Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

Golden-flower fungus,the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea,is considered a potential probiotic fungus based on its anti-obesity effect.However,the classification of golden-flower fungi is still controversial;the anti-obesity effect of golden-flower fungus polysaccharides remains unknown.In this study,we identify a golden-flower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis,which resolves the controversy of classification.Moreover,we find A.cristatus polysaccharides(ACPS)attenuate obesity in rats.ACPS modulate gut bacterial composition.in which Akkermansia,Akkermansia muciniphila,Bacteroides,Romboutsia,Blautia,and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum,hepatic,and fecal total bile acid content.Furthermore,ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity,according to a fecal transplantation experiment.Thus,ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.

Multi-Blockchain Based Data Trading Markets With Novel Pricing Mechanisms

In the era of big data,there is an urgent need to establish data trading markets for effectively releasing the tremendous value of the drastically explosive data.Data security and data pricing,however,are still widely regarded as major challenges in this respect,which motivate this research on the novel multi-blockchain based framework for data trading markets and their associated pricing mechanisms.In this context,data recording and trading are conducted separately within two separate blockchains:the data blockchain(DChain) and the value blockchain(VChain).This enables the establishment of two-layer data trading markets to manage initial data trading in the primary market and subsequent data resales in the secondary market.Moreover,pricing mechanisms are then proposed to protect these markets against strategic trading behaviors and balance the payoffs of both suppliers and users.Specifically,in regular data trading on VChain-S2D,two auction models are employed according to the demand scale,for dealing with users’ strategic bidding.The incentive-compatible Vickrey-Clarke-Groves(VCG)model is deployed to the low-demand trading scenario,while the nearly incentive-compatible monopolistic price(MP) model is utilized for the high-demand trading scenario.With temporary data trading on VChain-D2S,a reverse auction mechanism namely two-stage obscure selection(TSOS) is designed to regulate both suppliers’ quoting and users’ valuation strategies.Furthermore,experiments are carried out to demonstrate the strength of this research in enhancing data security and trading efficiency.

The accumulation characteristics and exploration potential of oil and gas in the back-arc basin of Japan under the background of high heat flow

The Sea of Japan is located in the southeast margin of Eurasia, in the triangle area of the western Pacific Ocean. Due to the interaction of the Pacific plate, Eurasian plate and Philippine plate, its tectonic environment is complex, forming a typical trench-arc-basin system. At present, 148 oil and gas fields have been discovered in Japan, with an oil and gas resource of 255.78×10^(6) t, showing a good prospect for oil and gas exploration. Based on the previous research and the recently collected geological and geophysical data, the characteristics of tectonic-sedimentary evolution and geothermal field in the basins around the Sea of Japan are analyzed. The results show that the tectonic evolution of the basin is mainly controlled by plate subduction and back-arc oceanic crust expansion, and it mainly undergone four tectonic-sedimentary evolution stages: Subduction period, basin development period, subsidence period and compression deformation period. The overall heat flow value of Japan Sea is high, and it is distributed annularly along Yamato Ridge. The geothermal heat flow value is about 50–130 MW/m^(2), and the average heat flow is75.9±19.8 MW/m^(2), which has a typical “hot basin ”. The high heat flow background provides unique thermal evolution conditions for hydrocarbon generation, which leads to the high temperature and rapid evolution. The authors summarized as “early hydrocarbon generation, rapid maturity and shallow and narrow hydrocarbon generation window”. The type of oil and gas is mainly natural gas, and it mainly distributed in Neogene oil and gas reservoirs. The trap types are mainly structural traps, lithologic traps and composite traps. In addition, the pre-Neogene bedrock oil and gas reservoirs also show a good exploration prospect. The resource prospecting indicates that Niigata Basin, Ulleung Basin and kitakami Basin are the main target areas for future exploration and development.

