AIM:To evaluate the efficacy and safety of lamivudine treatment of chronic hepatitis B disease in pregnancy.METHODS:The study group was comprised of 38 chronic HBV patients who were diagnosed pregnant during lamivudin...AIM:To evaluate the efficacy and safety of lamivudine treatment of chronic hepatitis B disease in pregnancy.METHODS:The study group was comprised of 38 chronic HBV patients who were diagnosed pregnant during lamivudine treatment and voluntary to continue the same therapy.The control group was from documented patient data in the literatures.We compared the following parameters with those of a control group: anti-HBV efficacy,complications of pregnancy (abortion, preterm birth, neonatal asphyxia,fetal death, and congenital anomaly), incidence of HBV-positive babies and developmental anomalies in pregnant women treated with lamivudine.RESULTS:The blocking rate of lamivudine treatment was significantly higher than that of active vaccine immunization for babies with double-positive (HBsAg/HBeAg) mothers with 30-30-10μg doses of vaccine (74.07%) and with 30-20-10μg (64.87%）.The natural vertical HBV transmission from mother to infant of “double-positive” mothers was 100% (10/10).No pregnancy complication was noted during the observation period,but in the control group the incidences of pregnancy complication were 16.67% (abortion), 43.02%(preterm),15.62% (neonatal asphyxia),and 4.49% (fetal death),10.0% (congenital anomaly).No HBV-positive newborn was detected and no developmental anomaly was found in the study group.CONCLUSION: Lamivudine is helpful to prevent maternalinfant HBV transmission and may reduce the complications of HBV-infected pregnant patients.展开更多
AIM: To assess the effectiveness and safety of perioperative growth hormone (GH) in patients undergoing abdominal surgery.METHODS: We searched the following electronic databases: MEDLINE, EMBASE, the Cochrane Controll...AIM: To assess the effectiveness and safety of perioperative growth hormone (GH) in patients undergoing abdominal surgery.METHODS: We searched the following electronic databases: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, Chinese Bio-medicine Database. The search was undertaken in February 2003. No language restrictions were applied. Randomized controlled trials (RCT) comparing GH with placebo in patients undergoing abdominal surgery were extracted and evaluated.Methodological quality was evaluated using the Jadad scale.RESULTS: Eighteen trials involving 646 patients were included. The combined results showed that GH had a positive effect on improving postoperative nitrogen balance (standardized mean difference [SMD] = 3.37, 95%CI [2.46, 4.27], P＜0.00001), and decreasing the length of hospital stay (weighted mean difference [WMD] = -2.07,95%CI [-3.03, -1.11], P = 0.00002), and reducing the duration of postoperative fatigue syndrome (SMD = -1.83,95%CI [-2.37, -1.30], P＜0.00001), but it could increase blood glucose levels (WMD = 0.91, 95%CI [0.56, 1.25],P＜0.00001).CONCLUSION: GH for patients undergoing abdominal surgery is effective and safe, if blood glucose can be controlled well. Further trials are required with a sufficient size to account for clinical heterogeneity and to measure other important outcomes such as infection, morbidity,mortality, fluid retention, immunomodulatory effects, and tumor recurrence.展开更多
AIM: To evaluate the effects of n-3 fatty acids (n-3FA),fructose-l,6-diphosphate (FDP) and glutamine (GLN) on mucosal cell proliferation and apoptosis of small bowel graft.METHODS: One hundred and ninety-six inbred st...AIM: To evaluate the effects of n-3 fatty acids (n-3FA),fructose-l,6-diphosphate (FDP) and glutamine (GLN) on mucosal cell proliferation and apoptosis of small bowel graft.METHODS: One hundred and ninety-six inbred strain Wistar rats were grouped as donors and recipients, and underwent heterotopic small bowel transplantation (SBT). n-3FA, FDP and GLN were administered via gastric tube as well as venous infusion for 10 days before and after surgery, respectively.The proliferation and apoptosis of mucosal cells were analyzed with flow cytometry and in situ cell death detection kits.RESULTS: Apparent apoptosis and minor proliferation of mucosal cells of small bowel graft after transplantation were observed. A higher mucosal cell proliferative index and lower apoptotic index were found in all small bowel grafts after supplying with n-3FA, FDP and GLN.CONCLUSION: Nutritional support with n-3FA, FDP and GLN promotes mucosal cell proliferation significantly, and prevents mucosal cell from undergoing apoptosis with different degrees. These regulatory effects on the apoptosis alter the structure and absorption function of transplanted small bowel favorably.展开更多
