Owing to the constant modernization and urbanization of China,most cities have subways,and the total power consumption of subway stations has been rising,which contradicts with China’s green goals.In this regard,ener...Owing to the constant modernization and urbanization of China,most cities have subways,and the total power consumption of subway stations has been rising,which contradicts with China’s green goals.In this regard,energy consumption indicators for major energy use projects in subway stations should be established,comprehensive evaluation and detailed research on the current situation of subway operation should be conducted,and specific energy-saving measures should be taken from a diversified perspective.It is crucial to systematically sort out the principle of sub-item energy consumption in subway stations,and practice and explore the specific simplification measures of the principle model of sub-item energy consumption,so as to lay a solid foundation for achieving the goal of reducing energy consumption of subway stations.展开更多
The solution purification process is an essential step in zinc hydrometallurgy. The performance of solution purification directly affects the normal functioning and economical benefits of zinc hydrometallurgy. This pa...The solution purification process is an essential step in zinc hydrometallurgy. The performance of solution purification directly affects the normal functioning and economical benefits of zinc hydrometallurgy. This paper summarizes the authors' recent work on the modeling, optimization, and control of solution purification process. The online measurable property of the oxidation reduction potential(ORP) and the multiple reactors, multiple running statuses characteristic of the solution purification process are extensively utilized in this research. The absence of reliable online equipment for detecting the impurity ion concentration is circumvented by introducing the oxidationreduction potential into the kinetic model. A steady-state multiple reactors gradient optimization, unsteady-state operationalpattern adjustment strategy, and a process evaluation strategy based on the oxidation-reduction potential are proposed. The effectiveness of the proposed research is demonstrated by its industrial experiment.展开更多
The past few decades have witnessed rapid gains in our demands of antifouling membranes such as water purification membranes and hemodialysis membranes.A variety of methodologies have been proposed for improving the a...The past few decades have witnessed rapid gains in our demands of antifouling membranes such as water purification membranes and hemodialysis membranes.A variety of methodologies have been proposed for improving the antifouling performance and the hemocompatibility of the membranes.In this study,a series of copolymers(PSF-PESSB)containing polysulfone(PSF)and poly(arylene ether sulfone)bearing pendant zwitterionic sulfobetaine groups(PESSB)were prepared via one-pot polycondensation.Subsequently,the ultrafiltration(UF)membranes were prepared from different zwitterion-containing copolymers.The prepared membranes showed high thermal stability and mechanical properties.Besides,it also displayed attractive antifouling performance and blood compatibility.Compared with the original PSF membrane,the amount of protein absorption on the modified membrane was reduced;the flux recovery ratio and the resistance to blood cells were significantly improved.The results of this work suggest that PSF-PESSB membranes are expected to be applied in blood purification.The introduction of zwitterion-containing polymers to membranes paves ways for developing advanced hemodialysis technologies for crucial process.展开更多
Suppose that A and B are two positive-definite matrices,then,the limit of(A^p/2B^pA^p/2)1/p as p tends to 0 can be obtained by the well known Lie-Trotter formula.In this article,we generalize the usual product of matr...Suppose that A and B are two positive-definite matrices,then,the limit of(A^p/2B^pA^p/2)1/p as p tends to 0 can be obtained by the well known Lie-Trotter formula.In this article,we generalize the usual product of matrices to the Hadamard product denoted as*which is commutative,and obtain the explicit formula of the limit(A^p*B^p)^1/p as p tends to 0.Furthermore,the existence of the limit of(A^p*B^p)^1/p as p tends to+∞is proved.展开更多
The uncertainty principle proposed by German physicist Heisenberg in 1927 is a basic principle of quantum mechanics and signal processing.Since linear canonical transformation has been widely used in various fields of...The uncertainty principle proposed by German physicist Heisenberg in 1927 is a basic principle of quantum mechanics and signal processing.Since linear canonical transformation has been widely used in various fields of signal processing recently and Heisenberg uncertainty principle has been endowed with new expressive meaning in linear canonical transforms domain,in this manuscript,an improved Heisenberg uncertainty principle is obtained in linear canonical trans-forms domain.展开更多
<span style="font-family:""><span style="font-family:Verdana;">Unicondylar Knee Arthroplasty (UKA) is an early alternative surgical procedure for the unicondylar osteoarthritis or ...<span style="font-family:""><span style="font-family:Verdana;">Unicondylar Knee Arthroplasty (UKA) is an early alternative surgical procedure for the unicondylar osteoarthritis or damaged knee joint with artificial </span><span style="font-family:Verdana;">prosthesis for the release of disabling painful condition and restoring the</span><span style="font-family:Verdana;"> normal knee functions. Minimally UKA is one of the recent and the majority successful procedures in modern orthopedics for the osteoarthritis which is spreading throughout the worldwide. Recently, many orthopedic surgeons are expanding their abilities in this field. However, it needs good knowledge and well experience for the successful clinical outcomes. The minimal invasive approach is more efficient for short hospital stay and faster postoperative recovery with low morbidity of the patients after UKA. The aim of this article is to emphasize the steps in UKA based on modern facts: function of knee joint, diagnosis, less invasive approach for medial condylar replacement, radiographic evaluation, and earlier recovery, selecting the patient and implant survivorship with review of surgery.展开更多