Organic geochemical characteristics and significance of Permian Gufeng formation siliceous shale in well CSDP-2 of South Yellow Sea central uplift

In order to understand the hydrocarbon generation potential of the siliceous shale in the Permian Gufeng Formation of the South Yellow Sea,the organic geochemistry and organic petrology of the siliceous shale in the Gufeng Formation of the CSDP-2 well were studied and analyzed.It is found that the TOC of the samples is mainly between 9%and 12%,and Tmaxis mainly distributed between 510 and 540℃.The value of the organic microscopic type index(TI)is between 25.71 and 31.00,which is a set of II_(2)high-quality source rocks with high organic matter abundance in the over mature stage of largescale gas generation.According to the distribution characteristics of Molecular fossils in siliceous shale of Gufeng Formation of well CSDP-2,bacterial organic matter is the main hydrocarbon generating parent material,and aquatic animal organic matter is an important hydrocarbon generating parent material.The siliceous shale in Gufeng Formation of CSDP-2 well is in the stage of large-scale gas generation;Therefore,the Gufeng Formation in the central uplift of the South Yellow Sea has the material basis for the formation of large-scale shale gas reservoirs.At the same time,the siliceous metasomatism of the siliceous shale reservoir of Gufeng Formation is not conducive to the primary migration of oil,and there is much oil and gas remaining in the reservoir.

ACP-based social computing and parallel intelligence： Societies 5.0 and beyond

Social computing, as the technical foundation of future computational smart societies, has the potential to improve the effectiveness of opensource big data usage, systematically integrate a variety of elements including time, human, resources, scenarios, and organizations in the current cyber-physical-social world, and establish a novel social structure with fair information, equal rights, and a flat configuration. Meanwhile, considering the big modeling gap between the model world and the physical world, the concept of parallel intelligence is introduced. With the help of software-defined everything, parallel intelligence bridges the big modeling gap by means of constructing artificial systems where computational experiments can be implemented to verify social policies, economic strategies, and even military operations. Artificial systems play the role of ＂social laboratories＂ in which decisions are computed before they are executed in our physical society. Afterwards, decisions with the expected outputs are executed in parallel in both the artificial and physical systems to interactively sense, compute, evaluate and adjust system behaviors in real-time, leading system behaviors in the physical system converging to those proven to be optimal in the artificial ones. Thus, the smart guidance and management for our society can be achieved.

三层博弈视角下推进中国对欧直接投资的机遇与路径

2017年以来,欧盟及其成员国逐步加大外资审查力度且对中国指向性明显提高。在中欧投资博弈关系中,欧盟成员国都不是单方面的博弈方:一方面,需遵守欧盟规章条例,欧盟因素在其与中国博弈时影响较大;另一方面,德国等核心成员国也可以通过对欧盟理事会等施加影响,进而与中国在国际层面进行磋商。整体上,欧盟外资政策趋严大方向不会改变,但三层博弈视角下中资入欧仍有机遇,中国进一步提高对外开放也会增加博弈中的赢集。为此,推进中国对欧直接投资的策略和路径包括:国家层面,完善外资法律基础并深化中欧投资合作,加快推进《中欧全面投资协定》的签署和实施;企业层面,依据自身特点做好投资前期准备和风险评估,应对可能导致交易失败的因素和问题提前做好防范。

Epidemiology and natural history of hepatitis C virus infection

Hepatitis C virus(HCV)affects 130-210 million people worldwide and is one of the major risk factors for hepatocellular carcinoma.Globally,at least one third of hepatocellular carcinoma cases are attributed to HCV infection,and 350000 people died from HCV related diseases per year.There is a great geographical variation of HCV infection globally,with risk factors for the HCV infection differing in various countries.The progression of chronic hepatitis C to end-stage liver disease also varies in different study populations.A long-term follow-up cohort enrolling participants with asymptomatic HCV infection is essential for elucidating the natural history of HCV-caused hepatocellular carcinoma,and for exploring potential seromarkers that have high predictability for risk of hepatocellular carcinoma.However,prospective cohorts comprising individuals with HCV infection are still uncommon.The risk evaluation of viral load elevation and associated liver disease/cancer in HCV(REVEAL-HCV)study has followed a cohort of 1095 residents seropositive for antibodies against hepatitis C virus living in seven townships in Taiwan for more than fifteen years.Most of them have acquired HCV infection through iatrogenic transmission routes.As the participants in the REVEALHCV study rarely receive antiviral therapies,it provides a unique opportunity to study the natural history of chronic HCV infection.In this review,the prevalence,risk factors and natural history of HCV infection are comprehensively reviewed.The study cohort,data collection,and findings on liver disease progression of the REVEAL-HCV study are described.

