In the original publication of the article,the affiliation“College of Earth and Planetary Sciences,University of Chinese Academy of Sciences,Beijing,People’s Republic of China”for author Ziqi Wang was missing and i...In the original publication of the article,the affiliation“College of Earth and Planetary Sciences,University of Chinese Academy of Sciences,Beijing,People’s Republic of China”for author Ziqi Wang was missing and included in this correction article.展开更多
Wuyi Mountain,located in the north of Fujian Province,China,is renowned for its abundant medicinal plant resources.In July 2014,the 8th(second team)of Shenyang Pharmaceutical University’s Chinese Medicine Resources S...Wuyi Mountain,located in the north of Fujian Province,China,is renowned for its abundant medicinal plant resources.In July 2014,the 8th(second team)of Shenyang Pharmaceutical University’s Chinese Medicine Resources Scientific Expedition Team conducted field investigation in the area.Through specimen collection and extensive literature review,the team identified and analyzed 223 vascular plant species from 175 genera and 85 families.The most dominant families were Compositae and Rosaceae,and perennial herbs were the predominant species,accounting for 44.39%of the total species identified.Notably,we documented five precious and rare medicinal plants unique to Wuyi Mountain.This study updates the database of plant resources and diversity in the region,providing a valuable reference for future studies.Finally,we put forward some suggestions to enhance the conservation and sustainable utilization of Wuyi Mountain’s plant resources.展开更多
Porous carbon-based materials are promised to be lightweight dielectric microwave absorbents.Deeply understanding the influence of graphitization grade and porous structure on the dielectric parameters is urgently req...Porous carbon-based materials are promised to be lightweight dielectric microwave absorbents.Deeply understanding the influence of graphitization grade and porous structure on the dielectric parameters is urgently required.Herein,utilizing the low boiling point of Zn,porous N-doped carbon was fabricated by carbonization of ZIF-8(Zn)at different temperature,and the microwave absorption performance was investigated.The porous N-doped carbon inherits the high porosity of ZIF-8 precursor.By increasing the carbonization temperature,the contents of Zn and N elements are decreased;the graphitization degree is improved;however,the specific surface area and porosity are increased first and then decreased.When the carbonization temperature is 1000°C,the porous N-doped carbon behaves enhanced microwave absorption.With an ultrathin thickness of 1.29 mm,the ideal RL reaches-50.57 dB at 16.95 GHz and the effective absorption bandwidth is 4.17 GHz.The mechanism of boosted microwave absorption is ascribed to the competition of graphitization and porosity as well as N dopants,resulting in high dielectric loss capacity and good impedance matching.The porous structure can prolong the pathways and raise the contact opportunity between microwaves and porous carbon,causing multiple scattering,interface polarization,and improved impedance matching.Besides,the N dopants can induce electron polarization and defect polarization.These results give a new insight to construct lightweight carbon-based microwave absorbents by regulating the graphitization and porosity.展开更多
Objective: IL-22-producing CD4+ T helper cells(Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathog...Objective: IL-22-producing CD4+ T helper cells(Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathogenesis of hepatocellular carcinoma(HCC). The study aimed to determine the biological function of Th22 cells and its effector IL-22 in HCC patients.Methods: Forty-five HCC patients and 19 healthy controls were recruited and their peripheral blood was collected. The fresh HCC tissues, adjacent HCC tissues and ten normal liver tissues were also collected. Flow cytometry analysis was used to determine the frequencies of circulating Th22 cells and Th17 cells. Serum IL-22 levels were tested by enzyme-linked immunosorbent assay(ELISA). Immunohistochemical staining and real-time polymerase chain reaction(PCR) were used to detect IL-22 protein and mRNA in tissues specimens, respectively.Results: Circulating Th22 cells, Th17 cells and serum IL-22 levels were significantly elevated in HCC patients compared with those of healthy controls(P<0.001). Th22 cells were showed to be positively correlated with IL-22 in HCC patients(P<0.05), but not in healthy controls. No significant differences were found in HCC patients with HBeAg positivity or negativity in term of Th22 cells and serum IL-22 levels. The expression of IL-22 protein and mRNA was highest in HCC tissues, followed by adjacent HCC tissues and normal liver tissues. Furthermore, Th22 cells, serum IL-22 levels and IL-22 mRNA were elevated at stage III-IV compared with stage I-II of HCC(P<0.05).Conclusions: Elevation of circulating Th22 cells and IL-22 may be implicated in the pathogenesis of HCC, and potentially be cellular targets for therapeutic intervention.展开更多
AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,E...AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,Embase and Cochrane library before August 2013.The associations under allele contrast model,codominant model,dominant model,and recessive model were analyzed.The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios(OR)with 95%confidence interval(CI).Fixed effects model was used to pool the result if the test of heterogeneity was not significant,otherwise the random-effect model was selected.RESULTS:Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870(-1082 A/G),rs1800871(-819C/T),and rs1800872(-592A/C)of the IL-10 gene,which involved 928 cases and 1363 controls,were eligible for our analysis.The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS(GG+GA vs AA:OR=0.80,95%CI:0.66-0.96),(AA+GA vs GG:OR=0.68,95%CI:0.52-0.90).Subgroup analysis revealed such association only existed in Caucasian ethnicity(AA+GA vs GG,OR=0.70,95%CI:0.55-0.89).The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity(CC vs GG:OR=1.29,95%CI:1.01-1.16).There were no associations between rs1800871 polymorphisms and the IBS risk.CONCLUSION:The results suggest that IL-10 rs1800870confers susceptibility to the risk of IBS in Caucasian ethnicity,and the rs1800872 may associate with IBS risk in Asians.However,no significant associations are found between rs1800871 and IBS risk.展开更多
In this article,we briefly review the recent progress on collective flow and hydrodynamics in large and small systems at the Large Hadron Collider(LHC),which includes the following topics:extracting the QGP viscosity ...In this article,we briefly review the recent progress on collective flow and hydrodynamics in large and small systems at the Large Hadron Collider(LHC),which includes the following topics:extracting the QGP viscosity from the flow data,initial-state fluctuations and final-state correlations at 2.76 A TeV Pb-Pb collisions,correlations,and collective flow in high-energy p-Pb and p-p collisions.展开更多
BACKGROUND:Coronary microembolization(CME) is a serious complication following percutaneous coronary intervention(PCI) in patients with acute coronary syndromes.The use of metoprolol before PCI can significantly prote...BACKGROUND:Coronary microembolization(CME) is a serious complication following percutaneous coronary intervention(PCI) in patients with acute coronary syndromes.The use of metoprolol before PCI can significantly protect ischemic myocardium from myocardial damage,but the function of metoprolol in the treatment of CME is not entirely clear.This study was to explore the effect and significance of metoprolol on myocardial apoptosis and caspase-3 activation after CME in rats.METHODS:Thirty rats were randomly divided into three groups including sham-operation(control group),CME plus saline(CME group),CME plus metoprolol(metoprolol group),10 rats for each group.The CME group was induced by injecting 3 000 polyethylene microspheres(42 urn)into the left ventricle during a 10-second occlusion of the ascending aorta;the control group was injected with physiological saline instead of microembolization ball;the metoprolol or saline group was given three intravenous bolus injections before CME.Echocardiography,TUNEL staining,and Western blotting were used to evaluate cardiac function,proportion of apoptotic cells and activation of caspase-3 respectively at 6 hours after operation.RESULTS:Echocardiography parameters displayed that the metoprolol group improved cardiac function significantly compared with the CME group(PO.05).The myocardial apoptotic rate of the CME group as well as the contents of activated caspase-3 increased significantly(P<0.05),both of which were ameliorated significantly by metoprolol treatment(P<0.05).CONCLUSIONS:This study demonstrates that metoprolol can protect the myocardium during CME in rats by inhibiting apoptosis and improving cardiac function.These results suggest that the inhibition of apoptosis can be a potential therapeutic strategy for the treatment of CME.展开更多
