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Epstein–Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature 被引量:3
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作者 Kazuya Miyaguchi Minoru Yamaoka +7 位作者 Yoshikazu Tsuzuki Keigo Ashitani Hideki Ohgo yoshitaka miyagawa Keisuke Ishizawa Hidekazu Kayano Hidetomo Nakamoto Hiroyuki Imaeda 《World Journal of Clinical Cases》 SCIE 2018年第14期776-780,共5页
A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years at our hospit... A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years at our hospital. The patient experienced high-grade fevers, chills, and cough fve d prior to presenting to the outpatient unit. At frst, the patient was suspected to have developed neutropenic fever; however, she was diagnosed with Epstein-Barr virus-associated hemophagocytic syndr-ome (EB-VAHS) upon fulfilling the diagnostic criteria after bone marrow aspiration. When patients withinflammatory bowel disease treated with immunomo-dulators, such as thiopurine preparations, develop fever, EB-VAHS should be considered in the differential diagnosis. 展开更多
关键词 Infammatory bowel disease AZATHIOPRINE Virus-associated hemophagocytic syndrome Ulcerative colitis Case report
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Coexpression of Escherichia coli RNase III in silkworm cells improves the efficiency of RNA interference induced by long hairpin dsRNAs 被引量:2
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作者 Jae Man Lee Yoshito Kojin +3 位作者 Tsuneyuki Tatsuke Hiroaki Mon yoshitaka miyagawa Takahiro Kusakabe 《Insect Science》 SCIE CAS CSCD 2013年第1期69-77,共9页
Long hairpin dsRNA transcribed from chromosomal DNA can induce RNA interference in Bombyx mori cells, although its gene silencing efficiency is lower than that of exogenously introduced double-stranded RNAs (dsRNAs)... Long hairpin dsRNA transcribed from chromosomal DNA can induce RNA interference in Bombyx mori cells, although its gene silencing efficiency is lower than that of exogenously introduced double-stranded RNAs (dsRNAs). To solve this problem, we monitored the nuclear cytoplasmic translocation of the transcribed hairpin dsRNA and analyzed the processing efficiency into mature small interfering RNA (siRNA). Northem blot analysis revealed that the transcribed hairpin dsRNAs were spliced and transported into the cytoplasm, but were not effectively diced into siRNAs. Interestingly, RNAi with hairpin dsRNAs from genome-integrated IR transgene was stimulated by the coexpression of Escherichia coli RNase III, although this exogenous enzyme seemed to bring about nonspecific cleavage of cellular mRNA. 展开更多
关键词 Bombyx mori DSRNA RNA interference RNase III siRNA
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