文摘AIM:To evaluate the efficacy and safety of lamivudine treatment of chronic hepatitis B disease in pregnancy.METHODS:The study group was comprised of 38 chronic HBV patients who were diagnosed pregnant during lamivudine treatment and voluntary to continue the same therapy.The control group was from documented patient data in the literatures.We compared the following parameters with those of a control group: anti-HBV efficacy,complications of pregnancy (abortion, preterm birth, neonatal asphyxia,fetal death, and congenital anomaly), incidence of HBV-positive babies and developmental anomalies in pregnant women treated with lamivudine.RESULTS:The blocking rate of lamivudine treatment was significantly higher than that of active vaccine immunization for babies with double-positive (HBsAg/HBeAg) mothers with 30-30-10μg doses of vaccine (74.07%) and with 30-20-10μg (64.87%）.The natural vertical HBV transmission from mother to infant of “double-positive” mothers was 100% (10/10).No pregnancy complication was noted during the observation period,but in the control group the incidences of pregnancy complication were 16.67% (abortion), 43.02%(preterm),15.62% (neonatal asphyxia),and 4.49% (fetal death),10.0% (congenital anomaly).No HBV-positive newborn was detected and no developmental anomaly was found in the study group.CONCLUSION: Lamivudine is helpful to prevent maternalinfant HBV transmission and may reduce the complications of HBV-infected pregnant patients.
基金Supported by the China Medical Board of New York No. 98-680
文摘AIM: To assess the effectiveness and safety of perioperative growth hormone (GH) in patients undergoing abdominal surgery.METHODS: We searched the following electronic databases: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, Chinese Bio-medicine Database. The search was undertaken in February 2003. No language restrictions were applied. Randomized controlled trials (RCT) comparing GH with placebo in patients undergoing abdominal surgery were extracted and evaluated.Methodological quality was evaluated using the Jadad scale.RESULTS: Eighteen trials involving 646 patients were included. The combined results showed that GH had a positive effect on improving postoperative nitrogen balance (standardized mean difference [SMD] = 3.37, 95%CI [2.46, 4.27], P＜0.00001), and decreasing the length of hospital stay (weighted mean difference [WMD] = -2.07,95%CI [-3.03, -1.11], P = 0.00002), and reducing the duration of postoperative fatigue syndrome (SMD = -1.83,95%CI [-2.37, -1.30], P＜0.00001), but it could increase blood glucose levels (WMD = 0.91, 95%CI [0.56, 1.25],P＜0.00001).CONCLUSION: GH for patients undergoing abdominal surgery is effective and safe, if blood glucose can be controlled well. Further trials are required with a sufficient size to account for clinical heterogeneity and to measure other important outcomes such as infection, morbidity,mortality, fluid retention, immunomodulatory effects, and tumor recurrence.
基金the State Education Commission Research Foundation for Returned Overseas Chinese Scholars Abroad(1997)436
文摘AIM: To evaluate the effects of n-3 fatty acids (n-3FA),fructose-l,6-diphosphate (FDP) and glutamine (GLN) on mucosal cell proliferation and apoptosis of small bowel graft.METHODS: One hundred and ninety-six inbred strain Wistar rats were grouped as donors and recipients, and underwent heterotopic small bowel transplantation (SBT). n-3FA, FDP and GLN were administered via gastric tube as well as venous infusion for 10 days before and after surgery, respectively.The proliferation and apoptosis of mucosal cells were analyzed with flow cytometry and in situ cell death detection kits.RESULTS: Apparent apoptosis and minor proliferation of mucosal cells of small bowel graft after transplantation were observed. A higher mucosal cell proliferative index and lower apoptotic index were found in all small bowel grafts after supplying with n-3FA, FDP and GLN.CONCLUSION: Nutritional support with n-3FA, FDP and GLN promotes mucosal cell proliferation significantly, and prevents mucosal cell from undergoing apoptosis with different degrees. These regulatory effects on the apoptosis alter the structure and absorption function of transplanted small bowel favorably.
