Regulated cell death(RCD)is a critical physiological process essential in maintaining skin homeostasis.Among the various forms of RCD,ferroptosis stands out due to its distinct features of iron accumulation,lipid pero...Regulated cell death(RCD)is a critical physiological process essential in maintaining skin homeostasis.Among the various forms of RCD,ferroptosis stands out due to its distinct features of iron accumulation,lipid peroxidation,and involvement of various inhibitory antioxidant systems.In recent years,an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders.Therefore,understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies.This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis,embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions,encompassing melanoma,psoriasis,systemic lupus erythematosus(SLE),vitiligo,and dermatological ailments precipitated by ultraviolet(UV)exposure,and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.82103183 to F.Z.,82102803,82272849 to G.D.)the Natural Science Foundation of Hunan Province(No.2022JJ40767 to F.Z.)+1 种基金the Natural Science Fund for Outstanding Youths in Hunan Province(No.2023JJ20093 to G.D.)the Huxiang Youth Talent Program(No.2023RC3072 to G.D.)
文摘Regulated cell death(RCD)is a critical physiological process essential in maintaining skin homeostasis.Among the various forms of RCD,ferroptosis stands out due to its distinct features of iron accumulation,lipid peroxidation,and involvement of various inhibitory antioxidant systems.In recent years,an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders.Therefore,understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies.This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis,embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions,encompassing melanoma,psoriasis,systemic lupus erythematosus(SLE),vitiligo,and dermatological ailments precipitated by ultraviolet(UV)exposure,and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.