The new generation of biomaterials focuses on the design of biomimetic polymeric materials that are capable of eliciting specific cellular responses and directing new tissue formation. Since Arg-Gly-Asp (RGD) sequence...The new generation of biomaterials focuses on the design of biomimetic polymeric materials that are capable of eliciting specific cellular responses and directing new tissue formation. Since Arg-Gly-Asp (RGD) sequences have been found to promote cell adhesion in 1984, numerous polymers have been functionalized with RGD peptides for tissue engineering applications. This review gave the advance in RGD modified biomimetic polymeric materials,focusing on the mechanism of RGD, the surface and bulk modification of polymer with RGD peptides and the evaluation in vitro and in vivo of the modified biomimetic materials.展开更多
Data-driven process-monitoring methods have been the mainstream for complex industrial systems due to their universality and the reduced need for reaction mechanisms and first-principles knowledge.However,most data-dr...Data-driven process-monitoring methods have been the mainstream for complex industrial systems due to their universality and the reduced need for reaction mechanisms and first-principles knowledge.However,most data-driven process-monitoring methods assume that historical training data and online testing data follow the same distribution.In fact,due to the harsh environment of industrial systems,the collected data from real industrial processes are always affected by many factors,such as the changeable operating environment,variation in the raw materials,and production indexes.These factors often cause the distributions of online monitoring data and historical training data to differ,which induces a model mismatch in the process-monitoring task.Thus,it is difficult to achieve accurate process monitoring when a model learned from training data is applied to actual online monitoring.In order to resolve the problem of the distribution divergence between historical training data and online testing data that is induced by changeable operation environments,a robust transfer dictionary learning(RTDL)algorithm is proposed in this paper for industrial process monitoring.The RTDL is a synergy of representative learning and domain adaptive transfer learning.The proposed method regards historical training data and online testing data as the source domain and the target domain,respectively,in the transfer learning problem.Maximum mean discrepancy regularization and linear discriminant analysis-like regularization are then incorporated into the dictionary learning framework,which can reduce the distribution divergence between the source domain and target domain.In this way,a robust dictionary can be learned even if the characteristics of the source domain and target domain are evidently different under the interference of a realistic and changeable operation environment.Such a dictionary can effectively improve the performance of process monitoring and mode classification.Extensive experiments including a numerical simulation and two industrial systems are conducted to verify the efficiency and superiority of the proposed method.展开更多
Objective.To understand and analyze the mental health status of key Senior School Students at grade 3 in Haidian District of Bey ing and Senior Three Students in General Schools,so as to provide basis for mental healt...Objective.To understand and analyze the mental health status of key Senior School Students at grade 3 in Haidian District of Bey ing and Senior Three Students in General Schools,so as to provide basis for mental health education and psychological intervention.Methods.A total of 263 senior three students were randomly selected from a general school and two key school in Haidian District of Beijing.A questionnaire survey was conducted using the Mental Health Scale for Chinese Middle School Students(MSSMHS).Results.Of the 260 students surveyed,54.2%had mental health problems,36.5%had mild problems,8.8%had moderate problems,and 0.5%had slightly and deeply serious problems.The first three factors about examined rates of factors of mental health were anxiety,learning and interpersonal relationship.The detection rates accounted for 23.5%,23.1%and 18.8%respectively.There was no significant difference in the scores of each factor between key and ordinary middle school students(P>0.05).The scores of interpersonal,depression,anxiety and emotional factors of middle school girls were higher than those of boys,with statistical significance(P<0.05)?Conclusion.There are some mental health problems among senior students at grade 3 in Haidian District of Beijing,and female students9 are serious.Schools,families and societies should pay attention to this problem and strengthen mental health education with a focused goal.展开更多
Based on the perspective of psychology,this paper analyzes the causes and characteristics of college students’network mass incidents,explores the psychological factors of college students’network mass incidents,and ...Based on the perspective of psychology,this paper analyzes the causes and characteristics of college students’network mass incidents,explores the psychological factors of college students’network mass incidents,and puts forward the educational strategies to solve college students’network mass incidents:(1)Adhere to humanism and take appeals as the center;(2)To improve the campus network public opinion guidance mechanism under the guidance of relevant social cognition theories;(3)Strengthen communication and improve communication skills;(4)Promote information disclosure and transparency,and eliminate uncertainty and ambiguity.展开更多