Prospective prediction and exploration situation of marine Mesozoic-Paleozoic oil and gas in the South Yellow Sea

The South Yellow Sea Basin is a large sedimentary basin superimposed by the Mesozoic-Paleozoic marine sedimentary basin and the Mesozoic-Cenozoic terrestrial sedimentary basin, where no oil and gas fields have been discovered after exploration for 58 years. After the failure of oil and gas exploration in terrestrial basins, the exploration target of the South Yellow Sea Basin turned to the marine Mesozoic- Paleozoic strata. After more than ten years' investigation and research, a lot of achievements have been obtained. The latest exploration obtained effective seismic reflection data of deep marine facies by the application of seismic exploration technology characterized by high coverage, abundant low-frequency components and strong energy source for the deep South Yellow Sea Basin. In addition, some wells drilled the Middle-Upper Paleozoic strata, with obvious oil and gas shows discovered in some horizons. The recent petroleum geological research on the South Yellow Sea Basin shows that the structure zoning of the marine residual basin has been redetermined, the basin structure has been defined, and 3 seismic reflection marker layers are traceable and correlatable in the residual thick Middle-Paleozoic strata below the continental Meso-Cenozoic strata in the South Yellow Sea Basin. Based on these, the seismic sequence of the marine sedimentary strata was established. According to the avaliable oil and gas exploration and research, the marine Mesozoic-Paleozoic oil and gas prospects of the South Yellow Sea were predicted as follows.(1) The South Yellow Sea Basin has the same sedimentary formation and evolution history during the sedimentary period of the Middle-Paleozoic marine basin with the Sichuan Basin.(2) There are 3 regional high-quality source rocks.(3) The carbonate and clastic reservoirs are developed in the Mesozoic- Paleozoic strata.(4) The three source-reservoir-cap assemblages are relatively intact.(5) The Laoshan Uplift is a prospect area for the Lower Paleozoic oil and gas, and the Wunansha Uplift is one for the marine Upper Paleozoic oil and gas.(6) The Gaoshi stable zone in the Laoshan Uplift is a favorable zone.(7) The marine Mesozoic-Paleozoic strata in the South Yellow Sea Basin has the geological conditions required to form large oil and gas fields, with remarkable oil and gas resources prospect. An urgent problem to be addressed now within the South Yellow Sea Basin is to drill parametric wells for the Lower Paleozoic strata as the target, to establish the complete stratigraphic sequence since the Paleozoic period, to obtain resource evaluation parameters, and to realize the strategic discovery and achieve breakthrough in oil and gas exploration understanding.

Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy:A systematic review and meta-analysis

AIM: To evaluate the benefit and safety of sivelestat(a neutrophil elastase inhibitor) administration in patients undergoing esophagectomy. METHODS: Online databases including Pub Med, EMBASE, the Cochrane Library, Web of Knowledge, and Chinese databases(Wanfang database, VIP and CNKI) were searched systematically up to November 2013. Randomized controlled trials and high-qualitycomparative studies were considered eligible for inclusion. Three reviewers evaluated the methodological quality of the included studies, and Stata 12.0 software was used to analyze the extracted data. The risk ratio(RR) was used to express the effect size of dichotomous outcomes, and mean difference(MD) or standardized mean difference was used to express the effect size of continuous outcomes.RESULTS: Thirteen studies were included in this systematic review and nine studies were included in the meta-analysis. The duration of mechanical ventilation was significantly decreased in the sivelestat group on postoperative day 5 [I2 = 76.3%, SMD =-1.41, 95%CI:-2.63-(-0.19)]. Sivelestat greatly lowered the incidence of acute lung injury in patients after surgery(I2 = 0%, RR = 0.27, 95%CI: 0.08-0.93). However, it did not decrease the incidence of pneumonia, intensive care unit stay or postoperative hospital stay, and did not increase the incidence of complications such as anastomotic leakage, recurrent nerve palsy, wound infection, sepsis and catheter-related fever. CONCLUSION: A neutrophil elastase inhibitor is beneficial in patients undergoing esophagectomy. More high quality, large sample, multi-center and randomized controlled trials are needed to validate this effect.

