Collagen,one of the major components in the mammalian connective tissues,plays an essential role in many vital physiological processes.Many common diseases,such as fibrosis,overuse injuries,and bone fracture,are assoc...Collagen,one of the major components in the mammalian connective tissues,plays an essential role in many vital physiological processes.Many common diseases,such as fibrosis,overuse injuries,and bone fracture,are associated with collagen arrangement defects.However,the underlying mechanism of collagen arrangement defects remains elusive.In this study,we applied infrared scattering-type scanning near-field optical microscopy to study collagen fibrils’structural properties.Experimentally,we observed two types of collagen fibrils’arrangement with different periodic characteristics.A crystal sliding model was employed to explain this observation qualitatively.Our results suggest that the collagen dislocation propagates in collagen fibrils,which may shed light on many collagen diseases’pathogenesis.These findings help to understand the regulation mechanism of hierarchical biological structure.展开更多
基金supported by the National Key Research and Development Program of China(2022YFA1203500)the National Natural Science Foundation of China(11874407,11721404,61888102,12204125,12074416,and 12222414)+5 种基金the National Key Basic Research Program of China(2019YFA0308500)the Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(XDB30000000 and XDB33030200)CAS Project for Young Scientists in Basic Research(YSBR-003)the CAS Youth Interdisciplinary Teamthe Youth Innovation Promotion Association of CAS(2018008)China Postdoctoral Science Foundation(2021M703173)。
基金the National Key Research and Development Program of China(No.2016YFA0203500)the National Natural Science Foundation of China(No.11874407)Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB 30000000)。
文摘Collagen,one of the major components in the mammalian connective tissues,plays an essential role in many vital physiological processes.Many common diseases,such as fibrosis,overuse injuries,and bone fracture,are associated with collagen arrangement defects.However,the underlying mechanism of collagen arrangement defects remains elusive.In this study,we applied infrared scattering-type scanning near-field optical microscopy to study collagen fibrils’structural properties.Experimentally,we observed two types of collagen fibrils’arrangement with different periodic characteristics.A crystal sliding model was employed to explain this observation qualitatively.Our results suggest that the collagen dislocation propagates in collagen fibrils,which may shed light on many collagen diseases’pathogenesis.These findings help to understand the regulation mechanism of hierarchical biological structure.