Highly efficient persistent organic room temperature phosphorescence(RTP) has attracted increasing attention because of promising applications in fields of chemical sensors, optoelectronic devices, information securit...Highly efficient persistent organic room temperature phosphorescence(RTP) has attracted increasing attention because of promising applications in fields of chemical sensors, optoelectronic devices, information security, and bioimaging, etc. Wherein,the crystal engineering of H-aggregation offers stabilization for long-lived triplet exciton for RTP, but the related research is rare because of the scarcity of ideal phosphorescent H-aggregate. Herein, we designed planar tricoordinate organoboron derivatives with molecular arrangement in ideal H-aggregation. The integration of Br atom can largely enhance RTP efficiency through increasing SOC effect, while the antiparallel molecular arrangement causes annihilation of triplet exciton. Thanks to good selfassembly property, their RTP can even be observed in PMMA matrix with doping ratio of merely 1 wt%. We further found that the cryogenic temperature contributes to stabilizing triplet exciton in H-aggregation, leading to red-shifted phosphorescence. By applying high hydrostatic pressure, the phosphorescence was largely enhanced and redshifted, demonstrating the crucial role of H-aggregation on RTP property. In phosphorescent tissue imaging of live mouse, nanoparticles of BrBA exhibited high contrast image via eliminating the interference of autofluorescence.展开更多
Based on the perspective of psychology,this paper analyzes the causes and characteristics of college students’network mass incidents,explores the psychological factors of college students’network mass incidents,and ...Based on the perspective of psychology,this paper analyzes the causes and characteristics of college students’network mass incidents,explores the psychological factors of college students’network mass incidents,and puts forward the educational strategies to solve college students’network mass incidents:No.1.Adhere to humanism and take appeals as the center;No.2.To improve the campus network public opinion guidance mechanism under the guidance of relevant social cognition theories;No.3.Strengthen communication and improve communication skills;No.4.Promote information disclosure and transparency,and eliminate uncertainty and ambiguity.展开更多
China.In this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing region.Methods:In this retrospective study,we enrolled inpatients...China.In this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing region.Methods:In this retrospective study,we enrolled inpatients admitted for COVID-19 in the Fifth Medical Center of Chinese PLA General Hospital in Beijing between November 10,2022,and January 30,2023.Demographic and clinical features and treatment outcomeswere comprehensively analyzed.We used logistic regression and linear regression analyses to explore the risk factors associated with disease severity and time of nucleic acid conversion,respectively.Results:A total of 1010 hospitalized patients with COVID-19 were enrolled.The median age was 43.0 years(interquartile range,28.0–63.0),and patients aged<60 years and≥60 years comprised 71.2%and 28.8%of total included patients,respectively.The clinical classification of mild(74.6%,753/1010),moderate(21.0%,212/1010),severe(2.7%,27/1010),and unidentified(1.8%,18/1010)was separately recorded;1005 patients were discharged,and 5 patients died in the hospital.The outbreak of the emerging epidemic witnessed an evident increase in the proportion of moderate(42.9%vs.16.4%)and severe(10.3%vs.1.1%)cases after December 7,2022.Patients with a moderate/severe classification had higher levels of procalcitonin,IL-6,serum ferritin,C-reactive protein,lactic dehydrogenase,serum urea nitrogen,and D-dimer and lower counts of CD4+T,CD8+T,and B cells(all P<0.001).Multivariable regression analysis revealed that increased odds of disease severity were associated with the following factors:age≥60 years,IL-6>7 pg/mL,lactic dehydrogenase level>245 U/L,cough,and fever at admission.Age≥80 years and chronic lung diseasewere independent risk factors in the nonmild group in elderly patients.In addition,the duration for nucleic acid to turn negativewas approximately 5.0 d(interquartile range,3.0–7.0).Prolonged time of nucleic acid conversion was associated with age≥60 years,serum urea nitrogen level>8.2 mmol/L,neutrophil count>7×10^(9)/L,and the presence of a chronic lung disease or carcinoma.Finally,unvaccinated patients accounted for 37.3%of enrolled patients;children and the elder people accounted for approximately half of that.The univariable analysis found that booster doses reduced disease severity and shortened the time of nucleic acid conversion in elderly patients.Conclusions:The outbreak ofOmicron rapidly increased the number of patientswith COVID-19 in Beijing.In elderly patients,booster doses may reduce disease severity and shorten the time of nucleic acid conversion.Healthcare systems should be optimized before an emerging epidemic outbreak.展开更多
