In this paper, Fe-doped TiO_2 photocatalyst supported on hollow glass microbeads(Fe-TiO_2 /beads)is prepared by dip-coating method, which uses hollow glass microbeads as the carriers and tetrabutylorthotitanate [Ti(O...In this paper, Fe-doped TiO_2 photocatalyst supported on hollow glass microbeads(Fe-TiO_2 /beads)is prepared by dip-coating method, which uses hollow glass microbeads as the carriers and tetrabutylorthotitanate [Ti(OC_4H_9)_4] as the raw material. The phase structure, ingredient, morphologies, particle size and shell thickness of the products are characterized by X-ray powder diffraction(XRD), energy-dispersive spectroscopy(EDS) and field emission scanning electron microscope(FESEM). The feasibility of photocatylic degradation of Rhodamine B(Rh B) under illumination of UV-vis light is studied. The results show that the core-shell structure catalyst is composed of Fe-doped anatase TiO_2 and hollow glass microbeads, and the catalytic activity of the TiO_2 is markedly enhanced by Fe ion doping. The optimum concentration of Fe ion is 0.1%(molecular fraction) in the precursor and the photocatalytic activity can be increased to 98% compared with that of the undoped one. The presence of ferrum elements neither influences the transformation of anatase to rutile, nor creates new crystal phases. The possible mechanism of photocatalytic oxidation is also discussed.展开更多
Summary What is already known about this topic?Vaccine effectiveness(VE)is positively correlated with the number of administered co-purified diphtheria,tetanus,and acellular pertussis vaccine(DTaP)doses.A matched case...Summary What is already known about this topic?Vaccine effectiveness(VE)is positively correlated with the number of administered co-purified diphtheria,tetanus,and acellular pertussis vaccine(DTaP)doses.A matched case-control study conducted in Zhongshan City revealed that the co-purified DTaP VE against pertussis-related illnesses in children aged 4–11 months was 42%for one dose,88%for two doses,and 95%for three doses,respectively.What is added by this report?The results of this study contribute to the current body of research.We found that the VE of co-purified DTaP against pertussis-related illness and hospitalization increased substantially,ranging from 24%–26%after one dose to 86%–87%after four doses.展开更多
Background:In the livestock industry,intramuscular fat content is a key factor affecting meat quality.Many studies have shown that dietary calcium supplementation is closely related to lipid metabolism.However,few stu...Background:In the livestock industry,intramuscular fat content is a key factor affecting meat quality.Many studies have shown that dietary calcium supplementation is closely related to lipid metabolism.However,few studies have examined the relationship between dietary calcium supplementation and intramuscular fat accumulation.Methods:Here,we used C2C12 cells,C57BL/6 mice(n=8)and three-way cross-breeding pigs(Duroc×Landrace×Large white)(n=10)to study the effect of calcium addition on intramuscular fat accumulation.In vitro,we used calcium chloride to adjust the calcium levels in the medium(2 mmol/L or 3 mmol/L).Then we measured various indicators.In vivo,calcium carbonate was used to regulate calcium levels in feeds(Mice:0.5%calcium or 1.2%calcium)(Pigs:0.9%calcium or 1.5%calcium).Then we tested the mice gastrocnemius muscle triglyceride content,pig longissimus dorsi muscle meat quality and lipidomics.Results:In vitro,calcium addition(3 mmol/L)had no significant effect on cell proliferation,but promoted the differentiation of C2C12 cells into slow-twitch fibers.Calcium supplementation increased triglyceride accumulation in C2C12 cells.Calcium addition increased the number of mitochondria and also increased the calcium level in the mitochondria and reduced the of key enzymes activity involved inβ-oxidation such as acyl-coenzyme A dehydrogenase.Decreasing mitochondrial calcium level can alleviate lipid accumulation induced by calcium addition.In addition,calcium addition also reduced the glycolytic capacity and glycolytic conversion rate of C2C12 cells.In vivo,dietary calcium supplementation(1.2%)promoted the accumulation of triglycerides in the gastrocnemius muscle of mice.Dietary calcium supplementation(1.5%)had no effect on pig weight,but significantly improved the flesh color of the longissimus dorsi muscle,reduced the backfat thickness and increased intramuscular fat content in pigs.Besides,calcium addition had no effect on longissimus dorsi pH,electrical conductivity and shear force.Conclusions:These results suggest that calcium addition promotes intramuscular fat accumulation by inhibiting the oxidation of fatty acids.These findings provide a new tool for increasing intramuscular fat content and an economical strategy for improving meat quality.展开更多
