Dapsone hypersensitivity syndrome(DHS)was first reported by Lowe and Smith[1]in 1949 in Nigeria and was termed“dapsone syndrome”by Allday and Barnes[2]in 1951.DHS is a drug-induced hypersensitivity syndrome(DIHS)cau...Dapsone hypersensitivity syndrome(DHS)was first reported by Lowe and Smith[1]in 1949 in Nigeria and was termed“dapsone syndrome”by Allday and Barnes[2]in 1951.DHS is a drug-induced hypersensitivity syndrome(DIHS)caused by dapsone 404’-diaminodiphenylsulfone(DDS).DHS is characterized by fever,rash,lymphadenopathy,and hepatitis,which usually develop after patients receive DDS for 5 to 6 weeks.Epidemiological studies have estimated DHS prevalence and fatality rates of 1.4%and 9.9%,respectively.[3]Until recently,the“wait and see”approach was used for patients with suspected DHS.Herein,we review recent developments in DHS research,focusing on its etiology,pathogenesis,diagnosis,and prevention,to make DDS a safer medication for most of the population through the prospective exclusion of susceptible patients before DDS administration.展开更多
Since 1981,worldwide leprosy prevalence has declined sharply due to the implementation of multidrug therapy(MDT)conducted by the World Health Organization(WHO).The national prevalence of leprosy finally decreased to 0...Since 1981,worldwide leprosy prevalence has declined sharply due to the implementation of multidrug therapy(MDT)conducted by the World Health Organization(WHO).The national prevalence of leprosy finally decreased to 0.05 per 10,000 population in 1998,which meant the WHO threshold of leprosy elimination(below 1 per 10,000 population)was reached in China through a wellorganized control network and through the implementation of MDT(1).However,the number of newly registered leprosy cases each year,the grade 2 disability(G2D)rate,as well as the rate of fatal adverse drug reactions(ADR)had not significantly changed since 1998(2–3),so leprosy is still seen as a public health problem in China.In addition,dermatological clinics rather than leprosy control stations became the main source for leprosy case finding at every level.Delayed diagnosis was common due to a general lack of awareness and adequately precise techniques among dermatologists to detect Mycobacterium leprae(M.leprae)that results in leprosy.展开更多
基金Academic promotion program of Shandong First Medical University(Nos.2019LJ002,2019RC007,2020RC001)Youth technology Innovation Support Project of Shandong Colleges and Universities(No.2019KJL003)+2 种基金National Natural Science Foundation of China(Nos.81811530342,81972946,81903224,82103734)Shandong Provincial Foreign Expert Project(No.WST2019004)China Scholarship Council(No.201806220227)
文摘Dapsone hypersensitivity syndrome(DHS)was first reported by Lowe and Smith[1]in 1949 in Nigeria and was termed“dapsone syndrome”by Allday and Barnes[2]in 1951.DHS is a drug-induced hypersensitivity syndrome(DIHS)caused by dapsone 404’-diaminodiphenylsulfone(DDS).DHS is characterized by fever,rash,lymphadenopathy,and hepatitis,which usually develop after patients receive DDS for 5 to 6 weeks.Epidemiological studies have estimated DHS prevalence and fatality rates of 1.4%and 9.9%,respectively.[3]Until recently,the“wait and see”approach was used for patients with suspected DHS.Herein,we review recent developments in DHS research,focusing on its etiology,pathogenesis,diagnosis,and prevention,to make DDS a safer medication for most of the population through the prospective exclusion of susceptible patients before DDS administration.
文摘Since 1981,worldwide leprosy prevalence has declined sharply due to the implementation of multidrug therapy(MDT)conducted by the World Health Organization(WHO).The national prevalence of leprosy finally decreased to 0.05 per 10,000 population in 1998,which meant the WHO threshold of leprosy elimination(below 1 per 10,000 population)was reached in China through a wellorganized control network and through the implementation of MDT(1).However,the number of newly registered leprosy cases each year,the grade 2 disability(G2D)rate,as well as the rate of fatal adverse drug reactions(ADR)had not significantly changed since 1998(2–3),so leprosy is still seen as a public health problem in China.In addition,dermatological clinics rather than leprosy control stations became the main source for leprosy case finding at every level.Delayed diagnosis was common due to a general lack of awareness and adequately precise techniques among dermatologists to detect Mycobacterium leprae(M.leprae)that results in leprosy.
