Idose-type glycosides have numerous biological activities and have been widely used as anticoagulant drugs and anti-infection drugs.Thioglycosides have enhanced stability for acid-mediated or enzymatic hydrolysis,and ...Idose-type glycosides have numerous biological activities and have been widely used as anticoagulant drugs and anti-infection drugs.Thioglycosides have enhanced stability for acid-mediated or enzymatic hydrolysis,and have a wide range of applications in glycobiology and drug development.Herein,we describe an efficient method for site-selective and stereoselective synthesis of potential bioactive 2-amino-2-deoxy-1,3-dithioidoglycosides via organocatalysis sequential C3-Ferrier rearrangement and Michael addition of 3-O-acetyl-2-nitrogalactals.Both stepwise and one-pot protocols were carried out and work well.This unique thio-glycosylation protocol highlighted the various advantages,including(i)mild reaction conditions;(ii)excellent site-selectivity and stereoselectivity,good to excellent yields;(iii)broad substrate scopes;(iv)being atom-economic and environmentally friendly;(v)the reactions can be scaled up.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(21977039,22007039,22167015)the Science and Technology Department of Jiangxi Province(jxsq2020101084,20212ACB213005)Jiangxi Normal University Innovation Fund(YJS2021010).
文摘Idose-type glycosides have numerous biological activities and have been widely used as anticoagulant drugs and anti-infection drugs.Thioglycosides have enhanced stability for acid-mediated or enzymatic hydrolysis,and have a wide range of applications in glycobiology and drug development.Herein,we describe an efficient method for site-selective and stereoselective synthesis of potential bioactive 2-amino-2-deoxy-1,3-dithioidoglycosides via organocatalysis sequential C3-Ferrier rearrangement and Michael addition of 3-O-acetyl-2-nitrogalactals.Both stepwise and one-pot protocols were carried out and work well.This unique thio-glycosylation protocol highlighted the various advantages,including(i)mild reaction conditions;(ii)excellent site-selectivity and stereoselectivity,good to excellent yields;(iii)broad substrate scopes;(iv)being atom-economic and environmentally friendly;(v)the reactions can be scaled up.
