太赫兹金属光子晶体结构研究

鉴于金属光子晶体结构在滤波、极化、传感、成像等领域的重要作用,研究了基于三角形晶格的金属光子晶体的超常透射、光子能带和表面波特性。采用三维时域有限差分法对金属光子晶体结构建模,同时解释超常透射机理;推导和讨论光子能带沿着ΓK和ΓM晶格方向的能带图,分析不同的表面波特征,并解释非对称入射下观察到的三角形的两个晶格方向模式分裂效应;建立了描述这种模式分裂效应的精确的表面模式谐振频率公式,并对金属光子晶体的色散进行了定量分析。研究结果可为太赫兹功能器件的研究提供参考。

泥石流防治工程损毁度评价——以汶川地区为例

泥石流岩土防治工程被广泛应用于泥石流灾害的治理,而工程的损毁程度会对工程的功能性产生一定的影响,并影响效益的持续发挥。文章以汶川为研究区域,选取18条泥石流沟的岩土防治工程作为研究对象,结合现场考察,对防治工程的损毁程度进行评价。评价指标体系总体上分为拦挡工程因子和排导工程因子2项,细化二级评价指标包括坝基损毁度、坝肩损毁度、坝体损毁度、基础冲刷度、结构冲击度、斜坡推力度等6项。运用模糊综合评价方法构建判断矩阵和隶属度函数,将损毁度等级划分为优、良、中、差四个等级。评价结果显示,除板子沟和登溪沟的防治工程损毁等级为差和中以外,其余泥石流沟内防治工程损毁等级均为良或优,且评价结果与现场考察一致。

车体称重调簧试验台视觉定位控制系统研究

基于中南大学研制的车体称重调簧试验台硬件设计,摒弃了硬件改动较大的基于位移传感器的闭环控制方案,而是利用现有资源及机器视觉技术代替人眼完成定位控制操作。围绕前端图像采集、图像识别及特征提取、后端半闭环反馈控制3部分搭建基于图像信息的手眼视觉伺服系统模型,提出基于Open CV机器视觉库的参数自适应改进Hough变换算法识别目标特征轮廓,应用TMS320C6748系列嵌入式DSP图像处理平台,提供一套多路视频信号分时定位控制的通用解决方案。根据实测结果,本视觉定位控制系统可以准确识别试验所需3种不同车型的二系簧定位销形状,并且系统的定位控制精度在±2 mm以内,满足系统定位精度要求的±5 mm,相比手动方式缩短定位补偿时间75%,提高试验台自动化程度和试验效率。

计及源荷相关性含电动汽车的分布式电源选址定容规划

分布式电源大规模并入电网与电动汽车的广泛应用在优化能源结构的同时,也给配电网的选址定容规划带来新的挑战。本文通过拉丁超立方抽样并结合Cholesky分解和Nataf变换,得到具有相关性的风速、光照强度与需求负荷样本;利用蒙特卡洛模拟得到具有随机性的电动汽车充电负荷,与考虑不确定因素的风光荷样本相结合,由K-means聚类方法进行场景聚类得到典型的运行场景;利用机会约束规划方法建立规划模型,并以收缩因子粒子群优化算法求解;通过典型IEEE 33节点算例分析了风光荷相关性与电动汽车不同充电方式对规划方案的影响。结果表明:电动汽车用户选择常规充电方式能够降低电网负荷;考虑风力、光伏与负荷之间的相关性,得到的规划方案将更经济且更具有指导意义。

Oral microbiota in human systematic diseases

Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the human body and the environment.The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling,hosts, and external environmental factors. These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria, and the destruction of the microbial community is related to systemic diseases. In this review, we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases. This review aims to enhance the interest to oral microbes on the whole human body, and also improve clinician’s understanding of the role of oral microbes in systemic diseases. Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases,and at the same time, continuous advances in this frontier field may lead to a tangible impact on human health.