Sedimentological sequence and depositional evolutionary model of Lower Triassic carbonate rocks in the South Yellow Sea Basin

Based on well logging and seismic data, combined with a comparative analysis of drilling data in the Lower Yangtze region, the sequence stratigraphic framework of the Qinglong Formation was established and divided into four third-order sequences. Each sequence is mainly composed of the transgress system tract (TST) and the high-stand system tract (HST). According to the lithology, logging curve and seismic reflection structure, the sedimentary filling characteristics and evolution law for the sequence are analyzed. The results show that each sequence is dominated by a half-cycle decline of sea level, and the rise-fall of sea level controls the distribution and evolution of sedimentary systems within the sequence. During the relative sea-level rise, sedimentation rates slow down and muddy sediments are developed. The characteristics of condensing intervals on the flooding surface are very obvious, and continental shelf and open platform deposition are mainly developed. During the relative decline of sea level, the thickness of sediments increased. The main developments were restricted platform and platform shoal environment, and locally developed evaporation platform environment.

Where Does AlphaGo Go: From Church-Turing Thesis to AlphaGo Thesis and Beyond

An investigation on the impact and significance of the AlphaGo vs. Lee Sedol Go match is conducted, and concludes with a conjecture of the AlphaGo Thesis and its extension in accordance with the Church-Turing Thesis in the history of computing. It is postulated that the architecture and method utilized by the AlphaGo program provide an engineering solution for tackling issues in complexity and intelligence. Specifically, the AlphaGo Thesis implies that any effective procedure for hard decision problems such as NP-hard can be implemented with AlphaGo-like approach. Deep rule-based networks are proposed in attempt to establish an understandable structure for deep neural networks in deep learning. The success of AlphaGo and corresponding thesis ensure the technical soundness of the parallel intelligence approach for intelligent control and management of complex systems and knowledge automation. © 2014 Chinese Association of Automation.

Monte Carlo simulation for performance evaluation of detector model with a monolithic LaBr_(3)(Ce)crystal and SiPM array forγradiation imaging

In recent years,LaBr_(3)(Ce)crystals and silicon photomultipliers(SiPMs)have been increasingly used in radiation imaging.This study involved the establishment of a detector model with a monolithic LaBr_(3)(Ce)crystal and SiPM array forγ-radiation imaging on the GEANT4 platform.The optical process included in the detector model was defined by key parameters,such as the emission spectrum,scintillation yield,and intrinsic resolution of the LaBr_(3):5%Ce crystal,as well as the detection efficiency of the SiPM array.The response of the detector model to^(57)Co flooded field irradiation was simulated and evaluated.The radiation images generated by the detector model exhibited a compression effect that was very close to that on images acquired by the physical detector.The spatial resolution of the simulated detector closely approximates that of the physical experiment.A detector model without the optical process was also established for comparison with a detector using the optical process.Both were used in a near-field modified uniform redundant array(MURA)imaging system to acquire images of a point source and a ring source of^(57)Co at the center of the field-of-view of the imaging system.The spatial resolution and signal-to-noise ratio of the images that were reconstructed using the two detector models were determined and compared.Compared with the detector model without optical processes,although the images from the proposed detector model have slightly inferior signal-to-noise ratios and more artifacts,they are more consistent with the reconstructed versions of images acquired in real physical experiments.The results confirm that the detector model can be used to design aγ-radiation imaging detector and to develop an imaging algorithm that can significantly shorten the development time and reduce the cost.