Urban subways have developed rapidly in recent years and has gradually become the primary choice of public transportation in big cities.Subways can effectively alleviate urban traffic congestion and improve passengers...Urban subways have developed rapidly in recent years and has gradually become the primary choice of public transportation in big cities.Subways can effectively alleviate urban traffic congestion and improve passengers’green travel experience,especially in the old urban areas where urban space is limited,community facilities are aging and historical features are gathered.Subways play a huge role in guiding the expansion of urban space form and improving urban landscape environment.As the only channel for passengers to get in and out of the station,the subway entrance and exit act as a bridge.It is not only the transition space between the subway station space and the urban above ground space,but also an important node for the exchange and circulation of various elements in the urban space.In this paper,the influencing factors of subway entrance and exit space environments in the old city were investigated,and relevant basis for future planning,design,and construction of subway entrances and exits were provided.Firstly,the research results and shortcomings of subway entrance and exit channels were outlined.Secondly,based on the perspective of residents and passengers,this paper uses the analytic hierarchy process to determine six first-class evaluation indexes,including safety,convenience,practicability and aesthetics.This paper constructs the evaluation system of spatial environment index of subway station entrances and exits in the old urban area of Xi’an.Lastly,according to the evaluation results,the paper puts forward the targeted optimization strategies for the current situation of the entrance and exit space environment of the subway stations in the Xi’an.展开更多
Background:Femoral interlocking intramedullary(IM)nailing fixation is an effective method for the treatment of femoral shaft fractures.Aseptic nonunion of femoral shaft fracture after IM nailing is uncommon.Currently,...Background:Femoral interlocking intramedullary(IM)nailing fixation is an effective method for the treatment of femoral shaft fractures.Aseptic nonunion of femoral shaft fracture after IM nailing is uncommon.Currently,the treatment for aseptic femoral shaft nonunion is controversial.The aim of this study was to investigate the clinical effect of augmentative antirotational plating plus decortication and autogenic bone grafting for aseptic femoral shaft nonunion after IM nailing failure.Methods:A retrospective study was conducted on 25 cases of aseptic femoral shaft fracture nonunion treated with IM nailing from January 2015 to August 2019.All patients were treated by leaving the nail in situ,debridement of nonunionsites,decortication,autogenous iliac bone grafting,and augmentative antirotational plating fixation.The time to fracture union and complications were recorded.Results:All patients were followed up for 12–18 months.The union rate after revision surgery was 100%.The average union time was 5.5months(range,4-10).Subjective pain symptoms had disappeared in all patients.There were no incision infections or internal fixator fatigue fractures.Average scores of the physical function and bodily pain components of the SF-36 were 95.5(range,91-98)and 94.1(range,90-97),respectively.No other obvious complications occurred postoperatively.Conclusion:Augmentative antirotational plating plus decortication and autogenic bone grafting is an excellent choice for treating femoral shaft fracture nonunion after IM nailing;this approach has an overall high union rate and few complications.展开更多
The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the worl...The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the world according to the declaration from World Health Organization.Dysregulated immune response of both the innate and adaptive immune systems is subsistent on COVID-19 patients,of which the degree are associated with disease severity,lung damage and long term functional disability.Current treatment options have included antiretroviral drugs,anti-inflammatory factors,antibodies,immune checkpoint inhibitors,and convalescent plasma therapy.More recently,mesenchymal stem cell(MSC)therapy has been explored for the management and control of COVID-19,particularly with the aim of preventing or at least mitigating respiratory co-morbidities.Though the safety and efficacy of stem cell therapy have been validated in multiple phase I–III clinical trials,to date,no standardized stem cell preparation,administration dosage or interval,product QA/QC testing,storage,transportation,or disposal protocols have been established.The present paper proposes a systematic methodology that addresses all the foregoing process steps and evaluation criteria for the efficacious and safe administration of MSCs in the treatment of patients infected with COVID-19.展开更多
Congenital diaphragmatic hernia is a congenital fetal disease,which mainly causes pulmonary hypoplasia and pulmonary hypertension.Effective early prenatal diagnosis can detect and predict the prognosis of congenital d...Congenital diaphragmatic hernia is a congenital fetal disease,which mainly causes pulmonary hypoplasia and pulmonary hypertension.Effective early prenatal diagnosis can detect and predict the prognosis of congenital diaphragmatic hernia in infants,thus provide a reference for prenatal counseling,early intervention,and potential choices for the child’s family.Ultrasound and magnetic resonance imaging are the most commonly used methods for non-invasive examination of the fetus.This paper discusses evaluation parameters based on these two imaging modalities.展开更多
文摘Owing to the constant modernization and urbanization of China,most cities have subways,and the total power consumption of subway stations has been rising,which contradicts with China’s green goals.In this regard,energy consumption indicators for major energy use projects in subway stations should be established,comprehensive evaluation and detailed research on the current situation of subway operation should be conducted,and specific energy-saving measures should be taken from a diversified perspective.It is crucial to systematically sort out the principle of sub-item energy consumption in subway stations,and practice and explore the specific simplification measures of the principle model of sub-item energy consumption,so as to lay a solid foundation for achieving the goal of reducing energy consumption of subway stations.