BACKGROUND Coronary microembolization(CME)is a complicated problem that commonly arises in the context of coronary angioplasty.MicroRNAs play crucial roles in cardiovascular diseases.However,the role and mechanism of ...BACKGROUND Coronary microembolization(CME)is a complicated problem that commonly arises in the context of coronary angioplasty.MicroRNAs play crucial roles in cardiovascular diseases.However,the role and mechanism of miR-181a-5p in CME-induced myocardial injury remains unclear.METHODS We established CME rat models.Cardiac function was detected by echocardiography.Haematoxylin-basic fuchsin-picric acid staining was used to measure micro-infarction size.Serum samples and cell culture supernatants were evaluated via enzyme-linked immunosorbent assay.Cellular reactive oxygen species were determined by dichloro-dihydro-fluorescein diacetate assay,and the other oxidative stress related parameters were assayed by spectrophotometry.The dual-luciferase reporter(DLR)assay and RNA pulldown were conducted to validate the association between miR-181a-5p and X-linked inhibitor of apoptosis protein(XIAP).The expression of miR-181a-5p and XIAP mRNA were determined by quantitative reverse transcription polymerase chain reaction.Proteins were evaluated via immunoblotting.The viability of the cell was evaluated via cell counting kit-8 assay.RESULTS The miR-181a-5p level was significantly increased in CME myocardial tissues.Downregulation of miR-181a-5p improved CME-induced cardiac dysfunction and alleviated myocardial oxidative stress and inflammatory injury,whereas miR-181a-5p exhibited the opposite effects.Then,the DLR assay and RNA pulldown results revealed that miR-181a-5p directly targeting on XIAP.The XIAP level was found to be remarkably decreased after CME.XIAP overexpression attenuated CME-induced myocardial oxidative stress and inflammatory injury.Finally,in vitro rescue experiments revealed that knockdown of XIAP could abolish the protective effects of miR-181a-5p knockdown on hypoxia-induced cardiomyocyte oxidative stress and inflammatory injury.CONCLUSIONS Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and inflammation through directly targeting XIAP.展开更多
The cyclonic-static micro-bubble flotation column(FCSMC) is a highly efficient mineral processing equipment. In this study, a cell-column(FCSMC) integration process was investigated for the separation of bauxite and i...The cyclonic-static micro-bubble flotation column(FCSMC) is a highly efficient mineral processing equipment. In this study, a cell-column(FCSMC) integration process was investigated for the separation of bauxite and its feasibility was analyzed on a theoretical basis. The properties of low-grade bauxite ore from Henan Province, China were analyzed. Parameters such as reagent dosage, scraping bubble time, and pressure of the circulating pump during the sorting process were investigated and optimized to improve the flotation efficiency. On the basis of these parameters, continuous separation experiments were conducted. Bauxite concentrate with an aluminum-to-silicon(A/S) mass ratio of 6.37 and a 77.63wt% recovery rate were achieved via a flow sheet consisting of "fast flotation using a flotation cell, one roughing flotation and one cleaning flotation using flotation columns". Compared with the full-flotation-cells process, the cell?column integration process resulted in an increase of the A/S ratio by 0.41 and the recovery rate by 17.58wt%. Cell?column integration separation technology represents a new approach for the separation of middle-to-low-grade bauxite ore.展开更多
Over the recent years, it has been found that microglia pseudopodia contact synapses, detect sick ones and prune them, even in adult animals. Myelinated nerves also carry out plasticity in which microglia remove myeli...Over the recent years, it has been found that microglia pseudopodia contact synapses, detect sick ones and prune them, even in adult animals. Myelinated nerves also carry out plasticity in which microglia remove myelin debris by phagocytosis. However, it remains unknown whether microglia explore structures on nerve fibers, such as Ranvier’s node(RN) or myelin sheath, before they become debris. By double or triple staining RNs or myelin sheathes and microglia in healthy rat corpus callosum, this study unveiled direct contacts of microglia pseudopodia with RNs and with para-and inter-nodal myelin sheathes, which was then verified by electron microscopic observations. Our data indicated that microglia also explore unmyelinated nerve fibers. Furthermore, we used the animals with matured white matter;therefore, microglia may be actively involved in plasticity of matured white matter tracts as it does for synapse pruning, instead of only passively phagocytize myelin debris.展开更多
