Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017

Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients.

Geological Characteristics and Prospecting Criteria of Senji Molybdenum Ore Body in Urad Houqi, Inner Mongolia, China

Geological Characteristics and Prospecting Indicators of Senji Molybdenum Ore Body in Urad Houqi, Inner Mongolia Based on geological mapping, soil geochemical survey, surface trough exploration and deep drilling verification and control, the Senji Molybdenum deposit was discovered. Geological characteristics of the molybdenum ore body are described. The host lithology of molybdenum ore body is mainly in the cataclastic carbonated black plagioclase gneiss of the second rock member of the Paleoproterozoic Baoyintu Group, followed by Early Carboniferous monzogranite. The genetic type of the deposit is preliminarily deduced to be a hydrothermal filling vein-type molybdenum deposit. The significance of this paper is to summarize the prospecting marks of the molybdenum ore body in this area, so as to further guide the exploration work in this area, and at the same time provide a useful reference for the exploration work of similar deposits in other areas.

Application Test of Anti-Interference Electrical Method Instrument to Urban Geophysical Prospecting in Tongzhou, Beijing

With the rapid development of the city, it is necessary to obtain geological information within 500 meters. Electrical prospecting is not only low cost and simple operation, but also solves the problem of insufficient drilling density in a survey. However, due to the dense urban buildings and strong electromagnetic interference, it is difficult for traditional electrical instruments to obtain effective data. An anti-interference electrical method instrument is designed. In the application test of Tongzhou core area in Beijing, the resistivity sounding data collected by anti-interference electrical method instrument is stable and reliable;inversion results of sounding are basically consistent with borehole data;the known Zhangjiawan fault and Yaoxinzhuang fault are obvious;basement karst collapse area inferred is basically coincident with the historical collapse area. It is proved that the anti-interference electrical method instrument is effective and can be applied to the geological survey of underground space in other cities.

Geological Characteristics and Regional Prospecting Model of Wulanchongji Gold Orebody, Alxa Youqi, Inner Mongolia, China

Five gold deposits (mineralization) were found in the study area by means of geological mapping, soil geochemical survey and trough exploration engineering. The ore-bearing lithology is mainly metamorphic feldspar sandstone of the Upper Carboniferous Benbatu Formation, and the gold (mineralization) body is controlled by both structural factors and stratigraphic factors of the Upper Carboniferous Benbatu Formation. The genetic type is preliminary concluded to be volcanic hydrothermal type, and the metallogenic age is late Variscan. In this paper, by studying the geological characteristics and metallogenic geological conditions of the gold orebody in the area, a regional prospecting model has been established, which is of great significance to better guide the prospecting work of similar gold deposits in the area and the region.

数据与连续损伤力学双驱动的增材疲劳寿命预测模型

传统的力学模型与新兴的数据驱动模型目前广泛用于增材制造的疲劳寿命预测中.其中,以连续损伤力学(Continuum Damage Mechanics, CDM)为代表的传统模型寿命预测模型存在着精度低、适用范围有限等问题,而以神经网络(Artificial Neural Network, ANN)为代表的数据驱动模型则始终受限于小样本工况.为解决上述问题,融合物理知识和数据信息的知识-数据双驱动模型近年来发展迅速.以此类双驱动模型为研究目标,本文以激光粉末床熔融成型(Laser Powder Bed Fusion, LPBF)AlSi10Mg合金为研究对象,构建了可自动标定的CDM模型,并将其与基于ANN的数据驱动模型在各种工况下进行了结合,再进一步通过特征融合、参数融合和输出融合方法的手段,构建了三类以CDM模型与ANN模型为基础的知识-数据双驱动模型,并量化分析了它们在预测精度和数据需求等方面的性能.研究结果表明:基于参数融合的模型,训练数据修正作用较为显著,在预测精度方面受CDM模型影响最小,并在CDM模型拟合结果较差时也能确保一定精度;基于特征融合的双驱动模型能最大化利用CDM模型中的物理信息,在数据充足时具有最高的预测精度与稳定性;基于输出融合的模型以CDM模型的结果为主导,利用ANN进行修正,具有五种模型中最好的非训练域(外推)预测性能.这些结果对于进一步发展知识-数据双驱动的高精度增材制造疲劳寿命预测模型具有重要的参考价值.

自制单孔通道在成人腹股沟疝腹腔镜手术中的应用评价

目的利用无菌手套及切口保护器自制单孔腹腔镜通道,进行成人腹股沟疝腹腔镜手术,并与常规三孔通道在应用价值、安全性及并发症等方面进行比较评估。方法纳入2017年7月至2019年3月中山大学附属第五医院胃肠外科行单侧或双侧完全腹膜外腹股沟疝修补术(TEP)的160例腹股沟疝患者,分为自制单孔组(SIL-TEP)及三孔组(MP-TEP),各80例,比较2组手术时间、并发症和疼痛视觉模拟量表评分(VAS)等。结果平均手术时间单孔组(86.06±33.69)min、三孔组(89.36±36.30)min,2组差异无统计学意义(P>0.05)。术后2 h VAS评分单孔组(1.89±0.84)分明显低于三孔组(2.36±1.25)分,差异有统计学意义(P=0.005);但术后24 h VAS评分[(1.55±0.50)分vs(1.63±0.48)分],差异无统计学意义(P>0.05)。术后并发症发生率单孔组23.8%、三孔组26.3%,差异无统计学意义(P>0.05)。随访6个月,单孔组无复发病例,三孔组2例疝复发。结论单孔腹腔镜TEP较三孔腹腔镜TEP的切口数量减少,术后即刻疼痛感减轻,未发生严重并发症,手术时间未明显延长。