Emerging viral infections are a growing threat to human health and often have originated from zoonotic diseases[1].Viruses infecting animals can cross the interspecies barrier and infect humans by the evolution of gen...Emerging viral infections are a growing threat to human health and often have originated from zoonotic diseases[1].Viruses infecting animals can cross the interspecies barrier and infect humans by the evolution of genetic variants with more fit replication in mammals,which has been defined as“genetic tuning”[2].All the influenza A virus subtypes have been isolated fromwild birds.Influenza A viruses cross the avian-human species barrier by acquiring genetic mutations or reassortments that enable them to adapt to humans[3].Several avian influenza viruses(AIVs)(e.g.,H5N1,H7N7,H9N2,H7N9,H5N6 and H7N4)can infect humans and cause respiratory diseases with a range of severity[4].展开更多
基金supported by JST-CREST,Japan(Grant Number JPMJCR15F4)the JST-MIRAI Program,Japan(Grant Number JPMJMI19D4)+1 种基金partly by a Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology(MEXT)of Japan(Grant Numbers 18K15171,19H04841,20K21723,20KK0224)partly by grants from the Takeda Science Foundation,the Ichiro Kanehara Foundation,SENSHIN Medical Research Foundation,and a Sasakawa Scientific Research Grant from the Japan Science Society.
文摘Emerging viral infections are a growing threat to human health and often have originated from zoonotic diseases[1].Viruses infecting animals can cross the interspecies barrier and infect humans by the evolution of genetic variants with more fit replication in mammals,which has been defined as“genetic tuning”[2].All the influenza A virus subtypes have been isolated fromwild birds.Influenza A viruses cross the avian-human species barrier by acquiring genetic mutations or reassortments that enable them to adapt to humans[3].Several avian influenza viruses(AIVs)(e.g.,H5N1,H7N7,H9N2,H7N9,H5N6 and H7N4)can infect humans and cause respiratory diseases with a range of severity[4].