Acetylation of N^(4)-cytidine(ac^(4)C)has recently been discovered as a novel modification of mRNA.RNA ac^(4)C modification has been shown to be a key regulator of RNA stability,RNA translation,and the thermal stress ...Acetylation of N^(4)-cytidine(ac^(4)C)has recently been discovered as a novel modification of mRNA.RNA ac^(4)C modification has been shown to be a key regulator of RNA stability,RNA translation,and the thermal stress response.However,its existence in eukaryotic mRNAs is still controversial.In plants,the existence,distribution pattern,and potential function of RNA ac^(4)C modification are largely unknown.Here we report the presence of ac^(4)C in the mRNAs of both Arabidopsis thaliana and rice(Oryza sativa).By comparing two ac^(4)C sequencing methods,we found that RNA immunoprecipitation and sequencing(acRIP-seq),but not ac^(4)C sequencing,was suitable for plant RNA ac^(4)C sequencing.We present transcriptome-wide atlases of RNA ac^(4)C modification in A.thaliana and rice mRNAs obtained by acRIP-seq.Analysis of the distribution of RNA ac^(4)C modifications showed that ac^(4)C is enriched near translation start sites in rice mRNAs and near translation start sites and translation end sites in Arabidopsis mRNAs.The RNA ac^(4)C modification level is positively correlated with RNA half-life and the number of splicing variants.Similar to that in mammals,the translation efficiency of ac^(4)C target genes is significantly higher than that of other genes.Our in vitro translation results confirmed that RNA ac^(4)C modification enhances translation efficiency.We also found that RNA ac^(4)C modification is negatively correlated with RNA structure.These results suggest that ac^(4)C is a conserved mRNA modification in plants that contributes to RNA stability,splicing,translation,and secondary structure formation.展开更多
In late December 2019,clinicians in Hubei Province noticed and reported to health authorities a cluster of cases of pneumonia of unknown etiology(PUE)that turned out to be the start of the coronavirus disease 2019(COV...In late December 2019,clinicians in Hubei Province noticed and reported to health authorities a cluster of cases of pneumonia of unknown etiology(PUE)that turned out to be the start of the coronavirus disease 2019(COVID-19)pandemic(1).By January 29,2020,all provincial-level administrative divisions(PLADs)across the country had launched their highest public health emergency responses(Level 1 responses)(2-3).展开更多
Dielectric polarization performance induced by defect engineering approach has been proved to be an effective way for improving the microwave absorption property of carbon-based materials.Assisting by the solid-state ...Dielectric polarization performance induced by defect engineering approach has been proved to be an effective way for improving the microwave absorption property of carbon-based materials.Assisting by the solid-state reaction,the structural integrity of multi-walled carbon nanotubes(MWCNTs)would be broken along with the volume expansion and etching process of cobalt oxides.Therefore,the defects could be obtained and result in the enhancement of microwave absorption property.Ascribing to the broken wall structures,the defect-distances(L_(D))and concentrations(n_(D))have been optimized to be 9.80 nm and3.37×10^(11) cm^(-2).The minimum reflection loss(RL)had reached-54.6 dB at 4.5 GHz with a thickness of4.13 mm and the corresponding effective absorption bandwidth(EAB_(<-10 dB))was analyzed to be 14.6 GHz.Such enhancement is correlated to the dielectric polarization and the permeability-to-permittivity transformation raised from the defect structures and concentrations.The present work demonstrates an effective strategy for tailoring the microwave absorption property of MWCNTs by engineering defect concentrations,and could be further extended to other carbon-based absorbents.展开更多
Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divi...Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs.展开更多
