Intravascular photoacoustic and optical coherence tomography imaging dual-mode system for detecting spontaneous coronary artery dissection: A feasibility study

In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary artery dissection(SCAD)phantoms.IVPAI provides high-resolution and high-penetration images of intramural hematoma(IMH)at different depths,so it is especially useful for imaging deep blood clots associated with imaging phantoms.IVOCT can readily visualize the double-lumen morphology of blood vessel walls to identify intimal tears.We also demonstrate the capability of this dual-mode endoscopic system using mimicking phantoms and biological samples of blood clots in ex vivo porcine arteries.The results of the experiments indicate that the combined IVPAI and IVOCT technique has the potential to provide a more accurate SCAD assessment method for clinical applications.

昆明城市热岛效应的数值模拟研究

本文利用WRF(V3.9.1)模式中耦合Noah/SLUCM方案作为Control试验,研究了土地利用类型(Md04试验)、陆面过程(NoUCM试验)和湖泊(Nolake试验)对城市热岛强度及昆明城市气象要素水平、垂直的时空分布影响。主要结论如下:(1)四个试验城市热岛强度的平均日变化趋势相似,白天城市热岛强度较弱、夜间较强,在20时(北京时,下同)左右达到最大值。城市冠层(湖泊)对城市热岛有较明显的减(增)温,Control-NoUCM(Nolake)试验中,平均日最大差值为−0.79°C(+1.07°C)。(2)从能量平衡方程分析Control-Md04试验,感热(潜热)通量的差值为+46.18(−79.71)W m^(−2),潜热通量释放大于感热通量的绝对值。Control-NoUCM试验中,感热(潜热)通量的差值为−40.88(+29.60)W m^(−2);因NoUCM试验未考虑几何建筑物储热与遮挡,太阳辐射大部分被地表所吸收,导致感热通量偏大。(3)四种试验中,15(07)时边界层高度达到最大(小)值。NoUCM(Nolake)试验中城市边界层高度分别降低103 m(32 m)左右,而Md04试验中城市边界层高度增加102 m左右。(4)湖泊(滇池)对城市热岛环流影响的试验表明,湖泊上空垂直运动较弱,但水平方向湖陆风较大,这有利于向城市输送水汽,增加干空气湿度,使城市中空气的水汽含量增加,同时增大潜热能量释放,降低感热通量,减小了垂直温度梯度。

Host-guest interaction of β-cyclodextrin with isomeric ursolic acid and oleanolic acid:physicochemical characterization and molecular modeling study

Ursolic acid(UA) and oleanolic acid(OA) are insoluble drugs. The objective of this study was to encapsulate them into β-cyclodextrin(β-CD) and compare the solubility and intermolecular force of β-CD with the two isomeric triterpenic acids. The host-guest interaction was explored in liquid and solid state by ultraviolet-visible absorption,1H NMR, phase solubility analysis, and differential scanning calorimetry, X-ray powder diffractometry, and molecular modeling studies. Both experimental and theoretical studies revealed that β-CD formed 1: 1 water soluble inclusion complexes and the complexation process was naturally favorable. In addition, the overall results suggested that ring E with a carboxyl group of the drug was encapsulated into the hydrophobic CD nanocavity. Therefore, a clear different inclusion behavior was observed, and UA exhibited better affinity to β-CD compared with OA in various media due to little steric interference, which was beneficial to form stable inclusion complex with β-CD and increase its water solubility effectively.

A Hybrid Local/Nonlocal Continuum Mechanics Modeling and Simulation of Fracture in Brittle Materials

Classical continuum mechanics which leads to a local continuum model,encounters challenges when the discontinuity appears,while peridynamics that falls into the category of nonlocal continuum mechanics suffers from a high computational cost.A hybrid model coupling classical continuum mechanics with peridynamics can avoid both disadvantages.This paper describes the hybrid model and its adaptive coupling approach which dynamically updates the coupling domains according to crack propagations for brittle materials.Then this hybrid local/nonlocal continuum model is applied to fracture simulation.Some numerical examples like a plate with a hole,Brazilian disk,notched plate and beam,are performed for verification and validation.In addition,a peridynamic software is introduced,which was recently developed for the simulation of the hybrid local/nonlocal continuum model.

