AIM To examine the effect of Helicobacter pylori(H.pylori)eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine.METHODSMedical record...AIM To examine the effect of Helicobacter pylori(H.pylori)eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine.METHODSMedical records(1 May 2013-31 January 2014)of 130patients who underwent H.pylori eradication therapy with 2-year after-eradication observation in our institute were reviewed.Data on sex;age;body weight;body mass index(BMI);mean corpuscular volume(MCV);total protein;low-density lipoprotein cholesterol,triglyceride,haemoglobin A1c and haemoglobin levels and gastric hyperplastic polyps(GHPs)at eradication was extracted.Two-year after-eradication change in data was analysed by paired-sample t-test;relationship between GHPs and subclinical iron deficiency anaemia(IDA)improvement was evaluated.RESULTSThe mean patient age(median,interquartile range)at eradication was 69.6(71.5,64-77)years.Paired-sample t-tests showed that body weight,BMI and MCV increased by 0.52 kg(P=0.018),0.25 kg/m^2(P=0.006)and 0.83f L(P<0.001),respectively.The nonparametric MannWhitney test showed no significant difference in the change rate of MCV after eradication between the groups with and without GHPs(P=0.892).CONCLUSIONH.pylori eradication therapy prevented weight loss and subclinical IDA in elderly individuals.GHPs were not associated with subclinical IDA.展开更多
文摘AIM To examine the effect of Helicobacter pylori(H.pylori)eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine.METHODSMedical records(1 May 2013-31 January 2014)of 130patients who underwent H.pylori eradication therapy with 2-year after-eradication observation in our institute were reviewed.Data on sex;age;body weight;body mass index(BMI);mean corpuscular volume(MCV);total protein;low-density lipoprotein cholesterol,triglyceride,haemoglobin A1c and haemoglobin levels and gastric hyperplastic polyps(GHPs)at eradication was extracted.Two-year after-eradication change in data was analysed by paired-sample t-test;relationship between GHPs and subclinical iron deficiency anaemia(IDA)improvement was evaluated.RESULTSThe mean patient age(median,interquartile range)at eradication was 69.6(71.5,64-77)years.Paired-sample t-tests showed that body weight,BMI and MCV increased by 0.52 kg(P=0.018),0.25 kg/m^2(P=0.006)and 0.83f L(P<0.001),respectively.The nonparametric MannWhitney test showed no significant difference in the change rate of MCV after eradication between the groups with and without GHPs(P=0.892).CONCLUSIONH.pylori eradication therapy prevented weight loss and subclinical IDA in elderly individuals.GHPs were not associated with subclinical IDA.