Whereas hollow composites present some superiorities like abundant micro interfaces,outstanding impedance matching as the responses of electromagnetic wave(EMW),but versatile designs including crystal transformation,h...Whereas hollow composites present some superiorities like abundant micro interfaces,outstanding impedance matching as the responses of electromagnetic wave(EMW),but versatile designs including crystal transformation,heterogeneous structures and magnetic exchange coupling to further contribution are even not designed or stressed together in previous literatures.In this article,rational design on the hollow CoFe_(2)O_(4)/CoFe@C architecture has been conducted by a sequential process of self-sacrifice by combustion,in-suit polymerization and calcination.Results of morphology observation exhibit that heterogeneous CoFe_(2)O_(4)/CoFe@C composites were generated via crystal transformation from CoFe_(2)O_(4) to CoFe alloys with encapsulated carbon,together with ultimate growth of crystal particles.As for three carbon-based architectures,relatively low-graphitization carbon layers are favorable for enhancing impedance matching and polarization relaxation,but suppressing the conductive loss essentially.Moderate carbon content endows sample S2 with the maximum magnetic saturation(Ms)of 152.4 emu g^(-1).The optimized RL of sample S3 is up to-51 dB with 30 wt%loading,and the effective absorption band(EAB)is of 5.9 GHz at the thickness of 2.17 mm,while 6.0 GHz can be reached at 2.5 mm.Therefore,this hollow multi-interfaces design definitely shed light on novel structure for new excellent absorbers.展开更多
Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(...Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear.展开更多
Cerium oxide possesses intrinsic hydrophobic properties ascribed to the unique electronic structure.However,the relationship between the crystal structure and hydrophobicity of cerium oxide has not been systematically...Cerium oxide possesses intrinsic hydrophobic properties ascribed to the unique electronic structure.However,the relationship between the crystal structure and hydrophobicity of cerium oxide has not been systematically studied.Herein,it is experimentally and theoretically demonstrated that the water contact angle(105.9°)of the(111)surface is higher than that(91.7°)of the(220)surface,associated with the lower surface free energy(28.44 mN/m)of(111)surface than that(38.48 mN/m)of(220)surface.Furthermore,cerium oxide films with(111)-terminated surface are annealed at 300℃ and 600℃ for1 h,respectively.The lattice constant increases(5.4594Å<5.4613Å<5.4670Å)with decreasing the annealing temperature(600℃>300℃>the as-deposited),leading to the increased water contact angle(96.7°<96.8°<99.0°).The First-principles calculation provides microscopic insights into the wetting mechanism,originating from the weakened adsorption capacity of the(111)surface for water molecules with the increasing lattice constant.展开更多
文摘In this paper, Fe-doped TiO_2 photocatalyst supported on hollow glass microbeads(Fe-TiO_2 /beads)is prepared by dip-coating method, which uses hollow glass microbeads as the carriers and tetrabutylorthotitanate [Ti(OC_4H_9)_4] as the raw material. The phase structure, ingredient, morphologies, particle size and shell thickness of the products are characterized by X-ray powder diffraction(XRD), energy-dispersive spectroscopy(EDS) and field emission scanning electron microscope(FESEM). The feasibility of photocatylic degradation of Rhodamine B(Rh B) under illumination of UV-vis light is studied. The results show that the core-shell structure catalyst is composed of Fe-doped anatase TiO_2 and hollow glass microbeads, and the catalytic activity of the TiO_2 is markedly enhanced by Fe ion doping. The optimum concentration of Fe ion is 0.1%(molecular fraction) in the precursor and the photocatalytic activity can be increased to 98% compared with that of the undoped one. The presence of ferrum elements neither influences the transformation of anatase to rutile, nor creates new crystal phases. The possible mechanism of photocatalytic oxidation is also discussed.
基金Supported by the Joint Foundation of Beijing Natural Science Foundation and Haidian Original Innovation(L202037)as well as the Chinese Center for Disease Control and Prevention's Operation of Public Health Emergency Response Mechanism(131031001000200001).
文摘Summary What is already known about this topic?Vaccine effectiveness(VE)is positively correlated with the number of administered co-purified diphtheria,tetanus,and acellular pertussis vaccine(DTaP)doses.A matched case-control study conducted in Zhongshan City revealed that the co-purified DTaP VE against pertussis-related illnesses in children aged 4–11 months was 42%for one dose,88%for two doses,and 95%for three doses,respectively.What is added by this report?The results of this study contribute to the current body of research.We found that the VE of co-purified DTaP against pertussis-related illness and hospitalization increased substantially,ranging from 24%–26%after one dose to 86%–87%after four doses.