Changes of hepatic biochemical parameters and proteomics in broilers with cold-induced ascites

Ascites syndrome is still a problem for chicken industry in various parts of the world. Despite the intensive investigations of this syndrome for many years, its pathogenesis remains unclear. The objective of this study was to analyze the difference in hepatic proteomics between ascites and healthy broilers by two-dimensional electrophoresis （2-DE） and matrix-assisted laser desorption/ionization-time of flight mass spectrometry （MALDI-TOF-MS）. Changes of biochemical parameters of liver and blood were also determined. The results indicated that red blood cell counts （RBC）, hematocrit （HCT） and haemoglobin （HGB） of ascites broilers were significantly greater than healthy broilers. Hepatic malondialdehyde （MDA） level of ascites broilers was significantly increased, and the activity of total superoxide dismutase （T-SOD） was significantly decreased. Hepatic lactic acid （LD） level of ascitic broilers were significantly lower than healthy ones, Serum glucose and cholesterol level of ascites broilers were significantly increased, and serum globulin level was significantly decreased in ascites broilers. There was no significant difference in triglyceride （TG） and blood urea nitrogen （BUN） level. The activity of liver hexokinase （HK） and succinodehydrogenase （SDH） in ascites broilers was significantly decreased, and there was no significant difference in the activity of liver pyruvate kinase （PK） and Na＋-K＋-ATPase. The hepatic proteomics analysis showed that 18 proteins expression difference were identified between ascites and healthy broilers. These proteins were mainly involved in： 1） cytoskeleton; 2） glucose, lipids and amino acid metabolism; 3） cell secretion; 4） cell apoptosis; 5） signal transduction; 6） immune and inflammatory response; and 7） cellular redox homeostasis. Mitochondrial isoform phosphoenolpyruvate carboxykinase （M-PEPCK） mainly participates in gluconeogenesis of chicken liver. In conclusion, liver oxidative damage was significantly aggravated, but antioxidant capacity was decreased in cold-induced ascites broilers. Serum glucose level was significantly increased, with liver M-PEPCK expression higher in ascites broilers, which implied that some potential regulatory reagents may reduce ascites susceptibility and mortality under cold temperature by increasing liver gluconeogenesis level.

规模化养猪场非洲猪瘟防疫策略

中国人的肉食结构中猪肉占比超过八成,形成为中华民族一种特有的文化现象。2018年以来非洲猪瘟疫情导致了生猪养殖量急剧减少,为了保障猪肉产品的供给,规模化养猪场的生猪复养势在必行。文章提出了规模化生猪养殖场的全面防疫策略,包括猪场全面消毒、增强生物安全意识、争取政策补贴、坚持自繁自养和分区分级管理、规范化工作流程等防疫策略,以供同行借鉴参考。

Experiment and parameter optimization of an automatic row following system for the traction beet combine harvester

To improve the automation level and operation quality of China's beet harvester and reduce the loss due to damaged and missed excavation,this study used a self-developed sugar beet combine harvester and field simulation experiment platform,based on the single-factor bench test of the automatic row following system in the early stage,taking hydraulic flow A,spring preload B,and forward speed C which have significant influence on performance indices as test factors,and taking the missed excavation rate,breakage rate and reaction time as performance indices,the orthogonal experimental study on the parameter optimization of the three-factor and three-level automatic row following system with the first-order interaction of various factors was carried out.The results of the orthogonal experiments were analyzed using range analysis and variance analysis.The results showed that there were differences in the influence degree,factor priority order and first-order interaction,and the optimal parameter combination on each performance index.A weighted comprehensive scoring method was used to optimize and analyze each index.The optimal parameter combination of the overall operating performance of the automatic row following system was A 2B 2C 1,that is,the hydraulic flow was 25 L/min,the forward speed was 0.8 m/s,and the spring preload was 198 N.Under this combination,the response time was 0.496 s,the missed excavation rate was 2.35%,the breakage rate was 3.65%,and the operation quality was relatively good,which can meet the harvest requirements.The comprehensive optimization results were verified by field experiments with different ridge shapes and different planting patterns.The results showed that the mean values of the missed excavation rate of different planting patterns of conventional straight ridges and extremely large"S"ridges were 2.23%and 2.69%,respectively,and the maximum values were 2.39%and 2.98%,respectively;the average damage rates were 3.38%and 4.14%,and the maximum values were 3.58%and 4.48%,which meet the industry standards of sugar beet harvester operation quality.The overall adaptability of the automatic row following system is good.This study can provide a reference for research on automatic row following harvesting systems of sugar beets and other subsoil crop harvesters.