The Interfacial phenomena in mold have a great impact on the smooth operation of continuous casting process and the quality of the casting product.In this paper,the wetting behavior of CaO-Al_(2)O_(3)-based mold flux ...The Interfacial phenomena in mold have a great impact on the smooth operation of continuous casting process and the quality of the casting product.In this paper,the wetting behavior of CaO-Al_(2)O_(3)-based mold flux with different BaO and MgO contents was studied.The results showed that the contact angle between molten flux and interstitial free(IF)steel substrate increased from 62.4°to 74.5°with the increase of BaO content from 3 wt%to 7 wt%,while it decreased from 62.4°to 51.3°with the increase of MgO content from 3 wt%to 7 wt%.The interfacial tension also increased from 1630.3 to 1740.8 mN/m when the BaO content increased,but it reduced from 1630.3 to 1539.7 mN/m with the addition of MgO.The changes of contact angle and interfacial tension were mainly due to the fact that the bridging oxygen(O^(0)) at the interface was broken into non-bridging oxygen(O^(-)) and free oxygen(O_(2-)) by MgO.However,more O^(-) and O_(2-) connected into O^(0) when BaO was added,since the charge compensation effect of BaO was so stronger that it offset the effect of providing O_(2-).展开更多
Ag nanoparticles were sputter-deposited on ammonium persulfate((NH_4)_2S_2O_8) powder to obtain(NH_4)_2S_2O_8-Ag powder, which was used to synthesize the HCl-doped polyaniline-Ag(HCl-PANI-Ag) composite via a polymeriz...Ag nanoparticles were sputter-deposited on ammonium persulfate((NH_4)_2S_2O_8) powder to obtain(NH_4)_2S_2O_8-Ag powder, which was used to synthesize the HCl-doped polyaniline-Ag(HCl-PANI-Ag) composite via a polymerization procedure. The Ag nanoparticles were dispersed in the HCl-PANI matrix, and their sizes mainly ranged from 3 to 6 nm. The Ag nanoparticles did not affect the structure of emeraldine salt in the composite, and they increased the ordered crystalline regions in the HCl-PANI matrix. The HCl-PANI-Ag composite had a conductivity of(6.8 ± 0.1) S/cm, which is about four times larger than that of the HCl-PANI. The charge transport mechanism in the composite is explained by the three-dimensional Mott variable-range hopping(3D-Mott-VRH).展开更多
文摘In the original publication of the article,the affiliation“College of Earth and Planetary Sciences,University of Chinese Academy of Sciences,Beijing,People’s Republic of China”for author Ziqi Wang was missing and included in this correction article.
文摘Wuyi Mountain,located in the north of Fujian Province,China,is renowned for its abundant medicinal plant resources.In July 2014,the 8th(second team)of Shenyang Pharmaceutical University’s Chinese Medicine Resources Scientific Expedition Team conducted field investigation in the area.Through specimen collection and extensive literature review,the team identified and analyzed 223 vascular plant species from 175 genera and 85 families.The most dominant families were Compositae and Rosaceae,and perennial herbs were the predominant species,accounting for 44.39%of the total species identified.Notably,we documented five precious and rare medicinal plants unique to Wuyi Mountain.This study updates the database of plant resources and diversity in the region,providing a valuable reference for future studies.Finally,we put forward some suggestions to enhance the conservation and sustainable utilization of Wuyi Mountain’s plant resources.
基金financially supported by National Natural Science Foundation of China(Nos.51572218 and 11504293)Natural Science Foundation of Shaanxi Province(No.2019JM-138)+1 种基金Natural Science Foundation from Department of Science and Technology of Shaanxi Province(Nos.2021JQ-431,2021JM-304,and 2021JQ-427)Scientific Research Program Funded by Shaanxi Provincial Education Department(No.20JK0946)。
文摘Porous carbon-based materials are promised to be lightweight dielectric microwave absorbents.Deeply understanding the influence of graphitization grade and porous structure on the dielectric parameters is urgently required.Herein,utilizing the low boiling point of Zn,porous N-doped carbon was fabricated by carbonization of ZIF-8(Zn)at different temperature,and the microwave absorption performance was investigated.The porous N-doped carbon inherits the high porosity of ZIF-8 precursor.By increasing the carbonization temperature,the contents of Zn and N elements are decreased;the graphitization degree is improved;however,the specific surface area and porosity are increased first and then decreased.When the carbonization temperature is 1000°C,the porous N-doped carbon behaves enhanced microwave absorption.With an ultrathin thickness of 1.29 mm,the ideal RL reaches-50.57 dB at 16.95 GHz and the effective absorption bandwidth is 4.17 GHz.The mechanism of boosted microwave absorption is ascribed to the competition of graphitization and porosity as well as N dopants,resulting in high dielectric loss capacity and good impedance matching.The porous structure can prolong the pathways and raise the contact opportunity between microwaves and porous carbon,causing multiple scattering,interface polarization,and improved impedance matching.Besides,the N dopants can induce electron polarization and defect polarization.These results give a new insight to construct lightweight carbon-based microwave absorbents by regulating the graphitization and porosity.
