Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with me...Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with medically unexplained symptoms.Based on the previous work,this review aims to comprehensively synthesise updated evidence related to SSD from recent years in English publications and,more extensively,from data published in Chinese language journals.The scoping review update was based on an earlier scoping review and included Chinese language publication data from China National Knowledge Internet(CNKI),WANFANG and WEIPU between January 2013 and May 2022 and data from PubMed,PsyclNFO,and Cochrane Library between June 2020 and May 2022.Initially,2984 articles were identified,of which 63 full texts were included for analysis.In China,SSD is mainly applied in scientific research,but it also shows good predictive validity and clinical application potential.The mean frequency of SSD was 4.5%in the general population,25.2%in the primary care population and 33.5%in diverse specialised care settings.Biological factors,such as brain region changes and heart rate variability,are associated with the onset of sSD.Psychological impairment related to somatic symptoms is the best predictor of prognosis.While adolescent SSD is significantly associated with family function,SSD overall is associated with an increased dysfunction of cognition and emotion,decreased quality of life,and high comorbidity with anxiety and depressive disorders.Further research is needed on suicide risk and cultural and gender-related issues.Updating the data of Chinese language studies,our research enriches the evidence-based findings related to the topics addressed in the text sections of the SSD chapter of DSM-5.However,research gaps remain about SSD reliability,population-based prevalence,suicide risk,and cultural and gender-related issues.展开更多
Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on...Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on chemical constituents and hypoglycemic activity of P.scabiosaefolia,4 lignan compounds,(+)-isolariciresinol(1),7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside(2),4-O-methylcedrusin(3)and patrinian A(4),were isolated and identifi ed.The hypoglycemic activity showed that compounds 2 and 3 could extremely signifi cantly improve insulin resistance at 100(P<0.001),50(P<0.001)and 25μmol/L(P<0.01)in IR 3T3-L1 cells.While compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100μmol/L(P<0.01).Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS,PI-3K,p-AKT and glucose transporter 4(GLUT4),and promoted the transcription of GLUT4 mRNA.Therefore,the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway.展开更多
文摘Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with medically unexplained symptoms.Based on the previous work,this review aims to comprehensively synthesise updated evidence related to SSD from recent years in English publications and,more extensively,from data published in Chinese language journals.The scoping review update was based on an earlier scoping review and included Chinese language publication data from China National Knowledge Internet(CNKI),WANFANG and WEIPU between January 2013 and May 2022 and data from PubMed,PsyclNFO,and Cochrane Library between June 2020 and May 2022.Initially,2984 articles were identified,of which 63 full texts were included for analysis.In China,SSD is mainly applied in scientific research,but it also shows good predictive validity and clinical application potential.The mean frequency of SSD was 4.5%in the general population,25.2%in the primary care population and 33.5%in diverse specialised care settings.Biological factors,such as brain region changes and heart rate variability,are associated with the onset of sSD.Psychological impairment related to somatic symptoms is the best predictor of prognosis.While adolescent SSD is significantly associated with family function,SSD overall is associated with an increased dysfunction of cognition and emotion,decreased quality of life,and high comorbidity with anxiety and depressive disorders.Further research is needed on suicide risk and cultural and gender-related issues.Updating the data of Chinese language studies,our research enriches the evidence-based findings related to the topics addressed in the text sections of the SSD chapter of DSM-5.However,research gaps remain about SSD reliability,population-based prevalence,suicide risk,and cultural and gender-related issues.
基金funded by National Key R&D Program of China(2022YFF1100300)National Natural Science Foundation of China(31900292)+1 种基金Science and Technology Development Program of Henan Province(212102110469,222102520035)Research on Precision Nutrition and Health Food,Department of Science and Technology of Henan Province(CXJD2021006).
文摘Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on chemical constituents and hypoglycemic activity of P.scabiosaefolia,4 lignan compounds,(+)-isolariciresinol(1),7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside(2),4-O-methylcedrusin(3)and patrinian A(4),were isolated and identifi ed.The hypoglycemic activity showed that compounds 2 and 3 could extremely signifi cantly improve insulin resistance at 100(P<0.001),50(P<0.001)and 25μmol/L(P<0.01)in IR 3T3-L1 cells.While compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100μmol/L(P<0.01).Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS,PI-3K,p-AKT and glucose transporter 4(GLUT4),and promoted the transcription of GLUT4 mRNA.Therefore,the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway.