基金supported by the grants from National Key R&D Program of China (2018YFD0500402)Guangxi Science Foundation for Distinguished Young Scholars (2020GXNSFFA297008)+4 种基金Guangxi Science and Technology Base and Talents Project (AD18281085)Guangxi Natural Science Foundation(2019GXNSFDA245029)Guangxi Hundred-Talent ProgramState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(SKLCUSA-a202006)Training Project of High-level Professional and Technical Talents of Guangxi University。
文摘Background:In the livestock industry,intramuscular fat content is a key factor affecting meat quality.Many studies have shown that dietary calcium supplementation is closely related to lipid metabolism.However,few studies have examined the relationship between dietary calcium supplementation and intramuscular fat accumulation.Methods:Here,we used C2C12 cells,C57BL/6 mice(n=8)and three-way cross-breeding pigs(Duroc×Landrace×Large white)(n=10)to study the effect of calcium addition on intramuscular fat accumulation.In vitro,we used calcium chloride to adjust the calcium levels in the medium(2 mmol/L or 3 mmol/L).Then we measured various indicators.In vivo,calcium carbonate was used to regulate calcium levels in feeds(Mice:0.5%calcium or 1.2%calcium)(Pigs:0.9%calcium or 1.5%calcium).Then we tested the mice gastrocnemius muscle triglyceride content,pig longissimus dorsi muscle meat quality and lipidomics.Results:In vitro,calcium addition(3 mmol/L)had no significant effect on cell proliferation,but promoted the differentiation of C2C12 cells into slow-twitch fibers.Calcium supplementation increased triglyceride accumulation in C2C12 cells.Calcium addition increased the number of mitochondria and also increased the calcium level in the mitochondria and reduced the of key enzymes activity involved inβ-oxidation such as acyl-coenzyme A dehydrogenase.Decreasing mitochondrial calcium level can alleviate lipid accumulation induced by calcium addition.In addition,calcium addition also reduced the glycolytic capacity and glycolytic conversion rate of C2C12 cells.In vivo,dietary calcium supplementation(1.2%)promoted the accumulation of triglycerides in the gastrocnemius muscle of mice.Dietary calcium supplementation(1.5%)had no effect on pig weight,but significantly improved the flesh color of the longissimus dorsi muscle,reduced the backfat thickness and increased intramuscular fat content in pigs.Besides,calcium addition had no effect on longissimus dorsi pH,electrical conductivity and shear force.Conclusions:These results suggest that calcium addition promotes intramuscular fat accumulation by inhibiting the oxidation of fatty acids.These findings provide a new tool for increasing intramuscular fat content and an economical strategy for improving meat quality.
基金support from the National Natural Science Foundation of China(32070613,32270623)the Science and Technology Innovation Program of Hunan Province(2021RC3045)+1 种基金support from the National Natural Science Foundation of China(U20A2029)support from the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20200468).
文摘Acetylation of N^(4)-cytidine(ac^(4)C)has recently been discovered as a novel modification of mRNA.RNA ac^(4)C modification has been shown to be a key regulator of RNA stability,RNA translation,and the thermal stress response.However,its existence in eukaryotic mRNAs is still controversial.In plants,the existence,distribution pattern,and potential function of RNA ac^(4)C modification are largely unknown.Here we report the presence of ac^(4)C in the mRNAs of both Arabidopsis thaliana and rice(Oryza sativa).By comparing two ac^(4)C sequencing methods,we found that RNA immunoprecipitation and sequencing(acRIP-seq),but not ac^(4)C sequencing,was suitable for plant RNA ac^(4)C sequencing.We present transcriptome-wide atlases of RNA ac^(4)C modification in A.thaliana and rice mRNAs obtained by acRIP-seq.Analysis of the distribution of RNA ac^(4)C modifications showed that ac^(4)C is enriched near translation start sites in rice mRNAs and near translation start sites and translation end sites in Arabidopsis mRNAs.The RNA ac^(4)C modification level is positively correlated with RNA half-life and the number of splicing variants.Similar to that in mammals,the translation efficiency of ac^(4)C target genes is significantly higher than that of other genes.Our in vitro translation results confirmed that RNA ac^(4)C modification enhances translation efficiency.We also found that RNA ac^(4)C modification is negatively correlated with RNA structure.These results suggest that ac^(4)C is a conserved mRNA modification in plants that contributes to RNA stability,splicing,translation,and secondary structure formation.
文摘In late December 2019,clinicians in Hubei Province noticed and reported to health authorities a cluster of cases of pneumonia of unknown etiology(PUE)that turned out to be the start of the coronavirus disease 2019(COVID-19)pandemic(1).By January 29,2020,all provincial-level administrative divisions(PLADs)across the country had launched their highest public health emergency responses(Level 1 responses)(2-3).