基金supported by the National Natural Science Foundation of China(61603418,61673400,61273185)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(61621062)the Innovation-driven Plan in Central South University(2015cx007)
文摘The solution purification process is an essential step in zinc hydrometallurgy. The performance of solution purification directly affects the normal functioning and economical benefits of zinc hydrometallurgy. This paper summarizes the authors' recent work on the modeling, optimization, and control of solution purification process. The online measurable property of the oxidation reduction potential(ORP) and the multiple reactors, multiple running statuses characteristic of the solution purification process are extensively utilized in this research. The absence of reliable online equipment for detecting the impurity ion concentration is circumvented by introducing the oxidationreduction potential into the kinetic model. A steady-state multiple reactors gradient optimization, unsteady-state operationalpattern adjustment strategy, and a process evaluation strategy based on the oxidation-reduction potential are proposed. The effectiveness of the proposed research is demonstrated by its industrial experiment.
基金financially supported by the National Natural Science Foundation of China(52003266,21961160739)the Development of Scientific and Technological Project of the Jilin Province(YDZJ202101ZYTS162,20200801051GH)Chinese Academy of Sciences-Wego Group High-tech Research&Development。
文摘The past few decades have witnessed rapid gains in our demands of antifouling membranes such as water purification membranes and hemodialysis membranes.A variety of methodologies have been proposed for improving the antifouling performance and the hemocompatibility of the membranes.In this study,a series of copolymers(PSF-PESSB)containing polysulfone(PSF)and poly(arylene ether sulfone)bearing pendant zwitterionic sulfobetaine groups(PESSB)were prepared via one-pot polycondensation.Subsequently,the ultrafiltration(UF)membranes were prepared from different zwitterion-containing copolymers.The prepared membranes showed high thermal stability and mechanical properties.Besides,it also displayed attractive antifouling performance and blood compatibility.Compared with the original PSF membrane,the amount of protein absorption on the modified membrane was reduced;the flux recovery ratio and the resistance to blood cells were significantly improved.The results of this work suggest that PSF-PESSB membranes are expected to be applied in blood purification.The introduction of zwitterion-containing polymers to membranes paves ways for developing advanced hemodialysis technologies for crucial process.
基金H.Sun is supported by NSFC(61179031)J.Wang is supported by General Project of Science and Technology Plan of Beijing Municipal Education Commission(KM202010037003).
文摘Suppose that A and B are two positive-definite matrices,then,the limit of(A^p/2B^pA^p/2)1/p as p tends to 0 can be obtained by the well known Lie-Trotter formula.In this article,we generalize the usual product of matrices to the Hadamard product denoted as*which is commutative,and obtain the explicit formula of the limit(A^p*B^p)^1/p as p tends to 0.Furthermore,the existence of the limit of(A^p*B^p)^1/p as p tends to+∞is proved.
文摘The uncertainty principle proposed by German physicist Heisenberg in 1927 is a basic principle of quantum mechanics and signal processing.Since linear canonical transformation has been widely used in various fields of signal processing recently and Heisenberg uncertainty principle has been endowed with new expressive meaning in linear canonical transforms domain,in this manuscript,an improved Heisenberg uncertainty principle is obtained in linear canonical trans-forms domain.
文摘<span style="font-family:""><span style="font-family:Verdana;">Unicondylar Knee Arthroplasty (UKA) is an early alternative surgical procedure for the unicondylar osteoarthritis or damaged knee joint with artificial </span><span style="font-family:Verdana;">prosthesis for the release of disabling painful condition and restoring the</span><span style="font-family:Verdana;"> normal knee functions. Minimally UKA is one of the recent and the majority successful procedures in modern orthopedics for the osteoarthritis which is spreading throughout the worldwide. Recently, many orthopedic surgeons are expanding their abilities in this field. However, it needs good knowledge and well experience for the successful clinical outcomes. The minimal invasive approach is more efficient for short hospital stay and faster postoperative recovery with low morbidity of the patients after UKA. The aim of this article is to emphasize the steps in UKA based on modern facts: function of knee joint, diagnosis, less invasive approach for medial condylar replacement, radiographic evaluation, and earlier recovery, selecting the patient and implant survivorship with review of surgery.
