In a recent study published in Cell Metabolism,Wenes et al.1identifed that the inhibition of mitochondrial pyruvate carrier(MPC)led to CD8^(+) memory T cell(T_(mem))differentiation and facilitated superior and long-la...In a recent study published in Cell Metabolism,Wenes et al.1identifed that the inhibition of mitochondrial pyruvate carrier(MPC)led to CD8^(+) memory T cell(T_(mem))differentiation and facilitated superior and long-lasting anti-tumor activity of chimeric antigen receptor(CAR)T cells,which suggests a potential target for enhancing anti-tumor immunity.展开更多
基金This work was supported by the Major International(Regional)Joint Research Programof theNationalNatural ScienceFoundationof China(No.81920108027)ChongqingOutstandingYouth ScienceFoundation(No.cstc2020jcyj-jqx0030)+1 种基金Chongqing Talent Innovation Leader Project(No.CQYC20200301111)Funding for Chongqing University Innovation Research Group.
文摘In a recent study published in Cell Metabolism,Wenes et al.1identifed that the inhibition of mitochondrial pyruvate carrier(MPC)led to CD8^(+) memory T cell(T_(mem))differentiation and facilitated superior and long-lasting anti-tumor activity of chimeric antigen receptor(CAR)T cells,which suggests a potential target for enhancing anti-tumor immunity.