Massive pulmonary haemorrhage due to severe trauma treated with repeated alveolar lavage combined with extracorporeal membrane oxygenation:A case report

BACKGROUND Massive pulmonary haemorrhage can spoil the entire lung and block the airway in a short period of time due to severe bleeding,which quickly leads to death.Alveolar lavage is an effective method for haemostasis and airway maintenance.However,patients often cannot tolerate alveolar lavage due to severe hypoxia.We used extracorporeal membrane oxygenation(ECMO)to overcome this limitation in a patient with massive pulmonary haemorrhage due to severe trauma and succeeded in saving the life by repeated alveolar lavage.CASE SUMMARY A 22-year-old man sustained multiple injuries in a motor vehicle accident and was transferred to our emergency department.On admission,he had a slight cough and a small amount of bloody sputum;computed tomography revealed multiple fractures and mild pulmonary contusion.At 37 h after admission,he developed severe chest tightness,chest pain,dizziness and haemoptysis.His oxygen saturation was 68%.Emergency endotracheal intubation was performed,and a large amount of bloody sputum was suctioned.After transfer to the intensive care unit,he developed refractory hypoxemia and heparin-free venovenous ECMO was initiated.Fibreoptic bronchoscopy revealed diffuse and profuse blood in all bronchopulmonary segment.Bleeding was observed in the trachea and right bronchus,and repeated alveolar lavage was performed.On day 3,the patient’s haemoptysis ceased,and ECMO support was terminated 10 d later.Tracheostomy was performed on day 15,and the patient was weaned from the ventilator on day 21.CONCLUSION Alveolar lavage combined with ECMO can control bleeding in trauma-induced massive pulmonary haemorrhage,is safe and can be performed bedside.

Early Detection of Myelodysplastic Syndrome/Leukemia-associated Mutations Using NGS Is Critical in Treating Aplastic Anemia

Distinguishing between aplastic anemia(AA)and hypoblastic myelodysplastic syndrome(hMDS)with a low percentage of bone marrow(BM)blasts(<5%)can be difficult due to the overlap in clonality and a spectrum of genetic alternations between the two subtypes of diseases.However,due to recent advances in DNA sequencing technology,both spectnim and frequency of mutations can be accurately determined and monitored by next-generation sequencing(NGS)at initial diagnosis and during immunosuppressive therapy(1ST)in patients with AA or hMDS.This improvement in acquiring a patient's genetic status and clonal evolution can provide more proper,precise,and on-time information to guide disease management,which is especially helpful in the absence of traditional morphologic/cytogenetic evidence.

Susceptibility assessment of debris flows using the analytic hierarchy process method——A case study in Subao river valley, China

Many debris flows have occurred in the areas surrounding the epicenter of the Wenchuan earthquake. Susceptibility assessment of debris flows in this area is especially important for disaster prevention and mitigation. This paper studies one of the worst hit areas, the Subao river valley, and the susceptibility assessment of debris flows is performed based on field surveys and remote sensing interpretation. By investigating the formation conditions of debris flows in the valley, the following assessment factors are selected： mixture density of landslides and rock avalanches, distance to the seismogenic fault, stratum lithology, ground roughness, and hillside angle. The weights of the assessment factors are determined by the analytic hierarchy process （AHP） method. Each of the assessment factors is further divided into five grades. Then, the assessment model is built using the multifactor superposition method to assess the debris flow susceptibility. Based on the assessment results, the Subao river valley is divided into three areas： high susceptibility areas, medium susceptibility areas, and low susceptibility areas. The high susceptibility areas are concentrated in the middle of the valley, accounting for 17.6%of the valley area. The medium susceptibility areas are in the middle and lower reaches, most of which are located on both sides of the high susceptibility areas and account for 45.3% of the valley area. The remainders are clas-sified as low susceptibility areas. The results of the model are in accordance with the actual debris flow events that occurred after the earthquake in the valley, confirming that the proposed model is capable of assessing the debris flow susceptibility. The results can also provide guidance for reconstruction planning and debris flow prevention in the Subao river valley.

Experimental Study on the Cyclic Ampacity and Its Factor of 10 kV XLPE Cable

The load varies periodically, but the peak current of power cable is controlled by its continuous ampacity in China, resulting in the highest conductor temperature is much lower than90℃, the permitted long-term working temperature of XLPE. If the cable load is controlled by its cyclic ampacity, the cable transmission capacity could be used sufficiently. To study the 10 kV XLPE cable cyclic ampacity and its factor, a three-core cable cyclic ampacity calculation software is developed and the cyclic ampacity experiments of direct buried cable are undertaken in this paper. Experiments and research shows that the software calculation is correct and the circuit numbers and daily load factor have an important impact on the cyclic ampacity factor. The cyclic ampacity factor of 0.7 daily load factor is 1.20, which means the peak current is the 1.2 times of continuous ampacity. If the continuous ampacity is instead by the cyclic ampacity to control the cable load, the transmission capacity of the cable can be improved greatly without additional investment.

