Improvement of integrated battlefield situational awareness in complex environments involving dynamic factors such as restricted communications and electromagnetic interference(EMI)has become a contentious research pr...Improvement of integrated battlefield situational awareness in complex environments involving dynamic factors such as restricted communications and electromagnetic interference(EMI)has become a contentious research problem.In certain mission environments,due to the impact of many interference sources on real-time communication or mission requirements such as the need to implement communication regulations,the mission stages are represented as a dynamic combination of several communication-available and communication-unavailable stages.Furthermore,the data interaction between unmanned aerial vehicles(UAVs)can only be performed in specific communication-available stages.Traditional cooperative search algorithms cannot handle such situations well.To solve this problem,this study constructed a distributed model predictive control(DMPC)architecture for a collaborative control of UAVs and used the Voronoi diagram generation method to re-plan the search areas of all UAVs in real time to avoid repetition of search areas and UAV collisions while improving the search efficiency and safety factor.An attention mechanism ant-colony optimization(AACO)algorithm is proposed for UAV search-control decision planning.The search strategy is adaptively updated by introducing an attention mechanism for regular instruction information,a priori information,and emergent information of the mission to satisfy different search expectations to the maximum extent.Simulation results show that the proposed algorithm achieves better search performance than traditional algorithms in restricted communication constraint scenarios.展开更多
To the Editor:Diabetic kidney disease(DKD)has become the leading cause of end-stage kidney disease(ESKD).According to the Kidney Disease Improving Global Outcomes(KDIGO)guidelines,rapid kidney function decline in DKD ...To the Editor:Diabetic kidney disease(DKD)has become the leading cause of end-stage kidney disease(ESKD).According to the Kidney Disease Improving Global Outcomes(KDIGO)guidelines,rapid kidney function decline in DKD is defined as an estimated glomerular filtration rate(eGFR)slope≤−5 mL∙min^(−1)∙1.73 m^(−2)·year^(−1).The prognoses of patients who experience rapid eGFR decline are usually poor.In a multicenter retrospective study,230 of 377(61%)biopsy-proven DKD patients were rapid decliners.[1]It was reported that 32%and 42%of 195 type 2 diabetes(T2D)Pima Indians with normoalbuminuria and microalbuminuria,respectively,had a rapid eGFR decline,indicating that proteinuria alone has difficulty in fully predicting rapid kidney function decline in DKD patients with T2D.[2]Therefore,it is of interest to identify more useful clinicopathological predictors of a rapid kidney function decline in T2D patients.展开更多
High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of porphyria.Based on the advantages of longer luminescence lifetime and lower background interference,organic a...High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of porphyria.Based on the advantages of longer luminescence lifetime and lower background interference,organic afterglow molecular porphyrin detection probes were developed,but these probes show poor water solubility and insufficient luminescence intensity.Herein,we present an afterglow nanoprobe(Eu-NP)for porphyria detection in whole blood.The luminescent substance(europium complex)and the organic vinyl co mpound reacted with singlet oxygen(^(1)O_(2))were selected for encapsulation in polystyrene spheres.Eu-NP can respond to^(1)O_(2)produced by porphyrins,and the detection signals can be obtained by the emission of the afterglow Eu^(3+)-emissive nanosensor.Eu-NP can achieve high-sensitivity detection of porphyrin,and the lowest detection limit reaches 0.29μmol/L.The porphyrin detection in whole blood samples is consistent with clinical diagnosis results.Compared with the organic afterglow molecule,the Eu-NPs constructed in this work show a higher signal-to-noise ratio and sensitivity of porphyria detection.展开更多
基金the support of the National Natural Science Foundation of China(Grant No.62076204)the Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University(Grant No.CX2020019)in part by the China Postdoctoral Science Foundation(Grants No.2021M700337)。
文摘Improvement of integrated battlefield situational awareness in complex environments involving dynamic factors such as restricted communications and electromagnetic interference(EMI)has become a contentious research problem.In certain mission environments,due to the impact of many interference sources on real-time communication or mission requirements such as the need to implement communication regulations,the mission stages are represented as a dynamic combination of several communication-available and communication-unavailable stages.Furthermore,the data interaction between unmanned aerial vehicles(UAVs)can only be performed in specific communication-available stages.Traditional cooperative search algorithms cannot handle such situations well.To solve this problem,this study constructed a distributed model predictive control(DMPC)architecture for a collaborative control of UAVs and used the Voronoi diagram generation method to re-plan the search areas of all UAVs in real time to avoid repetition of search areas and UAV collisions while improving the search efficiency and safety factor.An attention mechanism ant-colony optimization(AACO)algorithm is proposed for UAV search-control decision planning.The search strategy is adaptively updated by introducing an attention mechanism for regular instruction information,a priori information,and emergent information of the mission to satisfy different search expectations to the maximum extent.Simulation results show that the proposed algorithm achieves better search performance than traditional algorithms in restricted communication constraint scenarios.
基金National Natural Science Fund(Nos.82070748,82090020,and 82090021)National Key Research and Development Program(Nos.2022YFC2502500 and 2022YFC2502502)China International Medical Foundation Renal Anemia Fund,and grants from National High-Level Hospital Clinical Research Funding(Nos.2022SF01 and 2022XW01)
文摘To the Editor:Diabetic kidney disease(DKD)has become the leading cause of end-stage kidney disease(ESKD).According to the Kidney Disease Improving Global Outcomes(KDIGO)guidelines,rapid kidney function decline in DKD is defined as an estimated glomerular filtration rate(eGFR)slope≤−5 mL∙min^(−1)∙1.73 m^(−2)·year^(−1).The prognoses of patients who experience rapid eGFR decline are usually poor.In a multicenter retrospective study,230 of 377(61%)biopsy-proven DKD patients were rapid decliners.[1]It was reported that 32%and 42%of 195 type 2 diabetes(T2D)Pima Indians with normoalbuminuria and microalbuminuria,respectively,had a rapid eGFR decline,indicating that proteinuria alone has difficulty in fully predicting rapid kidney function decline in DKD patients with T2D.[2]Therefore,it is of interest to identify more useful clinicopathological predictors of a rapid kidney function decline in T2D patients.
基金Project supported by the National Key R&D Program of China(2017YFA0205100)the National Natural Science Foundation of china(2193700321874027)。
文摘High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of porphyria.Based on the advantages of longer luminescence lifetime and lower background interference,organic afterglow molecular porphyrin detection probes were developed,but these probes show poor water solubility and insufficient luminescence intensity.Herein,we present an afterglow nanoprobe(Eu-NP)for porphyria detection in whole blood.The luminescent substance(europium complex)and the organic vinyl co mpound reacted with singlet oxygen(^(1)O_(2))were selected for encapsulation in polystyrene spheres.Eu-NP can respond to^(1)O_(2)produced by porphyrins,and the detection signals can be obtained by the emission of the afterglow Eu^(3+)-emissive nanosensor.Eu-NP can achieve high-sensitivity detection of porphyrin,and the lowest detection limit reaches 0.29μmol/L.The porphyrin detection in whole blood samples is consistent with clinical diagnosis results.Compared with the organic afterglow molecule,the Eu-NPs constructed in this work show a higher signal-to-noise ratio and sensitivity of porphyria detection.