基金the National Natural Science Foundation of China(U1704253 and U1908220)the Zhejiang Provincial Natural Science Foundation of China(LR18E010001)+2 种基金the National Key Research and Development Program of China(2019YFE0121700)the LiaoNing Revitalization Talents Program(XLYC1807177)the Fundamental Research Funds for the Central Universities(N2102010)。
文摘Dielectric polarization performance induced by defect engineering approach has been proved to be an effective way for improving the microwave absorption property of carbon-based materials.Assisting by the solid-state reaction,the structural integrity of multi-walled carbon nanotubes(MWCNTs)would be broken along with the volume expansion and etching process of cobalt oxides.Therefore,the defects could be obtained and result in the enhancement of microwave absorption property.Ascribing to the broken wall structures,the defect-distances(L_(D))and concentrations(n_(D))have been optimized to be 9.80 nm and3.37×10^(11) cm^(-2).The minimum reflection loss(RL)had reached-54.6 dB at 4.5 GHz with a thickness of4.13 mm and the corresponding effective absorption bandwidth(EAB_(<-10 dB))was analyzed to be 14.6 GHz.Such enhancement is correlated to the dielectric polarization and the permeability-to-permittivity transformation raised from the defect structures and concentrations.The present work demonstrates an effective strategy for tailoring the microwave absorption property of MWCNTs by engineering defect concentrations,and could be further extended to other carbon-based absorbents.
基金funded by grants from the Vaccine Preventable Diseases and Immunization(VDI)of World Health Organization Office in China(No.2020/1017283-0).
文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs.
基金This work was supported by the National Natural Science Foundation of China(No.51622106)the Liao Ning Revitalization Talents Program(No.XLYC1807076)。
文摘Whereas hollow composites present some superiorities like abundant micro interfaces,outstanding impedance matching as the responses of electromagnetic wave(EMW),but versatile designs including crystal transformation,heterogeneous structures and magnetic exchange coupling to further contribution are even not designed or stressed together in previous literatures.In this article,rational design on the hollow CoFe_(2)O_(4)/CoFe@C architecture has been conducted by a sequential process of self-sacrifice by combustion,in-suit polymerization and calcination.Results of morphology observation exhibit that heterogeneous CoFe_(2)O_(4)/CoFe@C composites were generated via crystal transformation from CoFe_(2)O_(4) to CoFe alloys with encapsulated carbon,together with ultimate growth of crystal particles.As for three carbon-based architectures,relatively low-graphitization carbon layers are favorable for enhancing impedance matching and polarization relaxation,but suppressing the conductive loss essentially.Moderate carbon content endows sample S2 with the maximum magnetic saturation(Ms)of 152.4 emu g^(-1).The optimized RL of sample S3 is up to-51 dB with 30 wt%loading,and the effective absorption band(EAB)is of 5.9 GHz at the thickness of 2.17 mm,while 6.0 GHz can be reached at 2.5 mm.Therefore,this hollow multi-interfaces design definitely shed light on novel structure for new excellent absorbers.
基金supported by the National Natural Science Foundation of China(32070739,31771528,and 91754107)Zhejiang Provincial Natural Science Foundation of China(LR21C070001)+3 种基金the National Basic Research Program of China(2017YFA0503402)to C.YiNatural Science Foundation for Young Scientists of China(81800085)Natural Science Foundation of Hubei Province,China(ZRMS2020002147)to J.TongZhejiang Key R&D Program of China(2019C02030)to L.Zhang。
文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear.
基金supported by the National Natural Science Foundation of China(U1704253,U1908220)the Fundamental Research Funds for the Central Universities(N160208001,N180206001)+2 种基金the Zhejiang Provincial Natural Science Foundation(LR18E010001)the National 1000-Plan for Young Scholarsthe Start-Up Funding Supported from the Northeastern University of China。
基金financially supported by the National Natural Science Foundation of China(Nos.51901062 and U1908220)the Natural Science Foundation of Zhejiang Province(No.LR18E010001)+1 种基金the Key R&D Project of Zhejiang Province(Nos.2019C01121 and 2021C01023)the LiaoNing Revitalization Talents Program(No.XLYC1807177)。
文摘Cerium oxide possesses intrinsic hydrophobic properties ascribed to the unique electronic structure.However,the relationship between the crystal structure and hydrophobicity of cerium oxide has not been systematically studied.Herein,it is experimentally and theoretically demonstrated that the water contact angle(105.9°)of the(111)surface is higher than that(91.7°)of the(220)surface,associated with the lower surface free energy(28.44 mN/m)of(111)surface than that(38.48 mN/m)of(220)surface.Furthermore,cerium oxide films with(111)-terminated surface are annealed at 300℃ and 600℃ for1 h,respectively.The lattice constant increases(5.4594Å<5.4613Å<5.4670Å)with decreasing the annealing temperature(600℃>300℃>the as-deposited),leading to the increased water contact angle(96.7°<96.8°<99.0°).The First-principles calculation provides microscopic insights into the wetting mechanism,originating from the weakened adsorption capacity of the(111)surface for water molecules with the increasing lattice constant.