A facile and efficient route to 4-aryl-2-[2-（trifluoromethylthio） aryl]quinazoline derivatives through a tandem directed Rh-catalyzed C-H iodination and trifluoromethylthiolation is described. The reaction proceeded...A facile and efficient route to 4-aryl-2-[2-（trifluoromethylthio） aryl]quinazoline derivatives through a tandem directed Rh-catalyzed C-H iodination and trifluoromethylthiolation is described. The reaction proceeded under mild reaction conditions, exhibited good functional group tolerance with a broad scope of substrate and excellent regi- oselectivity in good to excellent yields.展开更多
An efficient synthetic method for bis（indol-3-yl）alkane derivatives has been developed.In the presence of 5 mol%of pyridinium tribromide（PTB）,the condensation of indoles and aldehydes proceeded smoothly under mild...An efficient synthetic method for bis（indol-3-yl）alkane derivatives has been developed.In the presence of 5 mol%of pyridinium tribromide（PTB）,the condensation of indoles and aldehydes proceeded smoothly under mild conditions,giving rise to the corresponding bis（indol-3-yl）alkanes in good to excellent yields.展开更多
基金Financial support from National Natural Science Foundation of China （Nos. 21162012 and 21362014） and Key Laboratory of Functional Small Organic Mol-ecule, Ministry of Education, Jiangxi Normal University （No. KLFS-KF-201407） is gratefully acknowledged.
文摘A facile and efficient route to 4-aryl-2-[2-（trifluoromethylthio） aryl]quinazoline derivatives through a tandem directed Rh-catalyzed C-H iodination and trifluoromethylthiolation is described. The reaction proceeded under mild reaction conditions, exhibited good functional group tolerance with a broad scope of substrate and excellent regi- oselectivity in good to excellent yields.
基金the National Natural Science Foundation of China(Nos.20862009 and 20962010)the National Natural Science Foundation of Jiangxi Province(No.2008GQH0026)the Science Foundation of Education Department of Jiangxi Province(No.GJJ10386) for their financial support
文摘An efficient synthetic method for bis（indol-3-yl）alkane derivatives has been developed.In the presence of 5 mol%of pyridinium tribromide（PTB）,the condensation of indoles and aldehydes proceeded smoothly under mild conditions,giving rise to the corresponding bis（indol-3-yl）alkanes in good to excellent yields.
