were classified into poor, intermediate, and ideal levels (0, 1, and 2 points), which constituted 8-point behavioral, 6-point medical, and 14-point ICH scores. Results of Cox regression from three cohorts were pooled using random-effects models of meta-analysis. Results: During about 2 million person-years, 20,176 deaths were recorded. After controlling for demographic characteristics and alcohol drinking, hazard ratios (95% confidence intervals) comparing ICH scores of 10-14 vs. 0-6 were 0.52 (0.41-0.67), 0.44 (0.37-0.53), 0.54 (0.45-0.66), and 0.86 (0.64-1.14) for all-cause, CVD, respiratory, and cancer mortality. A higher behavioral or medical score was independently associated with lower all-cause and CVD mortality among the total population and populations with different levels of behavioral or medical health equally, and no interaction was observed. Conclusions: ICH was associated with lower all-cause, CVD, and respiratory mortality among Chinese adults. Both behavioral and medical health should be improved to prevent premature deaths.展开更多
Insulators on high-voltage Uansmission lines are almost the only man-made structures on the Earth's surface intended for long-term operation under strong electric fields. After samples of natural contaminant parti...Insulators on high-voltage Uansmission lines are almost the only man-made structures on the Earth's surface intended for long-term operation under strong electric fields. After samples of natural contaminant particles were collected from insulator surfaces in China, it was found that the particle diameter distribution (PDD) was mainly concentrated in the 5-50 μm range. To analyze the statistical characteristics of these particles, this work studies the physical processes of particle collision and adhesion using the theories of hydrodynamics and collision dynamics. The physical model considers coupling of the fluid field and the electric field, introduces an adhesion criterion, and establishes a particle and surface collision model. The effects of relative humidity, wind speed, aerodynamic shape, electric field type, and electric field strength on particle adhesion were analyzed. The results show that the relative humidity and wind speed have very significant effects and the influences of the electric field type and the electric field strength are obvious, but the in fluence of the aerodynamic shape is relatively weak. The simulation results support the statistical characteristics determined in this work. The physical model established here provides reference values for study of the adhesion characteristics of particles on surfaces under electric fields.展开更多
Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid ...Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid hospital strain and ultimately reduce the risk of death from COVID-19.However,there is limited empirical evidence that hospital strain increases COVID-19 deaths.展开更多
What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematica...What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematically documented.What is added by this report?We summarized the characteristics of 74 imported COVID-19 outbreaks between March 19,2020 and December 31,2021.All outbreaks of early severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants were successfully contained with the aid of nucleic acid testing,modern communication technologies,and non-pharmacological interventions.What are the implications for public health practice?These findings provide us with confidence for the containment of future emerging infectious diseases alike at early stages to prevent pandemics or to win time to gain experience,develop vaccines and drugs,vaccinate people,and wait for the possible lessening of the virus’pathogenicity.展开更多
基金financially supported by the Science and Technology Bureau of Inner Mongolia Autonomous Region,No.Y2011024007
文摘Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L 4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were al eviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration fol owing sciatic nerve injury.
基金sponsored by Jilin Province Science and Technology Development Program,No.2009Z053
文摘BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. Our experimental findings indicate that Brazil can regulate immune responses after nerve injury and promote sciatic nerve repair.
基金supported by grants from the National Nature Science Foundation of China(Nos.81930124 and 82021005)The Dongfeng-Tongji cohort was supported by the National Key Research and Development Program of China(Nos.2016YFC0900801 and 2017YFC0907504)+2 种基金The China Kadoorie Biobank study was funded by the National Natural Science Foundation of China(Nos.82192901,82192900,and 81390540)the National Key Research and Development Program of China(No.2016YFC0900500)and the Chinese Ministry of Science and Technology(No.2011BAI09B01).
文摘Background: Evidence on the relations of the American Heart Association’s ideal cardiovascular health (ICH) with mortality in Asians is sparse, and the interaction between behavioral and medical metrics remained unclear. We aimed to fill the gaps. Methods: A total of 198,164 participants without cancer and cardiovascular disease (CVD) were included from the China Kadoorie Biobank study (2004-2018), Dongfeng-Tongji cohort (2008-2018), and Kailuan study (2006-2019). Four behaviors (i.e., smoking, physical activity, diet, body mass index) and three medical factors (i.e., blood pressure, blood glucose, and blood lipid) were classified into poor, intermediate, and ideal levels (0, 1, and 2 points), which constituted 8-point behavioral, 6-point medical, and 14-point ICH scores. Results of Cox regression from three cohorts were pooled using random-effects models of meta-analysis. Results: During about 2 million person-years, 20,176 deaths were recorded. After controlling for demographic characteristics and alcohol drinking, hazard ratios (95% confidence intervals) comparing ICH scores of 10-14 vs. 0-6 were 0.52 (0.41-0.67), 0.44 (0.37-0.53), 0.54 (0.45-0.66), and 0.86 (0.64-1.14) for all-cause, CVD, respiratory, and cancer mortality. A higher behavioral or medical score was independently associated with lower all-cause and CVD mortality among the total population and populations with different levels of behavioral or medical health equally, and no interaction was observed. Conclusions: ICH was associated with lower all-cause, CVD, and respiratory mortality among Chinese adults. Both behavioral and medical health should be improved to prevent premature deaths.
基金the Science-Technology Program of the State Grid Corporation of China (grant No. 521700140004)and the National Natural Science Foundation of China (grant No. 51777082)and the Fundamental Research Funds for the Central Universities (grant No. 2016YXZD069).
文摘Insulators on high-voltage Uansmission lines are almost the only man-made structures on the Earth's surface intended for long-term operation under strong electric fields. After samples of natural contaminant particles were collected from insulator surfaces in China, it was found that the particle diameter distribution (PDD) was mainly concentrated in the 5-50 μm range. To analyze the statistical characteristics of these particles, this work studies the physical processes of particle collision and adhesion using the theories of hydrodynamics and collision dynamics. The physical model considers coupling of the fluid field and the electric field, introduces an adhesion criterion, and establishes a particle and surface collision model. The effects of relative humidity, wind speed, aerodynamic shape, electric field type, and electric field strength on particle adhesion were analyzed. The results show that the relative humidity and wind speed have very significant effects and the influences of the electric field type and the electric field strength are obvious, but the in fluence of the aerodynamic shape is relatively weak. The simulation results support the statistical characteristics determined in this work. The physical model established here provides reference values for study of the adhesion characteristics of particles on surfaces under electric fields.
基金the Shenzhen Science and Technology Programs(JSGG20220301090202005,KQTD20190929172835662).
文摘Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid hospital strain and ultimately reduce the risk of death from COVID-19.However,there is limited empirical evidence that hospital strain increases COVID-19 deaths.
基金Supported by the Shenzhen Science and Technology Programs(RKX20210901150004012,KQTD20190929172835662,JSGG20220301090202005).
文摘What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematically documented.What is added by this report?We summarized the characteristics of 74 imported COVID-19 outbreaks between March 19,2020 and December 31,2021.All outbreaks of early severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants were successfully contained with the aid of nucleic acid testing,modern communication technologies,and non-pharmacological interventions.What are the implications for public health practice?These findings provide us with confidence for the containment of future emerging infectious diseases alike at early stages to prevent pandemics or to win time to gain experience,develop vaccines and drugs,vaccinate people,and wait for the possible lessening of the virus’pathogenicity.