基金supported by the National Natural Science Foundation of China under grant No.30300084the Key Scientific and Technological Foundation of the State Ministry of Education in China.
文摘The new generation of biomaterials focuses on the design of biomimetic polymeric materials that are capable of eliciting specific cellular responses and directing new tissue formation. Since Arg-Gly-Asp (RGD) sequences have been found to promote cell adhesion in 1984, numerous polymers have been functionalized with RGD peptides for tissue engineering applications. This review gave the advance in RGD modified biomimetic polymeric materials,focusing on the mechanism of RGD, the surface and bulk modification of polymer with RGD peptides and the evaluation in vitro and in vivo of the modified biomimetic materials.
基金This work was supported in part by the National Natural Science Foundation of China(61988101)in part by the National Key R&D Program of China(2018YFB1701100).
文摘Data-driven process-monitoring methods have been the mainstream for complex industrial systems due to their universality and the reduced need for reaction mechanisms and first-principles knowledge.However,most data-driven process-monitoring methods assume that historical training data and online testing data follow the same distribution.In fact,due to the harsh environment of industrial systems,the collected data from real industrial processes are always affected by many factors,such as the changeable operating environment,variation in the raw materials,and production indexes.These factors often cause the distributions of online monitoring data and historical training data to differ,which induces a model mismatch in the process-monitoring task.Thus,it is difficult to achieve accurate process monitoring when a model learned from training data is applied to actual online monitoring.In order to resolve the problem of the distribution divergence between historical training data and online testing data that is induced by changeable operation environments,a robust transfer dictionary learning(RTDL)algorithm is proposed in this paper for industrial process monitoring.The RTDL is a synergy of representative learning and domain adaptive transfer learning.The proposed method regards historical training data and online testing data as the source domain and the target domain,respectively,in the transfer learning problem.Maximum mean discrepancy regularization and linear discriminant analysis-like regularization are then incorporated into the dictionary learning framework,which can reduce the distribution divergence between the source domain and target domain.In this way,a robust dictionary can be learned even if the characteristics of the source domain and target domain are evidently different under the interference of a realistic and changeable operation environment.Such a dictionary can effectively improve the performance of process monitoring and mode classification.Extensive experiments including a numerical simulation and two industrial systems are conducted to verify the efficiency and superiority of the proposed method.
文摘Objective.To understand and analyze the mental health status of key Senior School Students at grade 3 in Haidian District of Bey ing and Senior Three Students in General Schools,so as to provide basis for mental health education and psychological intervention.Methods.A total of 263 senior three students were randomly selected from a general school and two key school in Haidian District of Beijing.A questionnaire survey was conducted using the Mental Health Scale for Chinese Middle School Students(MSSMHS).Results.Of the 260 students surveyed,54.2%had mental health problems,36.5%had mild problems,8.8%had moderate problems,and 0.5%had slightly and deeply serious problems.The first three factors about examined rates of factors of mental health were anxiety,learning and interpersonal relationship.The detection rates accounted for 23.5%,23.1%and 18.8%respectively.There was no significant difference in the scores of each factor between key and ordinary middle school students(P>0.05).The scores of interpersonal,depression,anxiety and emotional factors of middle school girls were higher than those of boys,with statistical significance(P<0.05)?Conclusion.There are some mental health problems among senior students at grade 3 in Haidian District of Beijing,and female students9 are serious.Schools,families and societies should pay attention to this problem and strengthen mental health education with a focused goal.
文摘Based on the perspective of psychology,this paper analyzes the causes and characteristics of college students’network mass incidents,explores the psychological factors of college students’network mass incidents,and puts forward the educational strategies to solve college students’network mass incidents:(1)Adhere to humanism and take appeals as the center;(2)To improve the campus network public opinion guidance mechanism under the guidance of relevant social cognition theories;(3)Strengthen communication and improve communication skills;(4)Promote information disclosure and transparency,and eliminate uncertainty and ambiguity.
基金supported by the National Natural Science Foundation of China(21905198)the Starting Grants of Tianjin University,Tianjin Government.
