A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates...A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates,producing highly active ketenimines that were then treated with amines,which afforded substituted pyrroles by a S-exo-dig cyclization/isomerization in the presence of a Ag(l)catalyst in good overall yields.展开更多
基金the National Natural Science Foundation of China(No.21572075)the 111 Project B17019+1 种基金the Research Project of Hubei Provincial Department of Education(No.Q20192806)the Doctoral Research Fund of Hubei University of Science and Technology(No.BK201808).
文摘A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates,producing highly active ketenimines that were then treated with amines,which afforded substituted pyrroles by a S-exo-dig cyclization/isomerization in the presence of a Ag(l)catalyst in good overall yields.
