The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and les- sen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in t...The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and les- sen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hip pocampi of rats with post-stroke depression, and exert antidepressant effects.展开更多
Post-stroke depression is an affective disorder that occurs after stroke.Its pathogenesis has not yet been fully understood,and it mainly involves neurobiology,neuroanatomy,and psychology.This paper provides an overvi...Post-stroke depression is an affective disorder that occurs after stroke.Its pathogenesis has not yet been fully understood,and it mainly involves neurobiology,neuroanatomy,and psychology.This paper provides an overview on the neurobiological mechanism of post-stroke depression to further understand post-stroke depression and to provide references for further research.展开更多
Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical e...Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical efficacy of rehabilitation in the treatment of migraine and the prevention of recurrence have been widely accepted.This paper reviews the effectiveness of physical rehabilitation therapy in clinical treatment of migraine in recent years.展开更多
OBJECTIVE:To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor,Nogo for neuron A(Nogo-A),and its associated signaling molecule,low-affinity neurotrophin rec...OBJECTIVE:To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor,Nogo for neuron A(Nogo-A),and its associated signaling molecule,low-affinity neurotrophin receptor p75(p75 NTR),in rats with cerebral ischemic stroke(CIS),with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following injury to the central nervous system.METHODS:A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method.Successful model rats were divided into placebo and herb groups at random;sham-operated and control groups were set up simultaneously.Each of these groups was divided into six subgroups at random.Expression of Nogo-A and p75 NTR was evaluated with immunofluorescence microscopyatdays3,and weeks1,2,3,4and8 afteradministration.RESULTS:Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75 NTR(P<0.05 and P<0.01,respectively).CONCLUSION:Suppressing the expression of Nogo-A and p75 NTR is possibly one of the mechanisms underlying the ability of tonifying liver and kidney-essence herbs to promote recovery of the injured central nervous system.展开更多
Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion...Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion.In this paper,three light sources with different bandwidths based on a transillumination method are compared.The contrast among enamel,dentin,and caries lesion is calculated in different situations.The experimental results show that the random fiber laser has the best comprehensive quality in dental imaging due to its high spectral density,low coherence,and deep penetration.This work provides a guidance for light source selection in dental imaging.展开更多
基金funded by the Key Science and Technology Project of Shaanxi Provincial "13115"Technology Innovation Engineering,No.2010ZDKG-65
文摘The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and les- sen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hip pocampi of rats with post-stroke depression, and exert antidepressant effects.
文摘Post-stroke depression is an affective disorder that occurs after stroke.Its pathogenesis has not yet been fully understood,and it mainly involves neurobiology,neuroanatomy,and psychology.This paper provides an overview on the neurobiological mechanism of post-stroke depression to further understand post-stroke depression and to provide references for further research.
文摘Migraine is a common and recurrent chronic disorder.Migraine is often associated with anxiety,depression and other emotional diseases.With the development of physical rehabilitation techniques,the long-term clinical efficacy of rehabilitation in the treatment of migraine and the prevention of recurrence have been widely accepted.This paper reviews the effectiveness of physical rehabilitation therapy in clinical treatment of migraine in recent years.
基金Suppored by Special Project on Traditional Chinese Medicine Science and Technology of State Administration of Traditional Chinese Medicine of the PRC(No.06-07LB21)
文摘OBJECTIVE:To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor,Nogo for neuron A(Nogo-A),and its associated signaling molecule,low-affinity neurotrophin receptor p75(p75 NTR),in rats with cerebral ischemic stroke(CIS),with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following injury to the central nervous system.METHODS:A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method.Successful model rats were divided into placebo and herb groups at random;sham-operated and control groups were set up simultaneously.Each of these groups was divided into six subgroups at random.Expression of Nogo-A and p75 NTR was evaluated with immunofluorescence microscopyatdays3,and weeks1,2,3,4and8 afteradministration.RESULTS:Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75 NTR(P<0.05 and P<0.01,respectively).CONCLUSION:Suppressing the expression of Nogo-A and p75 NTR is possibly one of the mechanisms underlying the ability of tonifying liver and kidney-essence herbs to promote recovery of the injured central nervous system.
基金supported in part by the National Natural Science Foundation of China(Grant Nos.11974071 and 61635005)in part by Sichuan Science and Technology Program(Grant No.2018HH0148)。
文摘Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries lesion.In this paper,three light sources with different bandwidths based on a transillumination method are compared.The contrast among enamel,dentin,and caries lesion is calculated in different situations.The experimental results show that the random fiber laser has the best comprehensive quality in dental imaging due to its high spectral density,low coherence,and deep penetration.This work provides a guidance for light source selection in dental imaging.