文摘Highly efficient persistent organic room temperature phosphorescence(RTP) has attracted increasing attention because of promising applications in fields of chemical sensors, optoelectronic devices, information security, and bioimaging, etc. Wherein,the crystal engineering of H-aggregation offers stabilization for long-lived triplet exciton for RTP, but the related research is rare because of the scarcity of ideal phosphorescent H-aggregate. Herein, we designed planar tricoordinate organoboron derivatives with molecular arrangement in ideal H-aggregation. The integration of Br atom can largely enhance RTP efficiency through increasing SOC effect, while the antiparallel molecular arrangement causes annihilation of triplet exciton. Thanks to good selfassembly property, their RTP can even be observed in PMMA matrix with doping ratio of merely 1 wt%. We further found that the cryogenic temperature contributes to stabilizing triplet exciton in H-aggregation, leading to red-shifted phosphorescence. By applying high hydrostatic pressure, the phosphorescence was largely enhanced and redshifted, demonstrating the crucial role of H-aggregation on RTP property. In phosphorescent tissue imaging of live mouse, nanoparticles of BrBA exhibited high contrast image via eliminating the interference of autofluorescence.
文摘Based on the perspective of psychology,this paper analyzes the causes and characteristics of college students’network mass incidents,explores the psychological factors of college students’network mass incidents,and puts forward the educational strategies to solve college students’network mass incidents:No.1.Adhere to humanism and take appeals as the center;No.2.To improve the campus network public opinion guidance mechanism under the guidance of relevant social cognition theories;No.3.Strengthen communication and improve communication skills;No.4.Promote information disclosure and transparency,and eliminate uncertainty and ambiguity.
基金supported by the National Natural Science Foundation of China(82370019)the Emergency Key Program of Guangzhou Laboratory(EKPG21-30-4)+1 种基金the National Key Research and Development Plan(2022YFC2304404,2022YFC2304803)the Military Emergency Research Project on COVID-19(BWS20J006).
文摘China.In this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing region.Methods:In this retrospective study,we enrolled inpatients admitted for COVID-19 in the Fifth Medical Center of Chinese PLA General Hospital in Beijing between November 10,2022,and January 30,2023.Demographic and clinical features and treatment outcomeswere comprehensively analyzed.We used logistic regression and linear regression analyses to explore the risk factors associated with disease severity and time of nucleic acid conversion,respectively.Results:A total of 1010 hospitalized patients with COVID-19 were enrolled.The median age was 43.0 years(interquartile range,28.0–63.0),and patients aged<60 years and≥60 years comprised 71.2%and 28.8%of total included patients,respectively.The clinical classification of mild(74.6%,753/1010),moderate(21.0%,212/1010),severe(2.7%,27/1010),and unidentified(1.8%,18/1010)was separately recorded;1005 patients were discharged,and 5 patients died in the hospital.The outbreak of the emerging epidemic witnessed an evident increase in the proportion of moderate(42.9%vs.16.4%)and severe(10.3%vs.1.1%)cases after December 7,2022.Patients with a moderate/severe classification had higher levels of procalcitonin,IL-6,serum ferritin,C-reactive protein,lactic dehydrogenase,serum urea nitrogen,and D-dimer and lower counts of CD4+T,CD8+T,and B cells(all P<0.001).Multivariable regression analysis revealed that increased odds of disease severity were associated with the following factors:age≥60 years,IL-6>7 pg/mL,lactic dehydrogenase level>245 U/L,cough,and fever at admission.Age≥80 years and chronic lung diseasewere independent risk factors in the nonmild group in elderly patients.In addition,the duration for nucleic acid to turn negativewas approximately 5.0 d(interquartile range,3.0–7.0).Prolonged time of nucleic acid conversion was associated with age≥60 years,serum urea nitrogen level>8.2 mmol/L,neutrophil count>7×10^(9)/L,and the presence of a chronic lung disease or carcinoma.Finally,unvaccinated patients accounted for 37.3%of enrolled patients;children and the elder people accounted for approximately half of that.The univariable analysis found that booster doses reduced disease severity and shortened the time of nucleic acid conversion in elderly patients.Conclusions:The outbreak ofOmicron rapidly increased the number of patientswith COVID-19 in Beijing.In elderly patients,booster doses may reduce disease severity and shorten the time of nucleic acid conversion.Healthcare systems should be optimized before an emerging epidemic outbreak.