Social Manufacturing for High-end Apparel Customization

Social manufacturing(SM), a novel distributed,collaborative and intelligent manufacturing mode, is proposed and developed for high-end apparel customization. The main components of SM cloud are designed, and its research topics are summarized. Then, SM's key technologies are studied. 3D technologies for apparel customization, like 3D modeling, 3D fitting mirror and 3D customization, are developed to improve the customization precision and user experience. Information based collaborative management is realized to share, communicate,and handle the information efficiently among all groups and individuals of SM cloud. Suppliers' evaluation mechanism is designed to support the optimal decisions making. Next, SM cloud is constructed in five layers for high-end apparel customization.By using SM cloud based crowd-sourcing, social resources can be allocated rationally and utilized efficiently, consumer can customize the product in any processes like innovation, design,making, marketing and service, and traditional apparel enterprise can be upgraded into SM mode for keeping it competitive in the future customization markets.

State-of-the-Art Technology in the Construction of Sea-Crossing Fixed Links with a Bridge, Island, and Tunnel Combination

In general, two kinds of structures are used to provide a way across a river, canal, sea, or other obstacle: bridge structures that pass over the obstacle, and tunnel structures that pass below the obstacle. Although the construction of both bridges and tunnels can be traced back over thousands of years, bridge–tunnel combinations that use an island as a sea-crossing fixed link (SCFL) have only been built over the past 82 years. The first such combination was probably the 6.4 km long San Francisco–Oakland Bay Bridge in the United States, which was completed in 1936. The most recently constructed SCFL combining a bridge, tunnel, and island is the Hong Kong–Zhuhai–Macao (HZM) Bridge, which opened for traffic on October 24, 2018 with the longest SCFL combination in the world, at a total length of 29.6 km.

Extracorporeal Membrane Oxygenation Support in Resuscitations for Acute Myocardial Infarction with Cardiac Arrest

MORTALITY rate of acute myocardial infarction (AMI) patients could be as high as 80％,if present with or develop fatal arrhythmia and cardiac arrest.Some patients,despite the treatment with inotropes and intra-aortic balloon pump,are not hemodynamically stable enough to undergo emergent revascularization.The use of extracorporeal membrane oxygenation (ECMO) can help stabilize circulation and respiration,which could be a potential solution for patients under such critical circumstances.In this paper,we describe the application of ECMO for the resuscitations of 4 cardiac arrested AMI cases.

Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma

BACKGROUND The impact of body mass index(BMI)on survival in patients with esophageal squamous cell carcinoma(ESCC)undergoing surgery remains unclear.Therefore,a definition of clinically significant BMI in patients with ESCC is needed.AIM To explore the impact of preoperative weight loss(PWL)-adjusted BMI on overall survival(OS)in patients undergoing surgery for ESCC.METHODS This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011.The relationship between PWL-adjusted BMI and OS was examined,and a multivariate analysis was performed and adjusted for age,sex,TNM stage and adjuvant therapy.RESULTS Trends of poor survival were observed for patients with increasing PWL and decreasing BMI.Patients with BMI≥20.0 kg/m2 and PWL<8.8%were classified into Group 1 with the longest median OS(45.3 mo).Patients with BMI<20.0 kg/m2 and PWL<8.8%were classified into Group 2 with a median OS of 29.5 mo.Patients with BMI≥20.0 kg/m2 and PWL≥8.8%(HR=1.9,95%CI:1.5-2.5),were combined into Group 3 with a median OS of 20.1 mo.Patients in the three groups were associated with significantly different OS(P<0.05).In multivariate analysis,PWL-adjusted BMI,TNM stage and adjuvant therapy were identified as independent prognostic factors.CONCLUSION PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery.BMI might be an indicator for patients with PWL<8.8%rather than≥8.8%.