Ruxolitinib add-on in corticosteroid-refractory graft-vs-host disease after allogeneic stem cell transplantation:Results from a retrospective study on 38 Chinese patients

BACKGROUND Graft-vs-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell transplantation.Some patients have steroid-refractory(SR) GVHD.AIM To evaluate the effect and safety of ruxolitinib add-on in the treatment of patients with SR acute (a) and chronic (c) GVHD.METHODS We retrospectively analyzed 38 patients administered ruxolitinib add-on to standard immunosuppressive therapy for SR-aGVHD or SR-cGVHD following allogeneic hematopoietic stem cell transplantation.Ruxolitinib was administered5-10 mg/d depending on disease severity,patient status,and the use of antifungal drugs.Overall response rate,time to best response,malignancy relapse rate,infection rate,and treatment-related adverse events were assessed.RESULTS The analysis included 10 patients with SR-aGVHD (gradeⅢ/Ⅳ,n=9) and 28patients with SR-cGVHD (moderate/severe,n=24).For the SR-aGVHD and SRcGVHD groups,respectively:Median number of previous GVHD therapies was 2(range:1-3) and 2 (1-4);median follow-up was 2.5 (1.5-4) and 5 (1.5-10) mo;median time to best response was 1 (0.5-2.5) and 3 (1-9.5) mo;and overall response rate was 100%(complete response:80%) and 82.1%(complete response:10.7%) with a response observed in all GVHD-affected organs.The malignancy relapse rates for the SR-aGVHD and SR-cGVHD groups were 10.0%and 10.7%,respectively.Reactivation rates for cytomegalovirus,Epstein-Barr virus,and varicella-zoster virus,respectively,were 30.0%,10.0%,and 0%for the SR-aGVHD group and 0%,14.3%,and 7.1%for the SR-cGVHD group.CONCLUSION Ruxolitinib add-on was effective and safe as salvage therapy for SR-GVHD.

Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy

Discontinuation of tyrosine kinase inhibitor(TKI)therapy after achieving a persistent deep molecular response(DMR)is an urgently needed treatment goal for chronic myeloid leukemia(CML)patients and has been included in the National Comprehensive Cancer Network(NCCN)guidelines(version 2.2017)for CML.Indeed,various studies have confirmed the feasibility of discontinuing TKI therapy.In this study,we analyzed data from 45 CML patients who had discontinued TKI therapy.Univariate analysis was performed to predict factors that were potentially related to treatment-free remission(TFR)and identify the differences between early relapse and late relapse.Out of the 45 patients,20 exhibited molecular relapse after a median follow-up of 18 months(range,1-54 months),and the estimated TFR at 24 months was 40%.The univariate analysis revealed that a high Sokal score and interruptions or dose reductions during TKI treatment were the only baseline factors associated with poor outcomes.Our results indicate that TKI discontinuation could be successfully put into practice in China.

AIC AR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity

Although the advent of tyrosine kinase inhibitors(TKIs)has dramatically improved the survival of patients with chronic myeloid leukaemia(CML),acquired drug resistance and TKI-insensitive leukaemic stem cells(LSCs)remain major obstacles to a CML cure.In recent years,the reprogramming of mitochondrial metabolism has emerged as a hallmark of cancers,including CML,and in turn may be exploited for therapeutic purposes.Here,we investigated the effects of several drugs on the mitochondrial function of the CML cell line K562 and found that 5-aminoimidazole-4-carboxamide ribotide(AICAR)and decitabine could effectively increase the ATP content and mitochondrial biogenesis.In addition,these two drugs induced cell cycle arrest and a decrease in colony-forming capacity and promoted K562 cell differentiation.Moreover,we demonstrated that treatment with AICAR or decitabine enhanced the sensitivity o f K562 cells to imatinib,as evidenced by a combination treatment assay.Altogether,our findings indicate that TKIs combined with mitochondrial regulation may provide a therapeutic strategy for the treatment of CML.