基金received financial supports from Innovation Seedling Projects of Zigong City (2017CXM02)Key R&D Program of Sichuan Province (2017GZ0391)National Key Research and Development Program (2016YFE0102600)
基金supported by research funding from the National Natural Science Foundation (No. 81260083) and National Natural Science Foundation (No. 31360221)
文摘Objective: IL-22-producing CD4+ T helper cells(Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathogenesis of hepatocellular carcinoma(HCC). The study aimed to determine the biological function of Th22 cells and its effector IL-22 in HCC patients.Methods: Forty-five HCC patients and 19 healthy controls were recruited and their peripheral blood was collected. The fresh HCC tissues, adjacent HCC tissues and ten normal liver tissues were also collected. Flow cytometry analysis was used to determine the frequencies of circulating Th22 cells and Th17 cells. Serum IL-22 levels were tested by enzyme-linked immunosorbent assay(ELISA). Immunohistochemical staining and real-time polymerase chain reaction(PCR) were used to detect IL-22 protein and mRNA in tissues specimens, respectively.Results: Circulating Th22 cells, Th17 cells and serum IL-22 levels were significantly elevated in HCC patients compared with those of healthy controls(P<0.001). Th22 cells were showed to be positively correlated with IL-22 in HCC patients(P<0.05), but not in healthy controls. No significant differences were found in HCC patients with HBeAg positivity or negativity in term of Th22 cells and serum IL-22 levels. The expression of IL-22 protein and mRNA was highest in HCC tissues, followed by adjacent HCC tissues and normal liver tissues. Furthermore, Th22 cells, serum IL-22 levels and IL-22 mRNA were elevated at stage III-IV compared with stage I-II of HCC(P<0.05).Conclusions: Elevation of circulating Th22 cells and IL-22 may be implicated in the pathogenesis of HCC, and potentially be cellular targets for therapeutic intervention.
基金Supported by National Natural Science Foundation of China,No.81260083 and No.31360221
文摘AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,Embase and Cochrane library before August 2013.The associations under allele contrast model,codominant model,dominant model,and recessive model were analyzed.The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios(OR)with 95%confidence interval(CI).Fixed effects model was used to pool the result if the test of heterogeneity was not significant,otherwise the random-effect model was selected.RESULTS:Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870(-1082 A/G),rs1800871(-819C/T),and rs1800872(-592A/C)of the IL-10 gene,which involved 928 cases and 1363 controls,were eligible for our analysis.The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS(GG+GA vs AA:OR=0.80,95%CI:0.66-0.96),(AA+GA vs GG:OR=0.68,95%CI:0.52-0.90).Subgroup analysis revealed such association only existed in Caucasian ethnicity(AA+GA vs GG,OR=0.70,95%CI:0.55-0.89).The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity(CC vs GG:OR=1.29,95%CI:1.01-1.16).There were no associations between rs1800871 polymorphisms and the IBS risk.CONCLUSION:The results suggest that IL-10 rs1800870confers susceptibility to the risk of IBS in Caucasian ethnicity,and the rs1800872 may associate with IBS risk in Asians.However,no significant associations are found between rs1800871 and IBS risk.
基金supported by the NSFC and the MOST(Nos.11435001,11675004 and 2015CB856900)the Danish Council for Independent Research,Natural Sciencesthe Danish National Research Foundation(Danmarks Grundforskningsfond)
文摘In this article,we briefly review the recent progress on collective flow and hydrodynamics in large and small systems at the Large Hadron Collider(LHC),which includes the following topics:extracting the QGP viscosity from the flow data,initial-state fluctuations and final-state correlations at 2.76 A TeV Pb-Pb collisions,correlations,and collective flow in high-energy p-Pb and p-p collisions.
