Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplasma pneumonia (MP) infection in different stages and its clinical significance. Methods: A total of 100 children ...Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplasma pneumonia (MP) infection in different stages and its clinical significance. Methods: A total of 100 children with MPP hospitalized from September 2014 to May 2015 were selected as the observation group and divided into two groups of MPP acute period and recovery period on the basis of the infection degree, and 50 healthy children were selected as control group at the same time, detect the immunoglobulin (IgG, IgA, IgM) and complement (C3, C4), peripheral T lymphocyte subsets (CD3+, CD4+, CD8+) and inflammatory factors (IL-2, IL-6, TNF-α, IL-8, IL-10, IL-13) of three groups of infants.Results:immunoglobulin IgG levels of recovery period were significantly higher than that in acute stage and the control group, IgA levels of acute phase and recovery phase were significantly lower than the control group, IgM and complement C3 levels in acute stage were significantly higher than the control group, during the recovery period tended to be normal, complement C4 in acute stage levels were significantly higher than those in recovery period and both higher than the control group. The CD3+, CD4+ and CD4/CD8 ratio of MPP in acute stage and recovery phase were significantly lower than the control group, and these numerical indexes of the recovery period were significantly higher than the acute stage, CD8+ levels in acute stage were significantly higher than that in recovery period and both higher than control group. Compared with the control group ,The levels of inflammatory cytokines IL-2 in the acute phase and recovery phase were significantly decreased, and the recovery period was significantly higher than that in acute stage, the test results that the levels of IL-6, TNF-α, IL-8, IL-10 and IL-13 in acute phase and recovery phase were significantly higher than those in control group and the recovery period was significantly lower than that in the acute stage.Conclusion:The body humoral immune function and cellular immune function damage caused by MP infection in infants and young children could lead to the disorder of immune system and the abnormal expression of inflammatory cytokines. Therefore, Therefore, the real-time monitoring the dynamic level of the indicators can define the infants and young children's condition, improve the recovery rate, and have a certain guiding significance of the clinical diagnosis of infants and young children .展开更多
文摘Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplasma pneumonia (MP) infection in different stages and its clinical significance. Methods: A total of 100 children with MPP hospitalized from September 2014 to May 2015 were selected as the observation group and divided into two groups of MPP acute period and recovery period on the basis of the infection degree, and 50 healthy children were selected as control group at the same time, detect the immunoglobulin (IgG, IgA, IgM) and complement (C3, C4), peripheral T lymphocyte subsets (CD3+, CD4+, CD8+) and inflammatory factors (IL-2, IL-6, TNF-α, IL-8, IL-10, IL-13) of three groups of infants.Results:immunoglobulin IgG levels of recovery period were significantly higher than that in acute stage and the control group, IgA levels of acute phase and recovery phase were significantly lower than the control group, IgM and complement C3 levels in acute stage were significantly higher than the control group, during the recovery period tended to be normal, complement C4 in acute stage levels were significantly higher than those in recovery period and both higher than the control group. The CD3+, CD4+ and CD4/CD8 ratio of MPP in acute stage and recovery phase were significantly lower than the control group, and these numerical indexes of the recovery period were significantly higher than the acute stage, CD8+ levels in acute stage were significantly higher than that in recovery period and both higher than control group. Compared with the control group ,The levels of inflammatory cytokines IL-2 in the acute phase and recovery phase were significantly decreased, and the recovery period was significantly higher than that in acute stage, the test results that the levels of IL-6, TNF-α, IL-8, IL-10 and IL-13 in acute phase and recovery phase were significantly higher than those in control group and the recovery period was significantly lower than that in the acute stage.Conclusion:The body humoral immune function and cellular immune function damage caused by MP infection in infants and young children could lead to the disorder of immune system and the abnormal expression of inflammatory cytokines. Therefore, Therefore, the real-time monitoring the dynamic level of the indicators can define the infants and young children's condition, improve the recovery rate, and have a certain guiding significance of the clinical diagnosis of infants and young children .
