Association between Diabetes Mellitus and Oral Health Status in Japanese Adults

Aim The objective of this study was to analyze the oral health among Japanese adults, with and without diabetes mellitus. Methodology The subjects were 518 community residents aged 20 to 91 years in Japan, who participated in the ＂Akita health and nutrition survey＂ and the ＂Akita dental disease survey＂, conducted in 2006. The surveys comprised a self-administered questionnaire, along with medical and dental examinations. Results Using the community periodontal index （CPI）, the mean numbers of sextants presenting codes 0, 1 and 2 were significantly lower in diabetics than non-diabetics among the 59 years or younger age group. Although the mean numbers of sextants with codes 0, 1 and 2 among the 60 to 69 years age group were lower, and sextants with a code X among the 59 years or younger age group were higher in diabetics than non-diabetics, no statistically significant differences were detected. The tendency of lower mean numbers of natural teeth and functional tooth units in diabetics than non-diabetics was observed, however no differences were statistically significant. Conclusion The outcome of periodontal disease seemed to be influenced by the diabetic state to some degree, but a clear association between diabetes and oral health status was not found.

苯二氮革类对尾加压素Ⅱ诱发大鼠大脑皮层切片去甲上腺素释放的影响

背景尾加压素Ⅱ（Urotensin-Ⅱ，UⅡ）及其受体（UT）与精神状态、情绪失调有关（如紧张和焦虑），其作用部分与大脑皮层去甲肾上腺素释放增加有关。苯二氮革类药物产生催眠和抗焦虑作用，减少大脑皮层去甲肾上腺素的释放。因此，我们假设苯二氮革类和UⅡ在大脑皮层存在一定的相互作用。方法本研究中，我们检测苯二氮革类对大鼠大脑皮层切片UⅡ诱发去甲肾上腺素释放的影响以及对大鼠含UT受体的HEK293细胞内（HEK293-rUTcells）Ca2＋（[Ca2＋]i）浓度的影响。结果咪达唑仑、地西泮和氟硝西泮均可浓度依赖地抑制UⅡ诱发去甲肾上腺素的释放，但对[Ca2＋]i浓度无影响。咪达唑仑抑制UⅡ诱发的去甲肾上腺素释放的IC50（0．32CM，P〈0．01），显著低于地西泮（187μM）和氟硝西泮（40μM）。咪达唑仑对UⅡ诱发的去甲肾上腺素释放的抑制作可被苯二氮革类的拮抗剂氟马西尼显著减弱。结论目前研究表明，临床剂量下的咪达唑仑可以显著抑制UII诱发的去甲肾上腺素释放。这种抑制作用，部分地受中枢苯二氮革类受体的调节。