A method for fast 1-fold cross validation is proposed for the regularized extreme learning machine （RELM）. The computational time of fast l-fold cross validation increases as the fold number decreases, which is oppo...A method for fast 1-fold cross validation is proposed for the regularized extreme learning machine （RELM）. The computational time of fast l-fold cross validation increases as the fold number decreases, which is opposite to that of naive 1-fold cross validation. As opposed to naive l-fold cross validation, fast l-fold cross validation takes the advantage in terms of computational time, especially for the large fold number such as l 〉 20. To corroborate the efficacy and feasibility of fast l-fold cross validation, experiments on five benchmark regression data sets are evaluated.展开更多
The pruning algorithms for sparse least squares support vector regression machine are common methods, and easily com- prehensible, but the computational burden in the training phase is heavy due to the retraining in p...The pruning algorithms for sparse least squares support vector regression machine are common methods, and easily com- prehensible, but the computational burden in the training phase is heavy due to the retraining in performing the pruning process, which is not favorable for their applications. To this end, an im- proved scheme is proposed to accelerate sparse least squares support vector regression machine. A major advantage of this new scheme is based on the iterative methodology, which uses the previous training results instead of retraining, and its feasibility is strictly verified theoretically. Finally, experiments on bench- mark data sets corroborate a significant saving of the training time with the same number of support vectors and predictive accuracy compared with the original pruning algorithms, and this speedup scheme is also extended to classification problem.展开更多
Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of ...Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds.展开更多
In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental swit...In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway).展开更多
基金supported by the National Natural Science Foundation of China(51006052)the NUST Outstanding Scholar Supporting Program
文摘A method for fast 1-fold cross validation is proposed for the regularized extreme learning machine （RELM）. The computational time of fast l-fold cross validation increases as the fold number decreases, which is opposite to that of naive 1-fold cross validation. As opposed to naive l-fold cross validation, fast l-fold cross validation takes the advantage in terms of computational time, especially for the large fold number such as l 〉 20. To corroborate the efficacy and feasibility of fast l-fold cross validation, experiments on five benchmark regression data sets are evaluated.
基金supported by the National Natural Science Foundation of China(50576033)
文摘The pruning algorithms for sparse least squares support vector regression machine are common methods, and easily com- prehensible, but the computational burden in the training phase is heavy due to the retraining in performing the pruning process, which is not favorable for their applications. To this end, an im- proved scheme is proposed to accelerate sparse least squares support vector regression machine. A major advantage of this new scheme is based on the iterative methodology, which uses the previous training results instead of retraining, and its feasibility is strictly verified theoretically. Finally, experiments on bench- mark data sets corroborate a significant saving of the training time with the same number of support vectors and predictive accuracy compared with the original pruning algorithms, and this speedup scheme is also extended to classification problem.
基金National Key R&D Program of China (2016YFD0100303 and 2016YFD0101001)Beijing Natural Science Foundation (6172032).
文摘Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds.
基金supported by grants from National Natural Science Foundation of China(31770210 and 31570191)National Key Research and D evelopm ent Program of China(2016YFD0100303).
文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway).
