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Effect of Milk Processed Arnebiae Radix on Body Temperature of Fever Rats
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作者 Jinwen liU Xiaohong MA +4 位作者 Huayang ZHAO liga BAI liming BAO Qishisan WU yongji li 《Medicinal Plant》 2024年第4期89-91,共3页
[Objectives]To investigate the synergistic effect of Arnebiae Radix after processing.[Methods]The effects of raw Arnebiae Radix and milk processed Arnebiae Radix on hypothermia in yeast-induced febrile rats were compa... [Objectives]To investigate the synergistic effect of Arnebiae Radix after processing.[Methods]The effects of raw Arnebiae Radix and milk processed Arnebiae Radix on hypothermia in yeast-induced febrile rats were compared.[Results]The processed and unprocessed Arnebiae Radix at high,medium and low doses all had a certain effect on inhibiting the rise of body temperature in rats.The high dose unprocessed group,the medium dose processed group and the high dose processed group had the best inhibitory effect on body temperature,the low dose processed group could delay the fever time,and the low dose unprocessed group had poor inhibitory effect on fever.[Conclusions]The prepared Arnebiae Radix has enhanced drug effect,and milk processed Arnebiae Radix can be used to replace common Arnebiae Radix to reduce the dosage of Arnebiae Radix and save Arnebiae Radix resources. 展开更多
关键词 Arnebiae Radix Fever model Body temperature
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Surface modification of PGP for a neutrophil–nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein 被引量:4
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作者 Baoyu Chen Man Luo +10 位作者 Jianming liang Chun Zhang Caifang Gao Jue Wang Jianxin Wang yongji li Desheng Xu lina liu Ning Zhang Huijun Chen Jing Qin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2018年第1期64-73,共10页
Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherap... Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherapy, tissue regeneration and inflammatory disorders, and it is known that neutrophils can accumulate in brain lesions in many brain diseases including depression. N-Acetyl Pro–Gly–Pro(PGP) peptide shows high specific binding affinity to neutrophils through the CXCR2 receptor. In this study, PGP was used to modify baicalein-loaded solid lipid nanoparticles(PGP-SLNs) to facilitate binding to neutrophils in vivo. Brain-targeted delivery to the basolateral amygdala(BLA) was demonstrated by enhanced concentration of baicalein in the BLA. An enhanced anti-depressant effect was observed in vitro and in vivo. The mechanism involved inhibition of apoptosis and a decrease in lactate dehydrogenase release. Behavioral evaluation carried out with rats demonstrated that anti-depression outcomes were achieved. The results indicate that PGP-SLNs decrease immobility time, increase swimming time and climbing time and attenuate locomotion in olfactory-bulbectomized(OB) rats. In conclusion, PGP modification is a strategy for targeting the brain with a cell–nanoparticle delivery system for depression therapy. 展开更多
关键词 PGP peptide NEUTROPHILS Dual-brain targeting delivery Solid lipid nanoparticle Depression BAICALEIN Olfactory bulbectomy rats
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Effects of external acupoint therapy using sinomenine powder against rheumatoid arthritis based on pharmacokinetic and pharmacodynamic fitting 被引量:2
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作者 Haotian Bai Rui Wang +3 位作者 Bixi Guan yongji li Yunlei Huang Jing Yang 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第21期2637-2639,共3页
To the Editor:Acupoint sticking therapy reportedly enhances the therapeutic efficacy of drugs,[1]with corresponding acupoints for the treatment of diseases,such as rheumatoid arthritis(RA)and dysmenorrhea.However,repo... To the Editor:Acupoint sticking therapy reportedly enhances the therapeutic efficacy of drugs,[1]with corresponding acupoints for the treatment of diseases,such as rheumatoid arthritis(RA)and dysmenorrhea.However,reports on the differences in the concentration and efficiency of bioactive constituents for acupoint and nonacupoint applications are lacking.The pharmacokinetics/pharmacodynamics(PK/PD)model is suitable for explaining bioactive constituents and pharmaceutical effects in vivo,and the relationship between PK and PD has been applied in traditional Chinese medicine(TCM)studies. 展开更多
关键词 medicine(TCM) ACUPOINT drugs
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