The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,...The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,a series of Beckmann rearrangement and following cascade reactions have been devel-oped herein.The protocol allows the conversion of various ketoximes into amide,thioamide,tetrazole and imide products in modular procedures.The generality and tolerance of functionalities of this method have been demonstrated.展开更多
基金supported by National Key Research and Development Project (No. 2021YFC2100100)National Natural Science Foundation of China (No. 21901123)+1 种基金Natural Science Foundation of Jiangsu Province (No. BK20190694)Jiangsu Specially Appointed Professor Plan
文摘The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,a series of Beckmann rearrangement and following cascade reactions have been devel-oped herein.The protocol allows the conversion of various ketoximes into amide,thioamide,tetrazole and imide products in modular procedures.The generality and tolerance of functionalities of this method have been demonstrated.
