Cognitive J^(2)SAC:Joint Jamming,Sensing,and Communication Under Antagonistic Environment

Integrated sensing and communication(ISAC)is regarded as a recent advanced technology,which is expected to realize the dual functions of sensing and communication simultaneously in one system.Nevertheless,it still faces the challenges of the information security and transmission robustness caused by the openness of wireless channel,especially under antagonistic environment.Hence,this article develops a generalized framework,named cognitive joint jamming,sensing and communication(cognitive J2SAC),to empower the current sensing/communication/jamming system with a“brain”for realizing precise sensing,reliable communication and effective jamming under antagonistic environment.Three kinds of gains can be captured by cognitive J2SAC,including integrated gain,cooperative gain and cognitive gain.Moreover,we highlight the enabling mechanism among jamming,sensing,and communication,as well as illustrating several typical use cases of cognitive J2SAC.Furthermore,several key enabled technologies are analyzed and a typical sensing enhance integrated communication and jamming case study is discussed to verify the effectiveness of the proposed method.Last but not the least,the future directions are listed before concluding this article.Integrated sensing and communication(ISAC)is regarded as a recent advanced technology,which is expected to realize the dual functions of sensing and communication simultaneously in one system.Nevertheless,it still faces the challenges of the information security and transmission robustness caused by the openness of wireless channel,especially under antagonistic environment.Hence,this article develops a generalized framework,named cognitive joint jamming,sensing and communication(cognitive J2SAC),to empower the current sensing/communication/jamming system with a“brain”for realizing precise sensing,reliable communication and effective jamming under antagonistic environment.Three kinds of gains can be captured by cognitive J2SAC,including integrated gain,cooperative gain and cognitive gain.Moreover,we highlight the enabling mechanism among jamming,sensing,and communication,as well as illustrating several typical use cases of cognitive J2SAC.Furthermore,several key enabled technologies are analyzed and a typical sensing enhance integrated communication and jamming case study is discussed to verify the effectiveness of the proposed method.Last but not the least,the future directions are listed before concluding this article.

Targeting human MutT homolog 1(MTH1) for cancer eradication:current progress and perspectives

Since accelerated metabolism produces much higher levels of reactive oxygen species(ROS)in cancer cells compared to ROS levels found in normal cells,human MutT homolog 1(MTH1),which sanitizes oxidized nucleotide pools,was recently demonstrated to be crucial for the survival of cancer cells,but not required for the proliferation of normal cells.Therefore,dozens of MTH1 inhibitors have been developed with the aim of suppressing cancer growth by accumulating oxidative damage in cancer cells.While several inhibitors were indeed confirmed to be effective,some inhibitors failed to kill cancer cells,complicating MTH1 as a viable target for cancer eradication.In this review,we summarize the current status of developing MTH1 inhibitors as drug candidates,classify the MTH1 inhibitors based on their structures,and offer our perspectives toward the therapeutic potential against cancer through the targeting of MTH1.