Worldwide, cancer and diabetes are two major chronic diseases that have great impacts on human health. Clinical and basic research studies have shown that diabetes, especially type 2 diabetes mellitus (T2DM), can prom...Worldwide, cancer and diabetes are two major chronic diseases that have great impacts on human health. Clinical and basic research studies have shown that diabetes, especially type 2 diabetes mellitus (T2DM), can promote the incidence and development of colon, pancreatic, breast, liver and bladder cancers. Hyperglycemia, chronic inflammation and abnormal metabolism are considered to be major risk factors involved in the development of cancer. Notably, some treatments used for diabetes, such as maintenance of a healthy diet and the use of hypoglycemic drugs to control blood glucose levels, may decrease the risk of cancer. On the other hand, metabolic disorders and the organ damage caused by cancer can also promote or accelerate the progression of diabetes. By reviewing the relevant literature, we found that diabetes can promote the occurrence and development of some cancers, and cancer can, in turn, influence diabetes. We herein discuss and summarize the mechanisms underlying the relationship between diabetes and cancer and the new therapeutic strategies based on this relationship.展开更多
基金grants from the NationalNatural Science Foundation of China grant (81672275,81874052, 3A214DJ63428)the Ministry of Science and Technology Project of Prevention and Control of Major Chronic Noncommunicable Diseases(2016YFC1303804).
文摘Worldwide, cancer and diabetes are two major chronic diseases that have great impacts on human health. Clinical and basic research studies have shown that diabetes, especially type 2 diabetes mellitus (T2DM), can promote the incidence and development of colon, pancreatic, breast, liver and bladder cancers. Hyperglycemia, chronic inflammation and abnormal metabolism are considered to be major risk factors involved in the development of cancer. Notably, some treatments used for diabetes, such as maintenance of a healthy diet and the use of hypoglycemic drugs to control blood glucose levels, may decrease the risk of cancer. On the other hand, metabolic disorders and the organ damage caused by cancer can also promote or accelerate the progression of diabetes. By reviewing the relevant literature, we found that diabetes can promote the occurrence and development of some cancers, and cancer can, in turn, influence diabetes. We herein discuss and summarize the mechanisms underlying the relationship between diabetes and cancer and the new therapeutic strategies based on this relationship.
