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Design, synthesis and molecular docking studies of novel triazole antifungal compounds 被引量:1
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作者 Qiu Qin He Ke Li +4 位作者 yong bing cao Huan Wen Dong Li Hua Zhao Chao Mei Liu Chun Quan Sheng 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第6期663-666,共4页
Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal ac... Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi. 展开更多
关键词 Lanosterol 14α-demethylase TRIAZOLE TERT-BUTYL Antifungal activity Fluconazole-resistant
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