Data-driven design of Ni-based turbine disc superalloys to improve yield strength

Increasing the thrust-weight ratio of aeroengines requires development of high-strength and stable high-temperature materials. A data-driven design of Ni-based turbine disc superalloys is performed to improve the yield strength to reach the target. Through first-principles calculations determining the design superalloy system, the theoretical models and Calculation of Phase Diagram (CALPHAD) screening compositions, and machine learning extrapolating prediction, 14 compositions are selected from 2,865,039 composition combinations. Ni-17Cr-8Co-1Mo-1W-6Al-3Ti-1Nb-1Ta is selected to verify the design accuracy. Experimental tests prove that the designed alloy has trade-offs of microstructure with satisfying design targets, and then, the yield strength is higher in the designed alloy than in commercial superalloys, reaching 728 MPa at 850 ℃. A scheme for increasing the performance of the designed alloy is proposed by discussing the strengthening mechanisms, machine learning process, and alloying chemistry effect. The cross-scale data-driven design is regarded as an accurate and efficient way to design novel high-strength Ni-based turbine disc superalloys, whose significance is the obvious reduction of trial-and-error tests.

Design and modelling of the full-feed peanut picking device with selfadaptive adjustable working clearance and feeding rate

To improve the declining performance of a full-feed peanut picking device or solve the mechanical failures that occur due to fluctuations in the feeding rate during operation,the 4HLJI-3000 peanut intelligent picking combine harvester,which is a picking device with a self-adaptive adjustment of the working clearance,was developed as the research object in this study.Moreover,the key components,such as the picking roller,concave plate sieve and clearance adjustment mechanism of the concave plate sieve,were designed and analysed.Through the force analysis of the concave plate sieve of the picking device,the mathematical model of the concave plate sieve displacement of the picking device and feeding rate was obtained.The software system for monitoring,storing and analysing the concave plate sieve displacement of the picking device based on EasyBuilder Pro was designed,and the road monitoring test of displacement variation of concave plate sieve of the picking device and feeding rate was carried out.The linear function,power function,exponential function,quadratic function,compound function,logarithmic function and cubic function fitting were used to perform regression analysis of the test results by using IBM SPSS software.The results showed that the cubic function model had a higher fitting precision,and its determination coefficient was 0.992.Model verification experiments were proposed,and the results showed that the established cubic function model had a good accuracy.The absolute deviation rate ranged from 0 to 4.83%,and the average deviation rate was 2.22%.The deviation rate increased with an increasing feeding rate.The field experiments also proved that there was a cubic function relationship between the feeding rate and concave plate sieve displacement,the measured concave plate sieve displacement deviation rate ranged from 0 to 6.19%,and the average deviation rate was 2.73%compared with the calculated results.This study can provide a reference for the optimization design of the structure of full-feeding picking devices for peanuts and other crops and the intelligent measurement and control of the feeding rates.

Ultrathin lanthanide oxides nanomaterials： synthesis, properties and applications

Over the past decade, ultrathin lanthanide oxides(Ln_2O_3, Ln = La to Lu) nanomaterials have been intensively studied in the fields of rare earth materials science. This unique class of nanomaterials has shown many unprecedented properties(big surface area, high surface effect, physical and chemical activities) and is thus being explored for numerous promising applications. In this review, a brief introduction of ultrathin Ln_2O_3 nanomaterials was given and their unique advantages were highlighted. Then, the typical synthetic methodologies were summarized and compared(thermal decomposition, solvothermal, soft template, co-precipition and microwave etc.). Due to the high surface effect, some promising applications of ultrathin Ln_2O_3 nanomaterials, such as drug delivery and catalysis of CO oxidation, were reviewed. Finally, on the basis of current achievements on ultrathin Ln_2O_3 nanomaterials, personal perspectives and challenges on future research directions were proposed.

Numerical study of collection efficiency and heat-transfer characteristics of packed granular filter

The collection mechanism and heat-transfer characteristics of a packed granular filter were investigated using a three-dimensional randomly packed granular filter model. The bridging method was introduced to optimize the grids of contact points between granules. The influences of granular bed depth, gas velocity, and gas temperature on grade collection efficiency were investigated. The results indicated that a decrease of temperature improved collection efficiency when the particle diameter was greater than 5 |xm. The grade collection efficiency maintained a stable value when the Stokes number, St, was less than 0.009, but increased linearly with ig(St) when St > 0.009. A logarithmic mean temperature difference method was used to obtain overall heat-transfer coefficients of gas-solid two-phase flow through the packed granular filter. The results showed that convective heat transfer was enhanced due to the intro-duction of solid particles in the bed. The overall heat-transfer coefficient increased approximately linearly with an increase in particle loading ratio. The Nusselt number was related to the Reynolds number, the Archimedes number, and the particle loading ratio.