文摘Urban subways have developed rapidly in recent years and has gradually become the primary choice of public transportation in big cities.Subways can effectively alleviate urban traffic congestion and improve passengers’green travel experience,especially in the old urban areas where urban space is limited,community facilities are aging and historical features are gathered.Subways play a huge role in guiding the expansion of urban space form and improving urban landscape environment.As the only channel for passengers to get in and out of the station,the subway entrance and exit act as a bridge.It is not only the transition space between the subway station space and the urban above ground space,but also an important node for the exchange and circulation of various elements in the urban space.In this paper,the influencing factors of subway entrance and exit space environments in the old city were investigated,and relevant basis for future planning,design,and construction of subway entrances and exits were provided.Firstly,the research results and shortcomings of subway entrance and exit channels were outlined.Secondly,based on the perspective of residents and passengers,this paper uses the analytic hierarchy process to determine six first-class evaluation indexes,including safety,convenience,practicability and aesthetics.This paper constructs the evaluation system of spatial environment index of subway station entrances and exits in the old urban area of Xi’an.Lastly,according to the evaluation results,the paper puts forward the targeted optimization strategies for the current situation of the entrance and exit space environment of the subway stations in the Xi’an.
基金Acknowledgements This work was supported by the National Key Technology R&D Program (No. 2015ZX09501-004-001-008), the National TCM Industry Science and Technology Program (No. 201507004-04), the National Natural Science Foundation of China (Nos. 81373984, 81503350, and 81403126), and the Beijing Natural Science Foundation (No. 7152142). The authors wish to acknowledge Jiyan Chen for providing photographs of fraudulent Heshouwu, Yonghe Zhang for determining the pesticides, and Dongping Xu for his suggestion regarding the scale table of ECCIA.
文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。
文摘Background:Femoral interlocking intramedullary(IM)nailing fixation is an effective method for the treatment of femoral shaft fractures.Aseptic nonunion of femoral shaft fracture after IM nailing is uncommon.Currently,the treatment for aseptic femoral shaft nonunion is controversial.The aim of this study was to investigate the clinical effect of augmentative antirotational plating plus decortication and autogenic bone grafting for aseptic femoral shaft nonunion after IM nailing failure.Methods:A retrospective study was conducted on 25 cases of aseptic femoral shaft fracture nonunion treated with IM nailing from January 2015 to August 2019.All patients were treated by leaving the nail in situ,debridement of nonunionsites,decortication,autogenous iliac bone grafting,and augmentative antirotational plating fixation.The time to fracture union and complications were recorded.Results:All patients were followed up for 12–18 months.The union rate after revision surgery was 100%.The average union time was 5.5months(range,4-10).Subjective pain symptoms had disappeared in all patients.There were no incision infections or internal fixator fatigue fractures.Average scores of the physical function and bodily pain components of the SF-36 were 95.5(range,91-98)and 94.1(range,90-97),respectively.No other obvious complications occurred postoperatively.Conclusion:Augmentative antirotational plating plus decortication and autogenic bone grafting is an excellent choice for treating femoral shaft fracture nonunion after IM nailing;this approach has an overall high union rate and few complications.
基金This work was supported by The National Key R&D Program of China(Nos.2020YFC0841900,2020YFC0844000,and 2020YFC08860900)The Innovation Groups of the National Natural Science Foundation of China(No.81721002)Study on Comprehensive Treatment of Pneumonia(No.BWS20J006).
文摘The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the world according to the declaration from World Health Organization.Dysregulated immune response of both the innate and adaptive immune systems is subsistent on COVID-19 patients,of which the degree are associated with disease severity,lung damage and long term functional disability.Current treatment options have included antiretroviral drugs,anti-inflammatory factors,antibodies,immune checkpoint inhibitors,and convalescent plasma therapy.More recently,mesenchymal stem cell(MSC)therapy has been explored for the management and control of COVID-19,particularly with the aim of preventing or at least mitigating respiratory co-morbidities.Though the safety and efficacy of stem cell therapy have been validated in multiple phase I–III clinical trials,to date,no standardized stem cell preparation,administration dosage or interval,product QA/QC testing,storage,transportation,or disposal protocols have been established.The present paper proposes a systematic methodology that addresses all the foregoing process steps and evaluation criteria for the efficacious and safe administration of MSCs in the treatment of patients infected with COVID-19.
基金This studywas supported by the National Key Research and Development Program of China(No.2018YFC1002900)the National Natural Science Foundation ofChina(No.81671527),China.
文摘Congenital diaphragmatic hernia is a congenital fetal disease,which mainly causes pulmonary hypoplasia and pulmonary hypertension.Effective early prenatal diagnosis can detect and predict the prognosis of congenital diaphragmatic hernia in infants,thus provide a reference for prenatal counseling,early intervention,and potential choices for the child’s family.Ultrasound and magnetic resonance imaging are the most commonly used methods for non-invasive examination of the fetus.This paper discusses evaluation parameters based on these two imaging modalities.