Injury to central nervous system （CNS） tissues in adult mam- mals often leads to neuronal loss, scarring, and permanently lost neurologic functions, and this default healing response is increasingly linked to a pro-...Injury to central nervous system （CNS） tissues in adult mam- mals often leads to neuronal loss, scarring, and permanently lost neurologic functions, and this default healing response is increasingly linked to a pro-inflammatory innate immune response. Extracellular matrix （ECM） technology can reduce inflammation, while increasing functional tissue remodeling in various tissues and organs, including the CNS.展开更多
After central nervous system（CNS）injury,a pro-inflammatory,innate immune response contributes to permanently lost neuronal function by promoting changes in the micro-environment and extracellular matrix（ECM）that l...After central nervous system（CNS）injury,a pro-inflammatory,innate immune response contributes to permanently lost neuronal function by promoting changes in the micro-environment and extracellular matrix（ECM）that lead to CNS neuronal degeneration and death and permanent scarring.展开更多
文摘Injury to central nervous system （CNS） tissues in adult mam- mals often leads to neuronal loss, scarring, and permanently lost neurologic functions, and this default healing response is increasingly linked to a pro-inflammatory innate immune response. Extracellular matrix （ECM） technology can reduce inflammation, while increasing functional tissue remodeling in various tissues and organs, including the CNS.
基金funding from the Department of Defense office of the Congressionally Directed Medical Research Programs and the Clinical and Rehabilitative Medicine Research Program (MBS,MR130444)Competitive Medical Research Fund,University of Pittsburgh (MBS),Pennsylvania Lions Sight Conservation & Eye Research Foundation (MBS),Sterling Lions Club of Pennsylvania and Dance for Sight (MBS),Start-up funds,Department of Ophthalmology,University of Pittsburgh (MBS)+1 种基金National Institutes of Health CORE Grant P30 EY008098Eye and Ear Foundation of Pittsburgh,PA,Unrestricted Grant from Research to Prevent Blindness,New York,NY
文摘After central nervous system（CNS）injury,a pro-inflammatory,innate immune response contributes to permanently lost neuronal function by promoting changes in the micro-environment and extracellular matrix（ECM）that lead to CNS neuronal degeneration and death and permanent scarring.
