PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

Studies have shown that phosphatase and tensin homolog deleted on chromosome ten(PTEN)participates in the regulation of cochlear hair cell survival.Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.However,whether bisperoxovanadium can protect against noise-induced hearing loss and the underlying mechanism remains unclear.In this study,we established a mouse model of noise-induced hearing loss by exposure to 105 dB sound for 2 hours.We found that PTEN expression was increased in the organ of Corti,including outer hair cells,inner hair cells,and lateral wall tissues.Intraperitoneal administration of bisperoxovanadium decreased the auditory threshold and the loss of cochlear hair cells and inner hair cell ribbons.In addition,noise exposure decreased p-PI3K and p-Akt levels.Bisperoxovanadium preconditioning or PTEN knockdown upregulated the activity of PI3K-Akt.Bisperoxovanadium also prevented H_(2)O_(2)-induced hair cell death by reducing mitochondrial reactive oxygen species generation in cochlear explants.These findings suggest that bisperoxovanadium reduces noise-induced hearing injury and reduces cochlear hair cell loss.

Stability and Turing Patterns of a Predator-prey Model with Holling Type Ⅱ Functional Response and Allee Effect in Predator

In this paper, we are concerned with a predator-prey model with Holling type Ⅱ functional response and Allee effect in predator. We first mathematically explore how the Allee effect affects the existence and stability of the positive equilibrium for the system without diffusion. The explicit dependent condition of the existence of the positive equilibrium on the strength of Allee effect is determined. It has been shown that there exist two positive equilibria for some modulate strength of Allee effect. The influence of the strength of the Allee effect on the stability of the coexistence equilibrium corresponding to high predator biomass is completely investigated and the analytically critical values of Hopf bifurcations are theoretically determined.We have shown that there exists stability switches induced by Allee effect. Finally, the diffusion-driven Turing instability, which can not occur for the original system without Allee effect in predator, is explored, and it has been shown that there exists diffusion-driven Turing instability for the case when predator spread slower than prey because of the existence of Allee effect in predator.

Periodic Solutions of a Discrete Time Predator-Prey System

In this paper, we discuss a discrete predator-prey system with a non-monotonic functional response, which models the dynamics of the prey and the predator having non-overlapping generations. By using the coincidence degree theory, sufficient conditions are obtained for the existence of positive periodic solutions.