Diurnal and Seasonal Variations of Thermal Stratification and Vertical Mixing in a Shallow Fresh Water Lake

Among several influential factors, the geographical position and depth of a lake determine its thermal structure. In temperate zones, shallow lakes show significant differences in thermal stratification compared to deep lakes. Here,the variation in thermal stratification in Lake Taihu, a shallow fresh water lake, is studied systematically. Lake Taihu is a warm polymictic lake whose thermal stratification varies in short cycles of one day to a few days. The thermal stratification in Lake Taihu has shallow depths in the upper region and a large amplitude in the temperature gradient,the maximum of which exceeds 5°C m–1. The water temperature in the entire layer changes in a relatively consistent manner. Therefore, compared to a deep lake at similar latitude, the thermal stratification in Lake Taihu exhibits small seasonal differences, but the wide variation in the short term becomes important. Shallow polymictic lakes share the characteristic of diurnal mixing. Prominent differences on the duration and frequency of long-lasting thermal stratification are found in these lakes, which may result from the differences of local climate, lake depth, and fetch. A prominent response of thermal stratification to weather conditions is found, being controlled by the stratifying effect of solar radiation and the mixing effect of wind disturbance. Other than the diurnal stratification and convection, the representative responses of thermal stratification to these two factors with contrary effects are also discussed. When solar radiation increases, stronger wind is required to prevent the lake from becoming stratified. A daily average wind speed greater than 6 m s–1 can maintain the mixed state in Lake Taihu. Moreover, wind-induced convection is detected during thermal stratification. Due to lack of solar radiation, convection occurs more easily in nighttime than in daytime. Convection occurs frequently in fall and winter, whereas long-lasting and stable stratification causes less convection in summer.

Effect of Using Land Use Data with Building Characteristics on Urban Weather Simulations:A High Temperature Event in Shanghai

Land use data with building characteristics are important for modeling the impacts of urban morphology on local climate.In this study,an extreme heat event in Shanghai,China,was simulated by using a WRF/BEP+BEM(Weather Research and Forecasting/Building Effect Parameterization+Building Energy Model)model.We incorporated local climate zone(LCZ)land use data that resolved urban morphology using 10 classes of building parameters.The simulation was compared to a control case based on MODIS(Moderate-resolution Imaging Spectroradiometer)land use data.The findings are as follows:(1)the LCZ data performed better than the MODIS data for simulating 10-m wind speed.An increase in building height led to the wind speed to decrease by 0.6-1.4 m s^(-1)in the daytime and by 0.2-0.7 m s^(-1)at nighttime.(2)High-rise buildings warmed the air by trapping radiation in the urban canyon.This warming effect was partially offset by the cooling effect of building shadows in the day.As a result,the 2-m temperature increased by 0.8℃ at night but only by 0.4℃ during the day.(3)Heterogeneous urban surfaces increased the 50-m turbulent kinetic energy by 0.4 m^(2) s^(-2),decreased the 10-m wind speed by 1.8 m s^(-1)in the daytime,increased the surface net radiation by 45.1 W m^(2)-,and increased the 2-m temperature by 1.5℃ at nighttime.(4)The LCZ data modified the atmospheric circulation between land and ocean.The shadowing effect reduced the air temperature differences between land and ocean and weakened the sea breeze.Moreover,high-rise buildings obstructed sea breezes,restricting their impact to a smaller portion(10 km along the wind direction)of inland areas compared to that with MODIS.

Design and application of the dynamic detection platform for testing the micromechanical properties of agricultural products

The micromechanical properties of agricultural products can be used to formulate simulation models and optimize processing parameters for harvest,packaging,and storage.In this study,a detection platform was designed for conducting mechanical tests on different specimens at the tissue level.The system provided controllable and precise displacements;the relative error was less than±1.0%.The displacement and force measurements were calibrated.Micromechanical tests of apple parenchyma tissues were conducted to evaluate the performance of the proposed platform.The stress-strain curves of the specimens and the micrographs of the microstructures can be obtained simultaneously during the tests.The proposed platform has the capability to test mechanical properties and obtain micro behaviors of agricultural products at the tissue level,which helps in studying the failure mechanism of agricultural products under external loading.