The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine

The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and les- sen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hip pocampi of rats with post-stroke depression, and exert antidepressant effects.

Research Progress in the Pathogenesis of Post-stroke Depression

Post-stroke depression is an affective disorder that occurs after stroke.Its pathogenesis has not yet been fully understood,and it mainly involves neurobiology,neuroanatomy,and psychology.This paper provides an overview on the neurobiological mechanism of post-stroke depression to further understand post-stroke depression and to provide references for further research.

Clinical Research Progress on Physical Rehabilitation Therapy for Migraine

Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical efficacy of rehabilitation in the treatment of migraine and the prevention of recurrence have been widely accepted.This paper reviews the effectiveness of physical rehabilitation therapy in clinical treatment of migraine in recent years.

Effect of tonifying liver and kidney-essence herbs on expression of Nogo-A and p75^(NTR) in cerebral ischemic stroke rats model

OBJECTIVE:To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor,Nogo for neuron A(Nogo-A),and its associated signaling molecule,low-affinity neurotrophin receptor p75(p75 NTR),in rats with cerebral ischemic stroke(CIS),with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following injury to the central nervous system.METHODS:A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method.Successful model rats were divided into placebo and herb groups at random;sham-operated and control groups were set up simultaneously.Each of these groups was divided into six subgroups at random.Expression of Nogo-A and p75 NTR was evaluated with immunofluorescence microscopyatdays3,and weeks1,2,3,4and8 afteradministration.RESULTS:Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75 NTR(P<0.05 and P<0.01,respectively).CONCLUSION:Suppressing the expression of Nogo-A and p75 NTR is possibly one of the mechanisms underlying the ability of tonifying liver and kidney-essence herbs to promote recovery of the injured central nervous system.

Dental Imaging With Near-Infrared Transillumination Using Random Fiber Laser

Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion.In this paper,three light sources with different bandwidths based on a transillumination method are compared.The contrast among enamel,dentin,and caries lesion is calculated in different situations.The experimental results show that the random fiber laser has the best comprehensive quality in dental imaging due to its high spectral density,low coherence,and deep penetration.This work provides a guidance for light source selection in dental imaging.