Interaction between systemic iron parameters and left ventricular structure and function in the preserved ejection fraction population:a two-sample bidirectional Mendelian randomization study

BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.METHODS Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies.Individuals without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset.The dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.RESULTS In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni adjustment.Conversely,no significant relationships were observed between other iron and LV parameters.After Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the analysis.CONCLUSIONS We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.

《脊柱筋出槽骨错缝临床诊疗指南》计划书

为进一步提高脊柱筋出槽骨错缝诊治水平,促进手法、功法等中医技术操作的规范化和标准化,中华中医药学会立项、上海中医药大学附属曙光医院骨伤科牵头,基于2011美国医学科学院最新指南定义,并参照世界卫生组织《WHO指南制订手册》和中华中医药学会《中医指南制定方案》,拟编制《脊柱筋出槽骨错缝临床诊疗指南》。本计划书将围绕指南制订目的和意义、应用人群、临床问题构建(PICO原则)、指南制订流程、检索策略、证据质量评价以及推荐意见形成过程等进行阐述,以期接受方法学监督,使指南编制过程规范、透明,进而提高本指南的科学性和严谨性。

Effects of nociceptin/orphanin FQ on rats with cathartic colon

AIM: To demonstrate the change and effect of nociceptin/orphanin FQ in the colon of rats with cathartic colon. METHODS: The cathartic colon model was established by feeding rats rhubarb for 3 mo, the changes of colonic electromyography were investigated by both suspension muscle strips test and serosal recordings of colonic myoelectrical activity. Immunohistochemical staining (S-P methods) and image analysis were used to determine the changes of nociceptin/orphanin FQ in the proximal colon and distal colon of rats with cathartic colon. RESULTS: Suspension muscle strips test in vitro showed OFQ (10-9-10-6 mol/L) concentration dependently caused an immediate tonic contraction in the isolated colon. But the increase of tension in cathartic colon was less than control groups (P < 0.01). Intravenous administration of OFQ (1 μg/kg) caused phasic contractions in the proximal colon, while the amplitude of phasic contractions caused by OFQ in cathartic colon was much lower than that in the control groups (2.58 ± 0.41 vs 4.16 ± 0.53, t = -2.6, P = 0.012). OFQ was highly expressed in the myenteric plexus of the rat colon but not in the muscle cells. The immunoreactivity of OFQ in the proximal colon in cathartic colon rats decreased significantly compared with the control group (P = 0.001). CONCLUSION: Colonic smooth muscle of cathartic colon showed low sensitivity to the stimulation of OFQ, suggesting that it might be caused by the abnormal distribution of OFQ or the abnormalities of receptors, leading to the disorganization of dynamic and incoordinated contractions.

The Possibility of Changing the Wettability of Material Surface by Adjusting Gravity

The contact angle,as a vital measured parameter of wettability of material surface,has long been in dispute whether it is affected by gravity.Herein,we measured the advancing and receding contact angles on extremely low contact angle hysteresis surfaces under different gravities(1-8G)and found that both of them decrease with the increase of the gravity.The underlying mechanism is revealed to be the contact angle hysteresis and the deformation of the liquid-vapor interface away from the solid surface caused by gradient distribution of the hydrostatic pressure.The real contact angle is not affected by gravity and cannot measured by an optical method.The measured apparent contact angles are angles of inclination of the liquid-vapor interface away from the solid surface.Furthermore,a new equation is proposed based on the balance of forces acting on the three-phase contact region,which quantitatively reveals the relation of the apparent contact angle with the interfacial tensions and gravity.This finding can provide new horizons for solving the debate on whether gravity affects the contact angle and may be useful for the accurate measurement of the contact angle and the development of a new contact angle measurement system.

A ladder conjugated polymer transducer for solid-contact Cu^(2+)-selective electrodes

In recent years, there has been a pronounced interest in solid-contact ion-selective electrodes （SC-ISEs）, with emphasis on the use of conducting polymers as ion-to-electron transducer. In this work, a ladder conjugated polymer, thieno[3,2-b]thiophene （LCPT）, was investigated in fabricating Cu2＋-selective electrodes for the first time. The resulting electrodes were characterized by electrochemical impedance spectroscopy （EIS）, chronopotentiometry, and the water layer test. Results proved that the active LCPT facilitates the ion-to-electron transduction, and avoids the detrimental aqueous layer formed at the interface of SC-ISEs.

Erratum to“The Possibility of Changing the Wettability of Material Surface by Adjusting Gravity”

In the article titled“The Possibility of Changing the Wettability of Material Surface by Adjusting Gravity”[1],there were errors in Figure 2 which occurred during production.These errors are listed below,and the corrected version is shown as Figure 1.