基金supported by a grant from the National Natural Science Foundation of China(30760262/C030313)
文摘BACKGROUND:Coronary microembolization(CME) is a serious complication following percutaneous coronary intervention(PCI) in patients with acute coronary syndromes.The use of metoprolol before PCI can significantly protect ischemic myocardium from myocardial damage,but the function of metoprolol in the treatment of CME is not entirely clear.This study was to explore the effect and significance of metoprolol on myocardial apoptosis and caspase-3 activation after CME in rats.METHODS:Thirty rats were randomly divided into three groups including sham-operation(control group),CME plus saline(CME group),CME plus metoprolol(metoprolol group),10 rats for each group.The CME group was induced by injecting 3 000 polyethylene microspheres(42 urn)into the left ventricle during a 10-second occlusion of the ascending aorta;the control group was injected with physiological saline instead of microembolization ball;the metoprolol or saline group was given three intravenous bolus injections before CME.Echocardiography,TUNEL staining,and Western blotting were used to evaluate cardiac function,proportion of apoptotic cells and activation of caspase-3 respectively at 6 hours after operation.RESULTS:Echocardiography parameters displayed that the metoprolol group improved cardiac function significantly compared with the CME group(PO.05).The myocardial apoptotic rate of the CME group as well as the contents of activated caspase-3 increased significantly(P<0.05),both of which were ameliorated significantly by metoprolol treatment(P<0.05).CONCLUSIONS:This study demonstrates that metoprolol can protect the myocardium during CME in rats by inhibiting apoptosis and improving cardiac function.These results suggest that the inhibition of apoptosis can be a potential therapeutic strategy for the treatment of CME.
基金This study was supported by the National Natural Science Foundation of China(No.81770346)the Project for Innovative Research Team in Guangxi Natural Science Foundation(2018GXNSFGA281006).
文摘BACKGROUND Coronary microembolization(CME)is a complicated problem that commonly arises in the context of coronary angioplasty.MicroRNAs play crucial roles in cardiovascular diseases.However,the role and mechanism of miR-181a-5p in CME-induced myocardial injury remains unclear.METHODS We established CME rat models.Cardiac function was detected by echocardiography.Haematoxylin-basic fuchsin-picric acid staining was used to measure micro-infarction size.Serum samples and cell culture supernatants were evaluated via enzyme-linked immunosorbent assay.Cellular reactive oxygen species were determined by dichloro-dihydro-fluorescein diacetate assay,and the other oxidative stress related parameters were assayed by spectrophotometry.The dual-luciferase reporter(DLR)assay and RNA pulldown were conducted to validate the association between miR-181a-5p and X-linked inhibitor of apoptosis protein(XIAP).The expression of miR-181a-5p and XIAP mRNA were determined by quantitative reverse transcription polymerase chain reaction.Proteins were evaluated via immunoblotting.The viability of the cell was evaluated via cell counting kit-8 assay.RESULTS The miR-181a-5p level was significantly increased in CME myocardial tissues.Downregulation of miR-181a-5p improved CME-induced cardiac dysfunction and alleviated myocardial oxidative stress and inflammatory injury,whereas miR-181a-5p exhibited the opposite effects.Then,the DLR assay and RNA pulldown results revealed that miR-181a-5p directly targeting on XIAP.The XIAP level was found to be remarkably decreased after CME.XIAP overexpression attenuated CME-induced myocardial oxidative stress and inflammatory injury.Finally,in vitro rescue experiments revealed that knockdown of XIAP could abolish the protective effects of miR-181a-5p knockdown on hypoxia-induced cardiomyocyte oxidative stress and inflammatory injury.CONCLUSIONS Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and inflammation through directly targeting XIAP.