Multi-body dynamics modeling and test of an articulated steering half-track tractor

With the benefits of small turning radius and high trafficability, the articulated steering half-track tractor had been widely utilized in orchard and small spaced farmland. To study the dynamic performance of the articulated steering half-track tractor and provide a model basis for studying the path tracking control, an accurate multi-body dynamic model of the tractor was required. In this study, the crucial parameters in the dynamic model construction of the tractor were investigated. Firstly, the topology model of the components of the half-track tractor was built by RecurDyn, in which the movement subs and driver functions were given. Secondly, considering the difference of dynamic characteristic of the articulated steering tractor with respect to different pavement hardnesses, the soft and hard pavement models were constructed by employing the harmonic superposition method. Finally, the simulations of the half-track tractor under straight-line and swerve had been conducted on the two types of pavements, and the simulation results were compared with the experimental and theoretical results. The results indicated that the average speed error of the dynamic model on hard pavement and farmland soft pavement were 2.7% and 2.1% compared with the real tractor tests. At the same time, the straight-line driving offset errors of the dynamic model on the two pavements were 1.6% and 3.8% for the front wheels and the rear wheels offset errors were 3.9% and 2.4%, respectively. Furthermore, the turning radius error under front wheel steering was 8.2% and the error under articulated steering was 5.3%. It is proved that the established dynamic model had high accuracy, which provides an efficient approach to analyze the dynamic features of the half-track tractor.

PEN/BADCy Interlayer Dielectric Films with Tunable Microstructures via an Assist of Temperature for Enhanced Frequency Stability

Low dielectric in terlayer films have become an important element to ensure the development of the microelectr onics industry.A kind of flexible interlayer dielectrics,polyarylene ether nitrile/bisphenol A cyanate ester(PEN/BADCy)film,with good thermal stability and low frequency dependence,has been developed by solution casting method.Herein,materials were designed to incorporate bisphenol A cyanate ester as a part of blend,contributing to the frequency stability and structural integrity.The morphological study combined with electron microscopy revealed the uniform and flexible microstructure information with controllable morphology through self-polymerization of cyanate esters with different prepolymerization time and curing temperatures.The dielectric films could present high thermal stability with Tg>180℃.Significant improvement in the dielectric properties was achieved for the dielectric constant and loss was much stabler than neat PEN over the frequency range from 100 Hz to 5 MHz.When the prepolymerization time was 3h and final curing temperature reached 230℃,the dielectric constant and dielectric loss of the films were 3.36 and 0.013 at 100 kHz,respectively.The dimensional stability(CTE=53.67×10^-6 K^-1)was confirmed and con sidered beneficial to use as an in terlayer dielectrics.

临床病例讨论 第496例——反复晕厥8年

患者女, 25岁, 因反复晕厥8年, 再发2个月就诊于海南医学院第二附属医院神经内科。患者以反复晕厥起病, 近1年感双下肢乏力、易疲劳, 近3个月感腰部及四肢关节疼痛, 双上肢掌指关节活动度增大, 皮肤弹性增加。卧立位经颅多普勒超声(TCD)示卧位平均心率79 次/min;立位平均心率126 次/min;卧立位血压正常;大脑中动脉卧位平均脑血流速度62 cm/s;立位平均脑血流速度47 cm/s。基因检测提示LDB3基因突变。最终诊断:体位性心动过速综合征(关节过度活动型), Ehlers-Danlos综合征, 予以补液、康复治疗后好转。

DBU-catalyzed dearomative annulation of 2-pyridylacetates withα,β-unsaturated pyrazolamides for the synthesis of multisubstituted 2,3-dihydro-4H-quinolizin-4-ones

The reaction of 2-pyridylacetates andα,β-unsaturated pyrazolamides with DBU as the catalyst has been developed.A range of unexplored multisubstituted 2,3-dihydro-4H-quinolizin-4-ones are obtained with satisfactory yields(up to 94%)and excellent diastereoselectivities(all cases>20:1 dr)via a dearomative[3+3]annulation process.This practical method also features transition metal free,mild reaction conditions,wide functional group tolerance,easy scale-up synthesis,and versatile further derivatization.