Numerical Simulation and Moist Potential Vorticity Analysis of Torrential Rain in Jiangxi Province during June 2010

Based on the conventional ground observational data,a numerical simulation and moist potential vorticity( MPV) analysis has been carried on heavy rainfall event over Jiangxi province from 19 June to 20 June 2010,with a meso-scale rainstorm model. The results show that this rare rainstorm is a typical heavy rainfall over Meiyu front. The cold air flow behind North China vortex joined up the southwestern flow located in the northwest part of the strong and stable subtropical high,thus the cold air and warm air converged and maintained over the northern part of Hunan and Jiangxi province. The simulated precipitation of the high resolution model is very similar to the observational rainfall. The model has a good predictive skill for the location,intensity and center of heavy rainfall. By moist potential vorticity analysis,it is found that the distribution characteristic of MPV which heavy rainfall happens ahead has an obvious indication for precipitation forecast. The vertical overlapping of the positive and negative MPV1 areas is favorable to the generation and development of rainstorm. This zone is also the conjoint area of convective instability and baroclinic instability.

中药苦参汤加减熏洗结合保留括约肌术治疗后肛周脓肿的临床疗效探讨

本研究的目的是探讨中药苦参汤加减熏洗与保留括约肌术结合治疗肛周脓肿的临床疗效。本次研究对象为湖南中医药大学第二附属医院肛肠科2023年1月至2024年1月收治的120例肛周脓肿患者。将120名肛周脓肿患者随机分配到两个治疗小组中,一组遵循传统手术治疗方案,而另一组则实施中药苦参汤加减熏洗结合保留括约肌术的治疗方式。经过对这些患者的治疗与观察,我们得出的结论是:实施中药苦参汤加减熏洗结合保留括约肌术的治疗小组在治疗效果上显著胜出,总体有效率高达96.7%。不仅如此,接受此方案的患者术后康复速度较快,疼痛程度明显减轻,且术后并发症的发生率相对较低。相较之下,接受传统手术治疗的患者术后疼痛明显,且部分患者还出现了术后感染、出血等并发症状。这项研究充分证明,采用中药苦参汤加减熏洗结合保留括约肌术对肛周脓肿的治疗,不仅效果显著,还具有良好的临床效益,因此,该方法值得在临床上得到广泛的推广与应用。

A Numerical Study of Mesoscale Vortex Formation in the Midlatitudes:The Role of Moist Processes

In this study, a three-dimensional mesoscale model was used to numerically simulate the well-known "98.7" heavy rainfall event that affected the Yangtze Valley in July 1998. Two experiments were conducted to analyze the impact of moist processes on the development of meso-β scale vortices(MβV) and their triggering by mesoscale wind perturbation(MWP). In the experiment in which the latent heat feedback(LHF) scheme was switched off, a stable low-level col field(i.e., saddle field—a region between two lows and two highs in the isobaric surface) formed, and the MWP triggered a weak MβV. However, when the LHF scheme was switched on as the MWP was introduced into the model, the MβV developed quickly and intense rainfall and a mesoscale low-level jet(mLLJ) were generated. The thickness of the air column and average temperature between 400 and 700 hPa decreased without the feedback of latent heat, whereas they increased quickly when the LHF scheme was switched on, with the air pressure falling at low levels but rising at upper levels. A schematic representation of the positive feedbacks among the mesoscale vortex, rainfall, and mLLJ shows that in the initial stage of the MβV, the MWP triggers light rainfall and the latent heat occurs at low levels, which leads to weak convergence and ageostrophic winds. In the mature stage of the MβV, convection extends to the middle-to-upper levels, resulting in an increase in the average temperature and a stretching of the air column. A low-level cyclonic circulation forms under the effect of Coriolis torque, and the m LLJ forms to the southeast of the MβV.

2型鱼雷样黄斑病变1例

患者,女,17岁,因“右眼视物模糊”在当地医院验光诊断后行眼底检查发现右眼眼底异常2个月,建议至上级医院就诊,于2023年8月6日就诊于河南省立眼科医院。既往体健,围产期状况良好,否认眼部外伤、手术及相关眼病家族史,无长期服用药物史。眼部查体:双眼视力1.0;右眼眼压13 mmHg(1 mmHg=0.133 kPa),左眼14 mmHg。双眼眼睑组织及眼前节检查无异常。

Application of Gaussian Weight to Improve Perturbation Features of Convection-Permitting Ensemble Forecast Based on Local Breeding of Growing Modes

Local breeding of growing modes(LBGM)is a method used to generate initial condition perturbation(ICP)for convection-permitting ensemble forecasts.Equal weights(EWs)are usually presumed in LBGM during the localization of ICP,without considering different contributions of the grid points within the local radius.To address this problem,Gaussian weights(GWs)are proposed in this study,which can accommodate the varied influences of the grids inside the local radius on the central grid through a Gaussian function.Specifically,two convection-permitting ensemble forecast experiments based on LBGM with GWs and EWs are compared and analyzed respectively for two squall line cases.The results showed that the use of the GWs intensified the local characteristics of the ICP and made the distribution of the ICP fields more flow-dependent.Kinetic energy spectrum of the ICP indicated that there could be more large-scale information in the ICP by using the GWs.In addition,mesoscale information also improved slightly.For forecast of nonprecipitation variables,GWs improved the relationship between the root-mean-square error and the spread and contributed to the forecasting accuracy of wind,temperature,geopotential height,and humidity.For the precipitation forecast,GWs simulated the precipitation structure successfully and provided better probability forecasting during the evolution of the two squall line processes than the EWs.

FAM89A and IFI44L for distinguishing between viral and bacterial infections in children with febrile illness

Importance: The current lack of reliable rapid tests for distinguishing between bacterial and viral infections has contributed to antibiotic misuse.Objective: This study aimed to develop a novel biomarker assay that integratesFAM89A andIFI44L measurements to assist in differentiating between bacterial and viral infections.Methods: This prospective study recruited children with febrile illness from two hospitals between July 1, 2018, and June 30, 2019. A panel of three experienced pediatricians performed reference standard diagnoses of all patients (i.e., bacterial or viral infection) using available clinical and laboratory data, including a 28-day follow-up assessment. Assay operators were blinded to the reference standard diagnoses. The expression levels ofFAM89A andIFI44L were determined by quantitative real-time polymerase chain reaction assessment.Results: Of 133 potentially eligible patients with suspected bacterial or viral infection, 35 were excluded after the application of exclusion criteria. The resulting cohort included 98 patients: 59 with viral diagnoses and 39 with bacterial diagnoses. The areas under the curve (AUCs) of diagnoses usingFAM89A andIFI44L were 0.694 [95% confidence interval (CI): 0.583-0.804] and 0.751 (95%CI: 0.651-0.851), respectively. The disease risk score (DRS) [log2(FAM89A expression) - log2(IFI44L expression)] signature achieved an improved area under the receiver operating characteristic curve (AUC, 0.825;95%CI: 0.735-0.915), compared with the AUC generated from individual host RNA. A combination of the DRS and the C-reactive protein (CRP) level achieved an AUC of 0.896 (95%CI: 0.825-0.966). Optimal cutoffs for the DRS and CRP level were -3.18 and 19.80 mg/L, respectively.Interpretation: The DRS was significantly more accurate than the CRP level in distinguishing between bacterial and viral infections;the combination of these two parameters exhibited greater sensitivity and specificity. This study provides information that could be useful for the clinical application ofFAM89A andIFI44L in terms of distinguishing between viral and bacterial infections.