基金the National Natural Science Foundation of China (No. 51174205)the Program for New Century Excellent Talents in University (No. NCET-12-0962)+1 种基金the National Basic Research and Development Program of China (No. 2014CB238905)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The cyclonic-static micro-bubble flotation column(FCSMC) is a highly efficient mineral processing equipment. In this study, a cell-column(FCSMC) integration process was investigated for the separation of bauxite and its feasibility was analyzed on a theoretical basis. The properties of low-grade bauxite ore from Henan Province, China were analyzed. Parameters such as reagent dosage, scraping bubble time, and pressure of the circulating pump during the sorting process were investigated and optimized to improve the flotation efficiency. On the basis of these parameters, continuous separation experiments were conducted. Bauxite concentrate with an aluminum-to-silicon(A/S) mass ratio of 6.37 and a 77.63wt% recovery rate were achieved via a flow sheet consisting of "fast flotation using a flotation cell, one roughing flotation and one cleaning flotation using flotation columns". Compared with the full-flotation-cells process, the cell?column integration process resulted in an increase of the A/S ratio by 0.41 and the recovery rate by 17.58wt%. Cell?column integration separation technology represents a new approach for the separation of middle-to-low-grade bauxite ore.
基金supported by R01 NS063878 and P30 MH062261 (to H.X., H.S.F.)
文摘Over the recent years, it has been found that microglia pseudopodia contact synapses, detect sick ones and prune them, even in adult animals. Myelinated nerves also carry out plasticity in which microglia remove myelin debris by phagocytosis. However, it remains unknown whether microglia explore structures on nerve fibers, such as Ranvier’s node(RN) or myelin sheath, before they become debris. By double or triple staining RNs or myelin sheathes and microglia in healthy rat corpus callosum, this study unveiled direct contacts of microglia pseudopodia with RNs and with para-and inter-nodal myelin sheathes, which was then verified by electron microscopic observations. Our data indicated that microglia also explore unmyelinated nerve fibers. Furthermore, we used the animals with matured white matter;therefore, microglia may be actively involved in plasticity of matured white matter tracts as it does for synapse pruning, instead of only passively phagocytize myelin debris.
基金financially supported by the National Natural Science Foundation of China(Nos.51874363 and U1760202)the Natural Science Foundation of Hunan Province,China(No.2019JJ40345)the Hunan Scientific Technology projects,China(Nos.2018RS3022 and 2018WK2051)。
文摘The Interfacial phenomena in mold have a great impact on the smooth operation of continuous casting process and the quality of the casting product.In this paper,the wetting behavior of CaO-Al_(2)O_(3)-based mold flux with different BaO and MgO contents was studied.The results showed that the contact angle between molten flux and interstitial free(IF)steel substrate increased from 62.4°to 74.5°with the increase of BaO content from 3 wt%to 7 wt%,while it decreased from 62.4°to 51.3°with the increase of MgO content from 3 wt%to 7 wt%.The interfacial tension also increased from 1630.3 to 1740.8 mN/m when the BaO content increased,but it reduced from 1630.3 to 1539.7 mN/m with the addition of MgO.The changes of contact angle and interfacial tension were mainly due to the fact that the bridging oxygen(O^(0)) at the interface was broken into non-bridging oxygen(O^(-)) and free oxygen(O_(2-)) by MgO.However,more O^(-) and O_(2-) connected into O^(0) when BaO was added,since the charge compensation effect of BaO was so stronger that it offset the effect of providing O_(2-).
基金financially supported by the Fundamental Research Funds for the Central Universities of China (No. 8220)
文摘Ag nanoparticles were sputter-deposited on ammonium persulfate((NH_4)_2S_2O_8) powder to obtain(NH_4)_2S_2O_8-Ag powder, which was used to synthesize the HCl-doped polyaniline-Ag(HCl-PANI-Ag) composite via a polymerization procedure. The Ag nanoparticles were dispersed in the HCl-PANI matrix, and their sizes mainly ranged from 3 to 6 nm. The Ag nanoparticles did not affect the structure of emeraldine salt in the composite, and they increased the ordered crystalline regions in the HCl-PANI matrix. The HCl-PANI-Ag composite had a conductivity of(6.8 ± 0.1) S/cm, which is about four times larger than that of the HCl-PANI. The charge transport mechanism in the composite is explained by the three-dimensional Mott variable-range hopping(3D-Mott-VRH).