Research on the "three shells" cooperative support technology of large-section chambers in deep mines

The"three shells"cooperative support technology was proposed herein according to both the large deformation of the rock surrounding large-section chambers in deep mines and the precarious stability of the support structures therein.The development range of the plastic zone in the surrounding rock was controlled by a stress shell to reduce the difficulty of controlling the surrounding rock.Additionally,the residual strength of the rock mass in the plastic zone and the self-bearing capacity of the surrounding rock were improved by a reinforced load-bearing shell.Furthermore,a passive load-bearing shell could restore the triaxial stress state of the surrounding rock on the free surface,reduce the influence of the external environment on the surrounding rock,and reinforce the surrounding rock with the strength of the shell.Reasonable layouts of large-section chambers were determined by analyzing the control effect of the stress shell on the surrounding rock under three kinds of in situ stress fields.The orthogonal test method was applied to reveal the influences of different support parameters in the reinforced loadbearing shell and passive load-bearing shell on the surrounding rock stability.The surrounding rock control effect of the"three shells"collaborative support technology was analyzed through numerical simulation and field monitoring.The results show that the maximum displacement between the roof and floor of the coal preparation chamber in the Xinjulong coal mine was approximately 48 mm,and the maximum displacement between its two sides was approximately 65 mm,indicating that the technology proposed herein could meet the long-term control requirements of the surrounding rock stability for large-section chambers in deep mines.

Heavy Metal Pollution and Ecological Risk Assessment of Cultivated Land Soil in the Farming Areas of Coastal China:A Case Study of Donghai County,Jiangsu Province

Classical statistics,Inverse Distance Weighted and Hakasnson potential ecological index were used to study the distribution characteristics of 8 kinds of heavy metals( Cr,Ni,Cu,Zn,As,Cd,Pb and Hg) as well as their potential ecological risks in the topsoil( 0-20 cm) of cultivated land in Donghai County,a typical agricultural area along the Southeast Coast of China.The results showed that the average content of heavy metals in the cultivated soil of Donghai County was not over the risk screening values set in the Environmental Quality Standard for Soils.However,it was worth noting that in some of the sampling points,the content of Cr exceeded the risk screening value,and the standard exceeding points accounted for 24.74% of the total.In addition,the average content of Cr,Ni,As,Cd,Pb and Hg exceeded the soil background values of Jiangsu Province,and values for Cd,Cr and Pb were more than 1.5 times of the soil background value of Jiangsu Province.The heavy metals were at the medium integrated potential ecological risk level,and the potential ecological risk indices were high in the east and low in the west,and distributed in interlaced island shape.The potential ecological risk indices of the plains in the east were higher than those of the central gentle slope area and the western hillock area.The potential ecological risk was at a high level in Niushan Town which was situated the county center and in some regions with high urbanization levels.

一种铂(Ⅱ)基聚吡啶纳米药物的制备及其光热抗菌效应研究

近年来,传统抗生素药物的使用导致微生物产生严重的耐药性,给细菌性疾病的控制和治疗带来了巨大的挑战.因此,研究一种新型的抗菌药物成为当今一项新的任务.基于纳米科技的发展,光热治疗作为一种新型的抗菌技术,因其精准、高效、副作用小且无耐药性等特点,逐渐引起了人们的广泛关注.所以采用顺铂和3,4-二氨基吡啶作为前驱体,通过氧化聚合反应大规模制备了一种新型的基于铂(Ⅱ)的聚吡啶纳米药物(Pt(Ⅱ)-PDAP).该新型的Pt(Ⅱ)-PDAP纳米药物在近红外光区具有强烈的吸收,通过红外热像仪监测该纳米药物具有良好的光热转化效率和光稳定性,因此,可将其作为光热吸收试剂应用于细菌光热治疗.并且在细菌层面,Pt(Ⅱ)-PDAP纳米药物在808 nm近红外激光作用下,对大肠杆菌和金黄色葡萄球菌表现出了明显的抑制作用,其抗菌效果比单一药物或单一光照抗菌效果要好很多,体现了良好的协同治疗效果.

New evidence of Silurian hydrocarbon accumulation is discovered by fluid inclusion analysis in the South Yellow Sea Basin

1.Objective Fluid inclusions are the only way to obtain the volatile components in the process of hydrocarbon accumulation. The Marine Paleozoic strata in the South Yellow Sea Basin are of great thickness and widely distributed. The Lower Paleozoic source rocks, reservoirs and caprocks are developed and have generally good hydrocarbon geological conditions.